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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Carboplatin,Anticancer,1,3- cyclobutane dicarboxylic acid,Platinum complexes
- چکیده:
- چکیده انگلیسی: Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using different methodology to achieve high purity then carboplatin was synthesized from the reaction of the prepared ligand with cisplatin. Purity of prepared carboplatin was confirmed by High-Performance Liquid Chromatography (HPLC). Platinum(II) complex carboplatin,have been characterized with 1H and 13C nuclear magnetic resonance spectra and infrared spectroscopy.
- انتشار مقاله: 06-04-1395
- نویسندگان: Ali Nemati Kharat,Bahareh Tamaddoni Jahromi,Ehsan Mohammadifar,Jaleh Zareyi
- مشاهده