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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Lung cancer,Survival,Statins,Retrospective
- چکیده:
- چکیده انگلیسی: Objectives: Numerous studies addressed the effect of statin on cancer patients. The aim of this study is to define the
effect of statin administration with chemotherapy on the patients’ outcomes. Methods: We retrospectively researched
the database of the University of Cincinnati cancer to identify lung cancer patients who received statins (S+, n=41)
during their treatment in our institute. We also, retrieved data for contemporaneously treated patients who did not
receive statins (S-, n=159) as a control arm. Clinico-demographical data and overall survival (OS) were analyzed using
Pearson’s Chi-square (χ2) test and Kaplan-Meier survival curves with Log-rank test. Adjustment using Cox proportional
hazard ratios (HR) were done based on (age, gender, race and stage) to identify effect of statins on their outcomes.
Results: The median age for S+ was 64y (IQR; 55-69) and 71.2% of the patients were white. Histopathology was
55.4% and 31.7% for adenocarcinoma and squamous cell carcinoma, respectively. Fifty-six percent were stage IV in
each study arm and the median OS was14.9 m. Median OS was insignificantly lower in S–ve arm (13.7 vs 15.6 months;
P=0.652, HR=0.91, 95%CI 0.52-1.57). Our results show that after different types of adjustments, S+ did not show
survival advantage (P>0.05) compared to the control arm. Conclusion: While showing an increase in overall survival
in patients with advanced lung cancer, the results of this study did not reach statistical significance. This could be due
for the small sample size of this retrospective study.- انتشار مقاله: 04-01-1398
- نویسندگان: Ola Gaber,Ihab Eldessouki,Rammey Hassan,Mohamed Magdy,John C Morris,Nagla Abdel Karim
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,Lung cancer,Clear Cell,case serious
- چکیده:
- چکیده انگلیسی: Clear cell carcinomas are common finding in renal, ovarian and uterine carcinomas. However, clear cell lung
cancer (CCLC), first described by Liebow and Castleman in 1963, is considered an extremely rare variant of lung
tumors. The 2011 WHO classification of lung tumors considered CCLC as a rare cytologic feature of squamous cell
or adenocarcinomas. It is no longer recognized as a formal subtype, albeit it can be referred to in the pathological
diagnosis as “with clear cell features” even with marginal fractions of the tumor cells. Such recognition is needed
since the variation in clinical features and outcome in this subset of patients. The disease has a clinically vague natural
history, is characterized by slight female predominance and is often seen in the elderly. As frequently encountered with
rare diseases, its clinical course and treatment options have many questions still yet to be answered. In this paper, we
review both the natural history and treatment options mentioned in literature, in the light of our experience by reporting
a case series of four patients diagnosed with CCLC and highlight their aspects.- انتشار مقاله: 25-11-1396
- نویسندگان: Ihab Eldessouki,Ola Gaber,Muhammad K Riaz,Jiang Wang,Nagla Abdel Karim
- مشاهده