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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: risk stratification,hemodialysis,Hand Grip Strength,Malnutrition-Inflammation Score,Protein- Energy Wasting
- چکیده:
- چکیده انگلیسی: Background: We aimed to detect whether risk stratification of hemodialysis (HD) patients with a combination of both malnutrition-inflammation score (MIS) and hand grip strength (HGS) indices identified more precisely patients at increased risk of protein-energy wasting (PEW). Methods: This was a deductive-analytical cross-sectional study. We determined the HGS and MIS of 83 HD patients who were randomly selected from the dialysis centers in Kerman. Data were analyzed using t-tests and One-way ANOVA. Multinomial logistic regression and receiver operating characteristic (ROC) curve analysis were performed accordingly. Results: There were significant differences between normal and high risk MIS regarding gender, having diabetes mellitus (DM), duration of dialysis, serum albumin, and C-reactive protein (P= 0.021, 0.049, 0.003, 0.038, and 0.027, respectively). There were also significant differences between normal and high risk HGS groups regarding age, having DM, cause of kidney disease (DM and/or hypertension), creatinine level, total cholesterol, weight, height, and mid upper arm circumference (P= 0.000, 0.006, 0.024, 0.011, 0.044, 0.026, 0.014, and 0.029, respectively). The ROC curves of the MIS and HGS indices showed sensitivity and specificity of 89.7% and 93.8%; 78.0% and 72.5%; respectively. Conclusions: Our findings reveal that patients, defined as “normal by both”, “normal by either”, and/or “high risk by both” based on the diagnostic tools, exhibit different markers compared to patients categorized by either index separately. The cutoff of MIS for the occurrence of PEW varied depending on the procedure used. The sensitivity and specificity of MIS and HGS indices were excellent.
- انتشار مقاله: 10-04-1397
- نویسندگان: Mohammad Reza Mahmoodi,Naser Hasheminejad,Abbas Bahrampour,Jalal Azmandian,Mina Namdari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Kidney transplant,Rejection,Cyclosporine,Diltiazem
- چکیده:
- چکیده انگلیسی: Cyclosporine (CsA) is a drug that has been used for prevention of kidney transplant rejection for many years. Diltiazem with the inhibition of cyclosporine metabolism and clearance will increase CsA concentration and CsA dose can be decreased. The aim of this study was the evaluation of diltiazem effect on CsA dose adjustment with respect to C2. Forty stable renal transplant patients who were receiving CsA, prednisolone, mycophenolate mofetile as well as diltiazem were enrolled in the study. At first, minimum concentration of CsA (C0) and concentration within 2 h after dosing (C2) were determined in every patient. These patients were randomly assigned to an 8-week period of continued therapy with diltiazem (20 patients), or to a washout period removing diltiazem from the treatment (20 patients). At the end of this period, CsA concentrations were measured. Thereafter, the groups underwent a crossover followed by either diltiazem washout or reinstituted treatment with diltiazem. Then C0 and C2 were measured. In each step which diltiazem was removed from patient drug regimen, CsA dose was increased by 25%. Finally, we detected that this amount of CsA dose adjustment is suitable in our patients and C0 and C2 remained in the therapeutic windows. Diltiazem co-administration with CsA will be safe and cause decreased patients drug cost.
- انتشار مقاله: 29-06-1389
- نویسندگان: Jalal Azmandian,Seyed Mojtaba Sohrevardi,Faramarz Fazeli,Farhad Sarrafzadeh,Abbas Etminan,Omid Savari,Mojtaba Ghadamzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Dendritic cell,Lupus Glomerulonephritis
- چکیده:
- چکیده انگلیسی: Background & Objectives: Chronicity of lupus nephritis (LN) should be considered for interaction of cell mediated immunity (CMI) and dendritic cells in glomeruli and tubulointerstitial areas. In this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. Materials & Methods: Renal needle biopsies of 35 cases of lupus nephritis and 35 cases of other causes of persistent proteinuria were compared for immunohistochemistry for plasmacytoid (CD123), myeloid (CD11c) dendritic cells, macrophages (CD68) and lymphocytes (CD4) markers. Statistical analysis of the data was performed using Spearman and Pearson correlation or ANOVA and t- student test (P < 0.05). Results:Significant difference of glomerular and interstitial spaces for presence of myeloid-plasmacytoid dendritic cells and lymphocytes except macrophages between lupus nephritis and other causes of persistent proteinuria have found (P<0.001). Positive significant correlations were observed between glomerular presentation of myeloid dendritic cells and chronicity index but not with other markers in lupus nephritis (P <0.001). Statistically significant changes between presence of all markers and activity index were not observed (P >0.05). Conclusions: The myeloid dendritic cells might have synergistic role with other immune cells in pathogenesis and progression or chronicity of lupus nephritis.
- انتشار مقاله: 13-09-1391
- نویسندگان: Shahriar Dabiri,Hadiseh Zakeridana,Manzoumeh Shamsi Meymandi,Abbass Etminan,Jalal Azmandian,Simindokhet Habibzadeh,Farzaneh Khazanfari,Saeideh Parvaresh
- مشاهده