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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Glioblastoma,Polymorphism,magnetic resonance spectroscopy,astrocytoma
- چکیده:
- چکیده انگلیسی: Background: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associated
with a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repair
with gliomas, as well as lifestyle habits, comorbidities, survival and response to treatment. Methods: Were studied
303 individuals distributed into: Study Group - 100 patients with gliomas, regardless of the degree of malignancy, and
Control Group - 203 individuals without clinical signs of the disease. These polymorphisms were genotyped by TaqMan®
SNP Genotyping Assay. Significance level was set at 5%. Results: Smoking, alcohol consumption, systemic arterial
hypertension (SAH) and diabetes mellitus (DM) prevailed in patients, compared to controls (P=0.0088, P=0.0001,
P=0.0001, P=0.0011, respectively). In the logistic regression analysis, alcohol consumption and SAH were identified
as independent risk factors for gliomas (P=0.0001, P=0.0027, respectively). Patients with low-grade gliomas showed
survival in one year (92.0±6.8%), compared to patients with high-grade gliomas (24.0±5.3; P=0.011). Conclusion:
Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas.
On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade
gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show
increased survival of patients.- انتشار مقاله: 20-11-1397
- نویسندگان: Maria Clara Jessica Calastri,Gabriela Hattori,Nicolas Luz Toledo Ortega Rodrigues,Michele Lima Gregorio,Camila Ive Ferreira Oliveira Brancati,Eliane Milharcix Zanovelo,José Roberto Lopes Ferraz Filho,Cassiano Merussi Neiva,Antonio Carlos Ponde Rodrigues Junior,Moacir Fernandes De Godoy,Carmen Lucia Penteado Lancellotti,Waldir Antonio Tognola,Dorotéia Rossi Silva Souza
- مشاهده