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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,Overall Survival,EGFR mutants,tyrosine kinase inhibitors
- چکیده:
- چکیده انگلیسی: Background: Lung cancer (LC) is the second leading cause of cancer death in Chile, causing >3,000 deaths every
year. Epidemiological LC data in Chile is scarce and scattered. Here, we aimed to quantify the prevalence of Epidermal
Growth Factor Receptor (EGFR) gene mutations in a Chilean cancer center. These data may identify individuals that
could benefit from targeted therapies such as Tyrosine Kinase Inhibitors (TKIs). Methods: A total of 1,405 Biopsies
from 1,381 LC patients were retrospectively analyzed retrieving clinical data from EGFR mutants including age,
gender, histological type, smoking habits and type of EGFR mutation. We also analyzed overall survival (OS) rates.
Results: From all patients 21.7% had clinically relevant EGFR mutations, and a median age at diagnosis of 65 years.
Most were female (64%), classified as adenocarcinomas (94.5%), and non-smokers/light smokers (93.1%). The most
prevalent mutation was exon-19 deletions (50.6%) followed by Leucine-to Arginine 858; OS was 15 months. Clinical
follow-up information was available for 83 patients. The use of TKIs in these patients significantly improved OS.
Conclusion: The prevalence of EGFR mutations in the studied population was 21.7%, comparable to other countries
in Latin America. The most frequent EGFR mutation was exon-19 deletion, OS in this group was 15 months, and TKIs
significantly improved OS.- انتشار مقاله: 11-05-1397
- نویسندگان: Roger Gejman,Sergio Gonzalez,Matias Munoz Medel,Bruno Nervi,Cesar Sanchez,Carolina Ibáñez,Jose Peña,Jorge Madrid,Juan Briones,Patricia Perez,Marcelo Garrido,Hector Galindo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: histology,Breast Neoplasms,Ki67 antigen,mitotic index
- چکیده:
- چکیده انگلیسی:
Introduction: Breast cancer can be classified into subtypes based on immunohistochemical markers, with Ki67 expression levels being used to divide luminal BC tumors in luminal A and B subtypes; however, Ki67 is not routinely determined due to a lack of standardization. Objective: To evaluate histological grade and Eliminate: the mitotic index to determine if they can be used as an alternative method to Ki67 staining for luminal subtype definition. Methods: We evaluated estrogen receptor positive breast cancer tissue samples. Pathological analysis included determination of Ki67. A low level of Ki67 was defined as <14% positive cells. Results: We evaluated 151 breast cancer samples; 24 (15,9%) were classified as I; 74 as HG II (49%), and 53 (35,1%) as HG III. The median value for Ki67 was 13% (range: <1% - 82%) and for MI was 2 (0-12). Histological grade I tumors exhibited Ki67 values significantly lower than HG II and III tumors (Anova, Tamhane test p=0,001). A higher Ki67 value was related to a higher MI (Rho Sperman p=0,336; R2= 0,0273). ROC curve analysis determined that a MI ≥ 3 had a sensibility of 61.9% and specificity of 66.7% in predicting a high Ki67 value (≥14%) (area under the curve: 0,691; p =0,0001). A HG I tumor or HG II-III with MI ≤2, had a high probability of corresponding to a LA tumor (76,3%), as defined using Ki67 expression, while the probability of a LB subtype was higher with HG II-III and a MI ≥3 (57.4%). Global discrimination was 68.1%. Conclusions: For the LA subtype, our predictive model showed a good correlation of HG and MI with the classification based on Ki67<14%. In the LB subtype, the model showed a weak correlation; therefore Ki67 determination seems to be needed for this group of patients.- انتشار مقاله: 01-07-1396
- نویسندگان: David Oddo,Dahiana Pulgar,Nicole Elgueta,Francisco Acevedo,Dravna Razmilic,Maria Elena Navarro,Mauricio Camus,Tomas Merino,Ignacio Retamal,Alejandra Perez-Sepulveda,Alejandra Villarroel,Hector Galindo,José Peña,Cesar Sanchez
- مشاهده