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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Nasopharyngeal carcinoma,incidence rates,global epidemiology
- چکیده:
- چکیده انگلیسی: Background: While nasopharyngeal carcinoma (NPC) is rare in non-endemic regions such as the North America, endemic countries, such as Thailand, continue to struggle with high incidence and mortality rates. NPC has a complex etiology that varies by histological subtype. Methods: NPC cases (1990-2014) were identified using the International Classification of Diseases for Oncology (ICD-O) code C11 from the Chiang Mai, Khon Kaen, Lampang, and Songkhla cancer registries and compared to Asian/Pacific Islanders (A/PI) from the US SEER program. Age-standardized incidence rates and changes in annual percent change (APC) for overall and subtype specific NPC were assessed using R and Joinpoint. Kaplan Meier curves were generated in SAS to evaluate differences in survival by sex, year of diagnosis and histological subtype. Five-year relative survival estimates were calculated between 2000-2014. Results: Non-keratinizing NPC predominated across all registries except Songkhla, where the keretinizing subtype made up ~60% of all reported cases. Incidence of keratinizing NPC significantly decreased among Chiang Mai males between 1996 and 2014 (APC:-13.0 [95%CI:-16.2, -9.6]), Songkhla females (APC:-4.0 [95%CI: -7.4, -0.5]) and males between 2006 and 2014 (APC:-15.5 [95%CI:-25.0, -4.7]), as well as A/PI females (APC:-5.1 [95%CI:-6,7, -3.4]) and males (APC: -4.8 [95%CI:-5.9, -3.7]). Non-keratinizing NPC increased among Songkhla males (APC:4.3 [95%CI:1.8, 6.9]). The keratinizing subtype exhibited the worst survival, while the non-keratinizing undifferentiated subtype had the best survival. Although US A/PI had the highest 5-year relative survival estimates, among the Thai registries Chiang Mai had the best and Lampang the worst survival. Conclusion: Although US A/PIs exhibited similar rates of NPC as seen in the endemic Thai population, improved tobacco control has led to a decrease in keratinizing NPC incidence irrespective of geography. Additionally, while challenges associate with access to care may still exist among rural Thais, chemoradiation was shown to confer a survival benefit in non-keratinizing NPC treatment.
- انتشار مقاله: 10-04-1399
- نویسندگان: Ilona Argirion,Katie R Zarins,Krittika Suwanrungruang,Donsuk Pongnikorn,Imjai Chitapanarux,Hutcha Sriplung,Patravoot Vatanasapt,Laura S. Rozek
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Hepatocellular carcinoma,complete response,predictive factors,selective TACE
- چکیده:
- چکیده انگلیسی: Background: To determine the effectiveness and performance of selective conventional transarterial
chemoembolization (TACE) and analyze the potential predictive factors of sustained complete response (CR) for
patients with hepatocellular carcinoma (HCC). Materials and Methods: Total of 52 patients with HCC (33 males,
19 females; mean age 64.0 ± 9.6 years) who underwent 81 sessions of selective TACE between November 2015 and
March 2017 at Songklanagarind hospital were reviewed. The Kaplan-Meier method was used to describe CR rates at
various time points. Univariate and multivariate logistic regression models were performed to determine the predictive
factors for sustained CR at six months. Results: The CR rates after selective TACE at 1, 4, 6, 9 and 12 months were
87%, 81%, 62%, 40% and 31%, respectively. Univariate and multivariate analyses demonstrated that alpha fetoprotein
level <100ng/ml, a tumor size in summation ≤ 30 mm, ≤ 2 sessions of selective TACE and unilobar involvement had a
significantly higher odds of sustaining complete response at six months (p =0.018, 0.031, 0.032, and 0.044, respectively).
Conclusions: Selective TACE has a good therapeutic results and can sustained complete response in selected HCC
patients. Serum AFP≤ 100 ng/ml, a few sessions of selective TACE, tumor size in summation ≤ 30 mm and unilobar
involvement were favorable predictive factors for sustained complete response of HCC patients.- انتشار مقاله: 25-02-1397
- نویسندگان: Kittipitch Bannangkoon,Keerati Hongsakul,Teeravut Tubtawee,Edward Mc Neil,Hutcha Sriplung,Virasakdi Chongsuwiwatvong
- مشاهده