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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Ovarian Cancer,Adnexal mass,Prediction score,risk scoring
- چکیده:
- چکیده انگلیسی: Objective: To develop and validate a simplified multi-parameter risk-based scoring system for preoperative diagnosis
of early stage epithelial ovarian cancer. Methods: All women presented with adnexal mass and were scheduled for
operation at Phrapokklao hospital during September 2013 – December 2017 were included and categorized according
to their histopathologic reports into early stage ovarian cancer groups and benign ovarian tumor groups. Multivariable
logistic regression was used to explore for potential predictors. The selected logistic coefficients were transformed
into risk-based scoring system. Internal validation was done with bootstrapping procedure. Results: A total of 270
participants were included in analysis and predictive model development, 54 in early stage ovarian cancer group and
216 in benign ovarian tumor group. Menopausal status, two abnormal ultrasound findings (presence of solid component
or ascites), tumor size and serum CA-125 level were used for derivation of the scoring system. The score-based model
showed area under ROC of 0.88 (95%CI 0.82-0.93). The developed scoring system ranged from 0 to 51 was classified
into 3 subcategories for clinical practicability. The positive predictive values for the presence of early stage ovarian
cancer were 2.07 (95%CI 0.43-6.05) for low risk patient, 29.13(95%CI 19.65-41.58) for moderate risk patient, and
95.45(95%CI 77.16-99.88) for high risk patient. Conclusion: This simplified risk-based scoring system for preoperative
diagnosis of early stage ovarian cancer could aid general physicians or general gynecologists in evaluation of patients
presenting with ovarian tumors and help gynecologic oncologists in management planning and prioritization of patients
for operation.- انتشار مقاله: 25-08-1397
- نویسندگان: Watcharin Chirdchim,Preecha Wanichsetakul,Phichayut Phinyo,Jayanton Patumanond,Komsun Suwannarurk,Jatupol Srisomboon
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Uterine cervix,high‐grade squamous intraepithelial lesions,Younger women
- چکیده:
- چکیده انگلیسی: Objective: To determine the factors associated with the increased risk of developing high-grade squamous
intraepithelial lesions (HSIL) of the uterine cervix in women younger than 30 years compared with those aged ≥ 30
years who also had HSIL. Methods: Patients with HSIL who underwent loop electrosurgical excision procedure (LEEP)
between January 2006 and July 2017 at Chiang Mai University Hospital were retrospectively reviewed. We analyzed
the factors associated with the development of HSIL by comparing two age groups between women aged < 30 years
and those aged ≥ 30 years. The factors analyzed included the well-recognized risk factors for cervical cancer, i.e. age
at sexual debut, number of sexual partners, use of oral contraceptive (OC) pills, smoking history, sexually transmitted
diseases and HIV status. Univariate and multivariate logistic regressions were used to assess factors associated with
the increased risk of developing HSIL in women younger than 30 years compared with those aged ≥ 30 years. Results:
During the study period, there were 345 patients with HSIL, 30 were < 30 years (case group) and 315 aged ≥ 30 years
(control group). By multivariate analyses , early sexual debut(OR, 2.86; 95% CI, 1.01-8.13; P=0.047), multiple sexual
partners (OR, 2.94; 95% CI, 1.23-7.02; P=0.015), history of genital warts (OR, 20.46; 95% CI, 2.27-183.72; P=0.007)
and history of smoking (OR, 2.95; 95% CI, 1.10-7.93; P=0.032) were significantly associated with the development
of HSIL in women younger than 30 years when compared with those aged ≥ 30 years. The OC use, HIV status and
underlying diseases were not significantly different in both groups. Conclusion: Early age at sexual debut, multiple
sexual partners, history of genital warts and smoking are significant risk factors for developing HSIL in women younger
than 30 years. Cervical cancer screening should be considered in young women with such factors.- انتشار مقاله: 12-11-1396
- نویسندگان: Jongpeeti Wudtisan,Charuwan Tantipalakorn,Kittipat Charoenkwan,Rung‐Aroon Sreshthaputra,Jatupol Srisomboon
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Uterine cervix,Adenocarcinoma in situ,cervical screening results
- چکیده:
- چکیده انگلیسی: Background: Adenocarcinoma in situ (AIS) of the uterine cervix is a preinvasive lesion of the invasive
adenocarcinoma. We analyzed the cervical screening results leading to detecting the AIS lesions including the coexistence
of AIS lesions with high-grade squamous intra-epithelial lesions (HSIL) and invasive carcinoma. Methods:
Women who were diagnosed and received treatment for AIS at Chiang Mai University Hospital between January 1,
2007 and August 31, 2016 were retrospectively reviewed. The inclusion criteria were the women who had pathological
diagnosis of AIS obtained from cervical punch biopsy or excisional cone biopsy with either loop electrosurgical excision
procedure (LEEP) or cold-knife conization (CKC). The patient characteristics, diagnostic work-up and treatment details
were reviewed, including the cervical screening results prior to the diagnosis of cervical AIS, pathologic results of
excisional cone biopsy and hysterectomy specimens. Results: During the study period, 75 women with AIS pathology
undergoing excisional cone biopsy with either LEEP (n=62) or CKC (n=13) were identified. The abnormal cytologic
screening leading to detection of AIS was the squamous cell abnormality accounting for 57.3%. Abnormal glandular
cytology accounted for 37.3%. The most common abnormal cervical screening results was HSIL cytology (n = 25)
followed by AIS cytology (n = 13). Normal cytology was noted in 4 women in whom 3 were positive for HPV 18
and 1 had AIS on the endocervical polyp. AIS coexisted with HSIL and invasive carcinoma were detected in cone
biopsy specimens in 21 (28%) and 29 (38.7%) patients, respectively. Conclusion: The majority of cervical screening
results leading to detection of cervical AIS was the squamous cell abnormality accounting for 57.3% in which, HSIL
cytology was the most common. Abnormal glandular cytology accounted for only 37.3%. Diagnostic cone excision is
recommended if AIS lesion is noted in cervical biopsy specimen since nearly 40% have coexisting invasive lesions.- انتشار مقاله: 05-07-1397
- نویسندگان: Santipap Srisomboon,Charuwan Tantipalakorn,Kittipat Charoenkwan,Jatupol Srisomboon
- مشاهده