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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Risk Factor,premature neonate,Retinopathy of prematurity,Low birth weight
- چکیده:
- چکیده انگلیسی: Background & Aims: Retinopathy OF prematurity (ROP) is a developmental disorder of retinal vessels in premature neonates. In recent years, because of advances in the care of neonates hospitalized in equipped Intensive care units, retinopathy of prematurity has become a major cause of blindness in those who are survived. This study assessed the incidence and severity of retinopathy and related risk factors in premature infants in Bo-Alisina and Emam Khomeini Hospitals in Sari. Methods: This was a descriptive cross-sectional study conducted for one year. All neonates hospitalized in NICU and neonatal wards of selected Hospitals with a gestational age less than 30 weeks or gestational age less than 34 weeks with unstable conditions were included for clinical and laboratory studies. Result: The incidence of ROP in 146 studied neonates was 16.4% (24 cases), of which 6 cases were of grade 1, 14 cases of grade 2 and four cases were grade 3. All four cases with grade 3 ROP were recovered with injection of intravitreal avastin or without medical therapy. Sixty six percent of patients with ROP, had a gestational age of less than 30 weeks and all of them had birth weights less than 2000grams. There was statistical correlation between the incidence of ROP and gestational age, birth weight, history of intubation, Intraventricular hemorrhage, PH <7.2, history of high or low blood pressure and fraction of inspired oxygen in newborns. But, no significant relationship was found between duration of oxygen therapy, history of sleep apnea, Resuscitation, sepsis and duration of Phototherapy with ROP. Conclusions: The incidence of retinopathy of prematurity in Bo-Alisina and Emam Khomeini Hospitals in Sari was similar to other studies. The most important risk factors were low gestational age and birth weight. Considering the risk of the disease in premature infants, ROP screening is recommended not only for prematures under 30 weeks of gestational age but also in more mature ones who have any risk factor for ROP.
- انتشار مقاله: 22-04-1395
- نویسندگان: Maryam Nakhshab,Ahmad Ahmadzadeh Amiri,Sharareh Dargahi,Roya Farhadi,Jamshid Yazdani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: immunohistochemistry,Mutation,RAF gene,Pigmented skin neoplasm
- چکیده:
- چکیده انگلیسی: Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.
Methods: 82 paraffin-embedded blocks, including melanocytic nevi, malignant melanoma, Basel cell carcinoma, and squamous cell carcinoma were evaluated for BRAF V600E expression by immunohistochemistry in the patients admitted to Ibn Sina Hospital, in the city of Sari, Mazandaran province, North of Iran. The evaluation of immunohistochemical staining was performed by two of the authoring pathologists, and staining intensity was graded from negative (0), weak (1+), moderate (2+) to strong (3+). If twenty percent (or greater) of the tumor cells showed modest to strong cytoplasmic immunoreactivity (score 3+), the neoplasm was considered positive for this tumor marker.
Results: Among 82 studied patients, 12 cases (60%) of the malignant melanoma group revealed a high intensity of immunostaining for BRAF V600E, while a significant expression of this marker did not occur in the other investigated skin neoplasm. A great relation between BRAF (V600E) expression and the histologic type of skin cancer was noted. No significant relationship with other parameters such as gender, age, and the grade differentiation of the non-melanoma skin cancer was found. BRAF V600E was weakly correlated with the Clark level of cutaneous malignant melanoma.
