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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Saliva,gram negative bacteria,Hepatic disorder
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Liver cirrhosis is the end stage of liver failure. It is mentioned as one of the main etiologies of morbidity and mortality in the world. The human salivary bacteria may induce oral disorders and interact with other body microbiota.
Purpose: The aim of the present study is to identify the pathogenic bacteria of non-oral origin from the saliva samples of patients with end stage liver failure.
Materials and Method: In this cross-sectional study, the saliva samples of 88 end stage liver disease cases and 84 age- and sex-matched healthy subjects were collected. The samples were cultured using gram staining and API20E Kit.
Results: According to the statistical analysis, the total amount of the non-commensal bacteria was significantly higher in chronic liver failure (CLF) group than controls (p = 0.001). There was no significant difference between both groups for the presence of other bacteria (p = 0.001) except for Escherichia coli (E. coli). E. coli was isolated from the saliva of 15 cases and only 2 controls.
Conclusion: Oral cavity may act as a reservoir for enteric bacteria such as E. coli in liver failure patients. Adequate oral and general hygiene might reduce the risk of systemic infection especially in immunocompromised cases.- انتشار مقاله: 26-08-1397
- نویسندگان: Janan Ghapanchi,Abdollah Bazargani,Hooman Khorshidi,Maryam Erfani,Fahimeh Rezazadeh,Azita Azad,Reza Derafshi,Ahmad Hassan Kalantari
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: The rate of antibiotic resistance in bacteria and side effects of antibiotics and oral and teeth health care products are increasing. Therefore, researchers aim at finding new alternatives to control bacteria of dental caries.Purpose: The objective of this study was to investigate the inhibitory and bactericidal effects of different concentrations of zinc sulfate and zinc acetate solutions on the main recognized agent of dental caries, Streptococcus mutans.Materials and Method: In this experimental study, different concentrations of aqueous zinc sulfate and zinc acetate solutions were prepared and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of these salts for Streptococcus mutans were determined in compare with penicillin, chlorhexidine by micro-serial dilution method. In addition, the diameters of zone of inhibition for these salt solutions in four concentrations along with chlorhexidine, as the control, were detected by the disc diffusion method.Results: MIC and MBC of zinc sulfate solution were higher than penicillin and chlorhexidine. There were not statistically significant differences between the MIC and MBC of zinc acetate solution, penicillin, and chlorhexidine. In 25 and 50 µg/mL concentrations, the diameters of inhibition zone for zinc sulfate were more than zinc acConclusion: Zinc sulfate and zinc acetate salts with 37.19 and 31.25 µgr/mL concentration had inhibitory effect on Streptococcus mutans growth respectively, although, no priority in antibacterial activity of the studied zinc salts was determined in comparison with penicillin and chlorhexidine.Key Words Zinc sulfate; Zinc acetate; Streptococcus mutans
- انتشار مقاله: 09-11-1395
- نویسندگان: Fatemeh Lavaee,Janann Ghapanchi,Mohammad Motamedifar,Maryam Sharifzade Javidi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient’s discomfort.Purpose: The purpose of the present clinical trial is to assess the effect of low and high level laser therapy on pain control and wound healing of RAS.Materials and Method: Thirty six patients with minor RAS were divided into three groups. Group 1 (n=14) received CO2 laser, group 2 (n=12) were treated with InGaAlP Diode laser and group 3 (n=10) received sham laser as placebo. All patients were evaluated daily up to 15 days after receiving one session of laser therapy. Pain severity before and after treatment, wound healing, patient’s satisfaction, and functional disturbance before and after treatment were recorded for each patient.Results: According to statistical analysis, pain reduction after treatment in group 1 was 7.00±2.41, in group 2 was 2.08±2.31, and in group 3 was 1.40±1.77. In addition, a significant difference was observed in the reduction of functional complications in CO2 laser treated patients compared to the other two groups.Conclusion: High-level laser treatment showed analgesic effects on RAS, but no healing was observed. Low-level laser therapy demonstrated no positive effect on recurrent aphthous ulcers. Keywords ● Aphthous ● Stomatitis ● Laser therapy ● Wound healing;
