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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Teaching Language Skills
- نوع مقاله: Journal Article
- کلمات کلیدی: Genre,Generic Structure,politeness,Face,Acknowledgments
- چکیده:
- چکیده انگلیسی: This contrastive study, in the first place, examined the generic structure and, in the second place, explored the face theory proposed by Arundale (2006) in 140 doctoral dissertation acknowledgments written by native speakers of Persian (NSP) and native speakers of English (NSE) in 7 disciplines representing soft sciences to find out what discourse genre components writers employ to articulate the communicative purpose of these acknowledgments. The results of the first phase of the study revealed four moves and a number of constituting steps. Careful surveillance uncovered an obligatory acknowledging move framed by two optional resonating and declaration moves. The findings related to the second phase of the study discovered that, approximately, majority of moves and steps exploited by the two groups function as connection face except for the shouldering responsibility step voiced as separation face. Persian writers, guided by their different cultural and literacy practices, utilized this step more than English writers. The study provided valuable information about the academic values, socio-cultural practices, and personal identity of the writer encoded in the rhetorical and organizational components of this genre.
- انتشار مقاله: 30-02-1392
- نویسندگان: Alireza Jalilifar,Mohammad Javad Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Carbon Monoxide,Cement Plant,Gaussian Model
- چکیده:
- چکیده انگلیسی: The objective of our study was to simulation of carbon monoxide (CO) dispersion exited from the stacks of a cement industry of Doroud, Iran by Gaussian Model (GM). Four sampling period was conducted to measurement of CO from the factory's three-stack flow during one year. The input parameters for were the rate of CO emission, meteorological data, factors of related to the stack, and factors of related to the receptor. Parameters were corporate and the dispersion of CO during four season was modeled. The southwesterly winds were dominated during recently five years. The highest and the lowest CO levels were estimated at spring and fall seasons with maximum amounts of 842.06 and 88.31 µg/m3 within distances of 526 and 960 m away from the cement plant, respectively. Although, the maximum predicted CO concentration at four seasons were lower than the NAAQS standard, the simulation results can be used as a base for reduction of CO emissions rate, because the long-term exposure to emissions of cement plant imposes potentially significant health and environmental impacts.
- انتشار مقاله: 04-06-1395
- نویسندگان: Gholamreza Goudarzi,Rajab Rashidi,Mohammad Javad Mohammadi,Shahram Sadeghi,Mehdi Amidnia,Yusef Omidi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Ahvaz,Water Distribution Network,Failures Analysis
- چکیده:
- چکیده انگلیسی: Failures in the water distribution network are some most important factors in water losses, water shortage and dissatisfaction of users and secondary pollutions as well. This research aimed to analyze failure in water distribution networks during 2006-2008, for better water management. Daily failure reports in Ahvaz, Iran distribution network during 2006-2008, were collected from emergency department of Ahvaz water and Wastewater Company; thereafter, they were entered into an Excel database, also failures were defined by pipes type, pipe diameter, and cause of the failure, and finally the data were analyzed. Results indicated that asbestos and polyethylene pipes show maximum failures; maximum failure and fracture has occurred in pipes with 100 and 150 mm diameters. The most important factors affecting on failure were corrosion, traffic load and landslide. In addition, simultaneous influence of type and the diameter of the pipe on the failures were statistically significant. The depth of pipes establishment, corrosion and obsolescence of pipes as well as improper type of pipes were the most important causes of failures in Ahvaz Water Distribution Network. In this regard, upgrading pipe material setting standards and renewing water pipe network are the main strategies for failures minimization.
- انتشار مقاله: 10-06-1392
- نویسندگان: Mehdi Ahmadi,Mohammad-Javad Mohammadi,Kambiz Ahmadi-Angaly,Ali-Akbar Babaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Carbon Monoxide,Cement Plant,Gaussian Model
- چکیده:
- چکیده انگلیسی: The objective of our study was to simulation of carbon monoxide (CO) dispersion exited from the stacks of a cement industry of Doroud, Iran by Gaussian Model (GM). Four sampling period was conducted to measurement of CO from the factory's three-stack flow during one year. The input parameters for were the rate of CO emission, meteorological data, factors of related to the stack, and factors of related to the receptor. Parameters were corporate and the dispersion of CO during four season was modeled. The southwesterly winds were dominated during recently five years. The highest and the lowest CO levels were estimated at spring and fall seasons with maximum amounts of 842.06 and 88.31 µg/m3 within distances of 526 and 960 m away from the cement plant, respectively. Although, the maximum predicted CO concentration at four seasons were lower than the NAAQS standard, the simulation results can be used as a base for reduction of CO emissions rate, because the long-term exposure to emissions of cement plant imposes potentially significant health and environmental impacts.