Conclusion: This data provided further- انتشار مقاله: 09-09-1378
- نویسندگان: Maryam Ghasemi,Laleh Vahedi-larijani,Omid Emadian,Jamshid Yazdani,Ahmad Sajadianfar,Saeid Abediankenari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Injections,Warts,Intralesional,Measles–mumps–rubella vaccine
- چکیده:
- چکیده انگلیسی: Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the intralesional injection of the measles–mumps–rubella (MMR) vaccine into resistant-to- treatment palmoplantar warts and its complications.Methods: In this single-blind, randomized, controlled clinical trial, 60 cases with resistant-to-therapy palmoplantar warts referring to the Dermatology Clinic of Bou-Ali Sina Hospital of Sari between June 2015 and 2016 were randomly assigned to 2 equal groups: the MMR Group received intralesional MMR and the Placebo Group was given saline injection. The injections were administered at 2-week intervals until complete clearance was achieved or for a maximum of 5 injections (
- انتشار مقاله: 25-02-1396
- نویسندگان: Mohammad Sadegh Rezai,Hiva Ghasempouri,Ozra Asqary Marzidareh,Jamshid Yazdani Cherati,Ghasem Rahmatpour Rokni
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Dental caries,Nitric oxide,Total Antioxidant Capacity,pH,Total protein
- چکیده:
- چکیده انگلیسی: Background: Dental caries is one of the most common oral diseases in pre-school children. Several factors can affect caries process. Aim of this study was comparison of some of the chemical properties of saliva such as total antioxidant capacity, total protein, pH, nitric oxide level in caries free (CF), and caries active (CA) children.
Materials and Methods
This cross-sectional based study was designed with random selection of 80 healthy population including 40 CF and 40 CA children (3-5 years old) from several public kindergartens in Sari, Iranin 2019. Caries status was assessed using DMFT (Decayed/Missing/Filled Teeth) index according to WHO criteria. Un-stimulated saliva samples were collected from children in the morning. Then, several caries-related factors including total antioxidant capacity, nitric oxide, total protein concentration and pH were assessed in saliva samples. Data were analyzed using SPSS software version 16.0.
Results: Significant higher total antioxidant capacity and total protein concentration were observed in the saliva of CA than in the CF children. On the other hand, nitric oxide level was markedly lower in CA samples. In addition, a decrease in pH of saliva was observed in CA children.
Conclusion
Based on the results, increase in the total antioxidant capacity and total protein as well as decrease in nitric oxide levels in the saliva of CA children can be considered as valuable evidence of dental caries occurrence among children.- انتشار مقاله: 13-06-1398
- نویسندگان: Fatemeh Shaki,Milad Arab-Nozari,Faezeh Maleki,Jamshid Yazdani Charati,Azam Nahvi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Student,Malocclusion,Orthodontic treatment
- چکیده:
- چکیده انگلیسی: Background
A malocclusion is a misalignment or incorrect relation between the teeth of the two dental arches when they approach each other as the jaws close. Considering the prevalence of malocclusion and its role in quality of life (QOL), we aimed to investigate the relationship between need of orthodontic treatment and QOL in North Iran students.
Materials and Methods
This is a cross-sectional descriptive-analytical study; the sample size was estimated to be 270 students using a two-stage sampling method. After entering the study, the Orthognathic Quality of Life Questionnaire (OQLQ) was completed for each student. Need of orthodontic treatment was assessed based on the dental health component of index of treatment need (IOTN). SPSS software version 22.0 was used for data analysis.
Results
274 students (133 boys and 141 girls) participated in this study. The mean age was 14.86 ±0.54. The mean QOL scores were 13.31±11.78 and it was not significant statistically in boys and girls (P=0.893). Mean QOL scores were not statistically significant (P = 0.306) according to grade of IOTN. Grade 2 had the highest frequency (37.2%) with the lowest mean score of QOL (11.65±10.31), and Grade 5 had the lowest frequency (2.6%) with the highest mean score of QOL (15.83±7.78). IOTN was not statistically significant in both groups (P>0.05).
Conclusion
In our study, students with dental malocclusion had the lowest QOL, although no significant relationship was observed. Almost a quarter of students needed orthodontic treatment. The most common malocclusion was displacement of contact points.- انتشار مقاله: 08-11-1398
- نویسندگان: Farhad Sobouti,Youssef Kavianpour,Jamshid Yazdani Cherati,Sepideh Dadgar
- مشاهده