- انتشار مقاله: 30-03-1394
- نویسندگان: Nasim Zeini Jahromi,Janan Ghapanchi,Sara Pourshahidi,Maryam Zahed,Hooman Ebrahimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Oral candidiasis is the most common opportunistic infection affecting the human oral cavity. Photodynamic therapy, as one of its proposed treatment modalities, needs a distinct dye for achieving the best effect.Purpose: The purpose of this study was to evaluate photosensitization effects of four distinct dyes on standard suspension of Candida albicans (C. albicans) and Candida dubliniensis (C. dubliniensis) and biofilm of C. albicans considering the obtained optimum dye concentration and duration of laser irradiation.Materials and Method: In this in vitro study, colony forming units (CFU) of two sets of four groups of Laser plus Dye (L+D+), Dye (L-D+), Laser (L+D-) and No Laser, No Dye (L-D-) were assessed individually with different methylene blue concentrations and laser irradiation period. The photodynamic therapy effect on standard suspension of Candida species (using methylene blue, aniline blue, malachite green and crystal violet) were studied based on the obtained results. Similar investigation was performed on biofilm of C. albicans using the spectral absorbance. Data were imported to SPSS and assessed by statistical tests of analysis of variance (ANOVA) and Tukey test (α= 0.05).Results: CFU among the different dye concentration and irradiation time decrease in dose- and time-dependent manner (p> 0.05), all of which were significantly lower than the control groups (p< 0.05). Among the examined photosensitizers, there was no statistically significant difference, (p> 0.05) though all of them were significantly decrease CFU compared with the control groups (p< 0.05). In L+D- and L+D+ groups, biofilm was significantly destroyed more than that of L-D- (p< 0.05).Conclusion: Photodynamic therapy might be used as an effective procedure to treat Candida associated mucocutaneous diseases and killing biofilm in the infected surfaces such as dentures. Keywords ● Candida albicans ● Candida dubliniensis ● Laser ● Photodynamic Therapy
- انتشار مقاله: 25-03-1394
- نویسندگان: Nasim Hosseini,Samira Yazdanpanah,Maryam Saki,Fahimeh Rezazadeh,Janan Ghapanchi,Kamiar Zomorodian
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Single Nucleotide Polymorphism,Oral lichen planus,programmed cell death protein,Autoimmune Disease
- چکیده:
- چکیده انگلیسی: Background: The association between programmed cell death protein 1 (PD-1) variations and susceptibility to
autoimmune diseases has been recurrently reported. However, there is no report about its relationship with oral lichen
planus (OLP) as one of autoimmune diseases. Methods: We investigated the association between genetic predisposition
to OLP and two single nucleotide polymorphisms in PD-1. Results: GG, GA, and AA genotypes at position +7146
were found in 59 (80.8 %), 10 (13.7 %), and 4 (5.5 %) patients, and in 132 (77 %), 34 (20 %), and 5 (3 %) healthy
participants. CC, CT, and TT genotypes at position +7785 were found in 32 (43.8 %), 35 (47.9 %), and 6 (8.2 %) patients
and in 99 (58 %), 66 (39 %), and 6 (3 %) controls. Analysis indicated that patients’ genotypes were not statistically
different from controls’ genotypes at both positions +7146 (P = 0.35 and P = 0.98) and +7785 (P = 0.07 and P = 0.06).
Conclusion: The findings indicated that PD-1 SNPs at +7146 [PD-1.3] G/A and +7785 [PD-1.5] C/T was not associated
with susceptibility to OLP. However, further research with higher sample size and in different geographical regions is
needed in order to achieve the generalizability of the findings.- انتشار مقاله: 30-10-1396
- نویسندگان: Janan Ghapanchi,Hamid Ghaderi,Mohammad Reza Haghshenas,Samira Jamshidi,Fahimeh Rezazadeh,Azita Azad,Mitra Farzin,Reza Derafshi,Ahmad Hasan Kalantari
- مشاهده