- انتشار مقاله: 04-06-1395
- نویسندگان: Gholamreza Goudarzi,Rajab Rashidi,Mohammad Javad Mohammadi,Shahram Sadeghi,Mehdi Amidnia,Yusef Omidi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: chromosomal abnormality,Recurrent abortion,Cytogenetic
- چکیده:
- چکیده انگلیسی: Objective: Approximately 15-20% of clinically recognizable pregnancies end in spontaneous abortion. The incidence of chromosomal abnormalities in those abortions is as high as 50%.A modest but clinically important proportion of spontaneous abortions is caused by a balanced chromosomal aberration in one of the parents. This results from the production of gametes and embryos with unbalanced chromosome sets. The clinical consequences of such abnormal gametes include sterility, recurrent abortions, and giving birth to malformed children. Until now, no such studies have been done in Khozestan province. Therefore, the purpose of this study was to evaluate the frequency and nature of chromosomal abnormalities that lead to recurrent abortions in Khozestan province, which should help physicians working in the region to realize the contribution of chromosomal abnormalities to cases of repeated fetal loss. Also it compares our region to other countries and research centers. This research study evaluated 142 cases with repeated abortion during 1-year period of the study. Methods and Materials and methods: For routine cytogenetic analysis, 3 ml of peripheral blood was incubated in complete lymphocyte culture medium and colchicine was added at prophase stage for fixing chromosomes. Then, they were categorized by G-banding method. Results: A total of 116 cases with a history of recurrent abortions were examined in this research study. The age of the referred women ranged from 20 to 43 years with an average of 28 years (SD = 4.75). Meanwhile, the age of referred men ranged from 22 to 44 years and with an average of 32.8 years (SD = 4.86). The number of previous abortions varied from 2 to 5 abortions (an average of 2.82 abortions per case). In addition, 8 females (12.7%) and 6 males (11.3%) were found to have abnormal karyotypes. These abnormalities were four balanced translocations, one deletion, one inversion and eight mosaic condition. Among cases with abnormal karyotype, the average of maternal age was 29 years (SD = 3.25). Meanwhile, the average number of abortions for cases with abnormal karyotype was 3.07 (SD = 0.83). Conclusion: The correlation for maternal age and chromosomal abnormality was P=0.083 and for the number of abortions and chromosomal abnormality was P=0.107.
- انتشار مقاله: 06-07-1393
- نویسندگان: Iran Rashidi,Javad Mohammadi Asl
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Bilirubin,neonate,Hyperbilirubinemia,Clofibrate
- چکیده:
- چکیده انگلیسی: Background: Clofibrate is a pharmacological agent, which affects the lipid metabolism. This compound could be involved in bilirubin accumulation and excretion process. Therefore, this study aimed to evaluate the effect of oral clofibrate intake on total serum bilirubin (TSB) of neonates hospitalized at Khatam Hospital. Methods: This clinical trial was conducted on 73 neonates with hyperbilirubinemia. Samples were divided into clofibrate (n=41) and control (n=32) groups. In the Clofibrate group, samples were given a single oral dose of 100 mg/kg clofibrate, whereas the control group received distilled water in an equal amount and color as placebo. Birth weight, type of delivery, gender, age and primary TSB level were recorded prior to the intervention and TSB was measured 24, 48 and 72 hours after the intervention. Results: In this study,no significant difference was observed between the groups on the first and third day of intervention in terms of mean TSB in neonates. However, a significant reduction was found on the second day in mean TSB of neonates, who received clofibrate (P=0.04). Conclusion: According to the results of this study, application of clofibrate was associated with faster alleviation of mean TSB and shorter duration of hospital stay without major side effects. Therefore, it is recommended that clofibrate be only used for clinical management of neonatal hyperbilirubinemia.
- انتشار مقاله: 25-12-1394
- نویسندگان: Mahmood NouriShadkam,Mohmmad Javad Mohammadi,Khadijeh Nasiriani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Prevalence,Primary Immunodeficiency Disorders
- چکیده:
- چکیده انگلیسی: Background: Primary immunodeficiency disorders (PID) are a group of hereditary disorders characterized by an increased susceptibility to severe and recurrent infections, autoimmunity, lymphoproliferative disorders, and malignancy.
Objective: To evaluate the demographic and clinical data of PID patients diagnosed in a referral pediatric hospital.
Method: All PID cases with a confirmed diagnosis, according to the criteria of International Union of Immunological Societies, who were referred to the Children’s Medical Center in Tehran, Iran, between March 2006 and March 2013 were enrolled in this retrospective cohort study.
Results: Three-hundred and seven PID patients were investigated. Predominantly antibody deficiencies were the most common group of PID observed in 118 cases (38.4%), followed by the well-defined syndromes with immunodeficiency in 52 (16.9%), congenital defects of phagocyte in 45 (14.7%), combined immunodeficiencies in 36 (11.7%), autoinflammatory disorders in 34 (11.4%), immune dysregulation in 11 (3.6%), complement deficiencies in 7 (2.3%), and defects in innate immunity in 3 (1%). Selective IgA deficiency was the most prevalent disorder which affected 46 individuals (14.9%). The median diagnostic delay was 15 months.
