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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Brand,Corporate reputation,Value creation,Strategic Resource,Corporate Communication,Brand Segmentation
- چکیده:
- چکیده انگلیسی: Abstract
Impact of Corporate Reputation on Brand Segmentation Strategy :
An Empirical Study from Iranian Pharmaceutical Companies
The impact of corporate reputation uses, including value creation, corporate communication and strategic resources on branding strategies such as segmentation and producing intangible assets for different industries is investigated in western countries in the past few years, but there is a gap for the generalizability of findings to countries out of the United Estates and Europe. To establish the western researcher’s external validity of theories in other countries and to obtain a better understanding of the influences of branding and corporate reputation in pharmaceutical business markets, the researchers applied this study for Iran, as a country in the Middle East . The obtained results using SEM ( by P.L.S. 2.0 software ) showed a weak relation between value creation and brand segmentation (β = 0.307 and t-value = 1.806) and no significant relation between corporate communication and strategic resources with brand segmentation (β = 0.199 and t-value = 1.301) and (β = 0.246 and t-value = 1.465 ). Based on these findings; and previous researches in this field, it seems that pharmaceutical managers and marketers need to change their thoughts and practices regarding segmentation and reputation.This study is a pioneering attempt in Iran to evaluate the impact of corporate reputation on brand segmentation strategy.- انتشار مقاله: 01-06-1395
- نویسندگان: Afshin Vahabzadeh,Hossein Vatanpour,Rasoul Dinarvand,Ali Rajabzadeh,Jamshid Salamzadeh,Mehdi Mohammadzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Buthotus schach,Voltage Gated Na Channels,Scorpion Toxin,Whole-Cell Patch Clamp,Current Clamp,Gel Filteration
- چکیده:
- چکیده انگلیسی: Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiological properties of magnocellular supraoptic of hypothalamus by using whole cell patch clamp. In our result were shown, scorpion crude venom and its fraction effect on Na gated voltage channels. A significant decrease was revealed in amplitude firing, in venom various concentration and some of the venom fraction. Also a significant increase was shown in half width and rise time 10% to 90% actions potential firing. Previous evidence was revealed change in electrophysiological properties such as amplitude and rise time 10% to 90%, related to sodium gated voltage channels. Sodium channels toxins existed on scorpion venom caused modulate on sodium channels. In order to access bioactive components, six fractions were collected by gel chromatography techniques. After bath application of fraction, four components were found F2, F3, F4 and F6. Also F2 and F3 component show the same effects than venom on electrophysiological properties of magnocellular supraoptic than venom.
- انتشار مقاله: 07-06-1395
- نویسندگان: Akram Aboutorabi,Nima Naderi,Hamid Gholamipour Pourbadiee,Hossein Zolfagharian,Hossein Vatanpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. The aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of Miconazole on mice fetus brain tissue using FTIR-Microspectroscopy. The mice were injected with Miconazole (60 mg/Kg) on gestation day 9. Fetuses were dissected on day 15 of gestation and morphological and histological studies on the fetus were carried out. Sections (10 μm) of control and Miconazole treated fetus brain tissue were used for FTIR measurement in the mid- infrared region. The results were shown by spectra 2nd derivative and also subtracting from control spectra. A lower intensity in the lipid (2800–3000 cm-1) and amid I (1600–1800 cm-1) regions of Miconazole treated mice fetus brain tissue was observed compared to the control mice fetus brain tissue. No major spectral shifting was observed at amide I band, amide II band and nucleic acid regions. As a conclusion, FTIR-Microspectroscopy can be a useful tool for teratogenic measurement with a unique ability to identify the modified bimolecular structures in mice fetus tissues.
- انتشار مقاله: 26-05-1394
- نویسندگان: Azadeh Ashtarinezhad,Ataollah Panahyab,Baharak Mohamadzadeh Asl,Hossein Vatanpour,Farshad H. Shirazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Mitochondria,Apoptosis,Venom,Colorectal cancer,Naja naja oxiana
- چکیده:
- چکیده انگلیسی:
Objective: To investigate the selective effect of Naja naja oxiana crude venom and its fractions on human colorectal cancer mitochondria to activate apoptosis signaling. Methods: Cells and mitochondria isolated from human cancerous and normal colorectal tissues exposed to N. oxiana crude venom and its fractions obtained from size-exclusion chromatography and then mitochondrial parameters related to up-stream cell death signalling such as reactive oxygen species formation, MMP, mitochondrial swelling, cytochrome c release and ATP content as mitochondrial parameters and activation of caspase3 and finally apoptosis/necrosis % were then assayed as cellular parameters. Result: Our findings indicated that crude venom (15, 30 and 60 μg/ml) and fraction 3; F3; (10, 20 and 40 μg/ml) of N. Oxiana venom induced a significant (p<0.05) increase of reactive oxygen species level, swelling of mitochondria, collapse of mitochondrial membrane potential (MMP), release of cytochrome c, activated caspase3 and decrease ATP content only in colon cancer tissue group but not from the healthy colon tissue group. Our results also showed that fraction 3 of venom decreased the percentage of viable cells and induced apoptosis in cancerous colorectal cells. Conclusion: F3 fraction of N. Oxiana venom is a suitable candidate for further studies as a new drug treatment of colorectal cancer due to its high capacity for induction of apoptosis signaling via mitochondrial pathway.- انتشار مقاله: 14-02-1396
- نویسندگان: Amir Fakhri,Ramesh Omranipour,Sara Fakhri,Mohammadreza Mirshamsi,Fatemeh Zangeneh,Hossein Vatanpour,Jalal Pourahmadjaktaji
- مشاهده