Conclusion: Increased awareness and availability of diagnostic tests could result in the better recognition of more undiagnosed PID cases and a decrease in diagnostic delay.- انتشار مقاله: 15-05-1395
- نویسندگان: Payam Mohammadinejad,Babak Mirminachi,Bamdad Sadeghi,Masoud Movahedi,Mohammad Gharagozlou,Javad Mohammadi,Hassan Abolhassani,Nima Rezaei,Asghar Aghamohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Whole exome sequencing,Charcot-marie tooth disease,Dystrophin-related protein 2 gene (DRP2),Genetic heterogeneity,Hereditary sensory and Motor neuropathy
- چکیده:
- چکیده انگلیسی: Objective(s): Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencing (WES) to capture all the exons may help to find these genes.
Materials and Methods: Here, we tried to find the genetic cause of the neuropathy in two Iranian brothers using WES. Blood sample was collected from probands and their family members to extract the genomic DNA. The extracted DNA from one of the affected case was subjected for WES. The variant calls were filtered to reveal the pathogenic variant. Presence of the candidate mutation was confirmed using Sanger sequencing. The pathogenic potential of the variant was examined using in silico software. Using ClustalW multiple alignment, the presence of variant in conserved domain of protein was investigated. The parent and another affected boy were also checked for presence of the variant using PCR-sequencing.
Results: The obtained data presented a novel TTC del mutation in CDS 738 of dystrophin related protein 2 (DRP2) gene, which was validated by sequencing. The variant was located in a conserved domain of DRP2 protein and predicted as pathogenic. Two affected boys were hemizygous for the mutation and received the mutation from mother.
Conclusion: Here, we provided the evidence for the contribution of DRP2 in CMT. Also, the symptoms shed light on molecular aspect of this genetically heterogeneous disease.- انتشار مقاله: 05-01-1397
- نویسندگان: Maryam Tahmasebi Birgani,Mohammadreza Hajjari,Neda Golchin,Bita Shalbafan,Javad Mohammadi-Asl,Forouzan Sadeghian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Whole exome sequencing,Charcot-marie tooth disease,Dystrophin-related protein 2 gene (DRP2),Genetic heterogeneity,Hereditary sensory and Motor neuropathy
- چکیده:
- چکیده انگلیسی: Objective(s): Charcot-Marie Tooth disease (CMT) is one of the main inherited causes of motor and sensory neuropathies with variable expressivity and age-of onset. Although more than 70 genes have been identified for CMT, more studies are needed to discover other genes involved in CMT. Introduction of whole exome sequencing (WES) to capture all the exons may help to find these genes.
Materials and Methods: Here, we tried to find the genetic cause of the neuropathy in two Iranian brothers using WES. Blood sample was collected from probands and their family members to extract the genomic DNA. The extracted DNA from one of the affected case was subjected for WES. The variant calls were filtered to reveal the pathogenic variant. Presence of the candidate mutation was confirmed using Sanger sequencing. The pathogenic potential of the variant was examined using in silico software. Using ClustalW multiple alignment, the presence of variant in conserved domain of protein was investigated. The parent and another affected boy were also checked for presence of the variant using PCR-sequencing.
Results: The obtained data presented a novel TTC del mutation in CDS 738 of dystrophin related protein 2 (DRP2) gene, which was validated by sequencing. The variant was located in a conserved domain of DRP2 protein and predicted as pathogenic. Two affected boys were hemizygous for the mutation and received the mutation from mother.
Conclusion: Here, we provided the evidence for the contribution of DRP2 in CMT. Also, the symptoms shed light on molecular aspect of this genetically heterogeneous disease.- انتشار مقاله: 05-01-1397
- نویسندگان: Maryam Tahmasebi Birgani,Mohammadreza Hajjari,Neda Golchin,Bita Shalbafan,Javad Mohammadi-Asl,Forouzan Sadeghian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Melatonin,Transplantation,Cryopreservation,Spermatogonial stem cells
- چکیده:
- چکیده انگلیسی: Objective(s):Transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. Melatonin is secreted from the pineal gland and some organs such as testes. According to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantation quality. The aim of this study was to investigate the effects of melatonin on the spermatogonial stem cells transplantation in the azoospermic mice. Materials and Methods: The testes of the BALB/c mice pups (6-day-old) after vitrified-thawed, were digested with enzymes (collagenase, DNaseΙ, trypsin-EDTA) to disperse the cells. The SSCs, type A, were isolated from the rest of testicular cells by MACS. Spermatogonial stem cells were labeled with PKH26 fluorescent kit. Labeled spermatogonial stem cells were transplanted into the testes of infertile mice (busulfan 40 mg/kg). The mice died two months after transplantation and the efficiency of spermatogenesis was investigated. TNP2 and hematoxyline-eosin staining were used to detect the efficiency of cell transplantation. Results: TNP2 were detected in the samples that received melatonin and spermatogonial stem cells transplantation, simultaneously. TNP2 was not detectable in the transplant recipient mice that received placebo for 10 weeks (control group). According to hematoxyline-eosin staining, melatonin improved structure of testes. Conclusion: Administration of melatonin (20 mg/kg) simultaneously with transplantation of spermatogonial stem cells in azoospermia mouse testis increases the efficiency of transplantation and improves structural properties of the testes tissue.
- انتشار مقاله: 29-11-1392
- نویسندگان: Mohammadreza Gholami,Ghasem Saki,Masoud Hemadi,Ali Khodadadi,Javad Mohammadi-asl
- مشاهده