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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Polymorphism,Osteoarthritis,knee,Estrogen receptor gene
- چکیده:
- چکیده انگلیسی: Background: Many studies have reported the association of estrogen receptor α gene (ESRα) ESRα PvuII T>C, XbaI A>G and BtgI G>A polymorphisms with Knee osteoarthritis (KOA) risk, but the results remained controversial. In order to drive a more precise estimation, the present systematic review and meta-analysis was performed to investigate the association between ESRα polymorphisms and KOA susceptibility. Methods: Eligible articles were identified by search of databases including PubMed, ISI Web of Knowledge and Google scholar up to March 1, 2017. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: A total of 22 case-control studies in eleven publications with 6,575 KOA cases and 7,459 controls were included in the meta-analysis. By pooling all the studies, either ESRα PvuII T>C and XbaI A>G polymorphisms was not associated with KOA risk in the overall population. However, ESRα BtgI G>A was significantly associated with KOA risk under all five genetic models. In the subgroup analysis by ethnicity, a significant association was observed between ESRα PvuII T>C polymorphism and KOA risk in Asians under heterozygote model. In addition, significant association was found between ESRα XbaI A>G polymorphism and KOA in Caucasians under allelic, homozygote, dominant and recessive models. Conclusion: The present meta-analysis suggests that ESRα BtgI G>A rather than ESRα PvuII T>C and XbaI A>G polymorphisms is associated with an increased KOA risk in overall population. Moreover, we have found that ESRα PvuII T>C and XbaI A>G polymorphisms associated with KOA susceptibility by ethnicity backgrounds.
- انتشار مقاله: 15-12-1395
- نویسندگان: Masoud Mehdinejad Yazdi,Mohamad H. Jamalaldini,Mohammad R. Sobhan,Mohammadali Jafari,Mahta Mazaheri,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: acute myeloid leukemia,Polymorphism,Mouse Double Minute 2,MDM2 -309T>G
- چکیده:
- چکیده انگلیسی: Background: Genetic factors play a substantial role in acute myeloid leukemia (AML) etiology. Overexpression of the mouse double minute 2 (MDM2) gene has been explored in many tumors. However, the role of MDM2 -309T>G (rs2279744) polymorphism in AML remains unclear. We have performed this study to examine the association of MDM2 -309T>G with AML in an Iranian population. Methods: We have examined the association of N MDM2 -309T>G polymorphism in 73 cases diagnosed with AML and 80 healthy controls by tetra-primer amplification refractory mutation system (ARMS) PCR assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated on the risk genotypes and alleles. Results: The TT, GG and GG genotypes of MDM2 -309T>G polymorphism in patients were 32.9%, 23.2% and 43.9%, while in controls were 86.2%, 7.5% and 6.3%, respectively. Moreover, Frequency of mutant allele (G) was 55.6% in cases with AML and 10.0% in controls. The mutant homozygote genotype (GG) was associated with an increased susceptibility to AML (OR 1.471; 95% CI: 1.062-1.844; p=0.004). Conclusion: Our results showed that the MDM2 -309T>G polymorphism was significantly associated with increased risk of AML in the Iranian population. Thus, the MDM2 -309T>G polymorphism might be useful genetic susceptibility factors in the pathogenesis of AML.
- انتشار مقاله: 16-03-1398
- نویسندگان: Mona Soleymannejad,Mohammad Hassan Sheikhha,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Meta-Analysis,Polymorphism,osteosarcoma,Glutathione-S-transferase
- چکیده:
- چکیده انگلیسی: Background: Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1
polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In
order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate
association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma. Methods: Eligible articles
were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled
using either fixed-effects or random effects models. Results: Finally, a total of 24 case-control studies with 2,405
osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased
osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247
95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In
the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null
vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians. Conclusions: This meta-analysis
demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large welldesigned epidemiological studies are warranted to validate our results.- انتشار مقاله: 13-02-1397
- نویسندگان: Mansour Moghimi,Mohammad Reza Sobhan,Mohammad Hossein Jarahzadeh,Majid Morovati-Sharifabad,Kazem Aghili,Hossein Ahrar,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Polymorphism,Interleukin-10
- چکیده:
- چکیده انگلیسی: Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.- انتشار مقاله: 24-06-1397
- نویسندگان: Mansour Moghimi,Hossein Ahrar,Mojgan Karimi-Zarchi,Kazem Aghili,Marjansadat Salari,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Genetic polymorphism,Susceptibility,ACE I/D
- چکیده:
- چکیده انگلیسی: Background: A number of case-control studies were conducted to investigate the association of angiotensin
converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial.
This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer.
Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge
databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence
intervals (CI) were estimated. Publication bias of literatures was evaluated using funnel plots and Egger’s test. Results:
A total of 20 studies including 2846 breast cancer cases 9299 controls meeting the predefined criteria were involved in
the meta-analysis. Overall, the ACE I/D polymorphisms was significantly associated with breast cancer under the allele
model (I vs. D: OR= 0.803, 95% CI 0.647-0.996, p=0.046), the homozygote model (II vs. DD: OR= 0.662, 95% CI
0.462-0.947, p=0.024), the heterozygote model (ID vs. DD: OR= 0.707, 95% CI 0.528-0.946, p=0.020), the dominant
model (II+ID vs. DD: OR= 0.691, 95% CI 0.507-0.941, p=0.019). In the subgroup analysis by ethnicity, a significant
association was found among Asian and Caucasian populations, but not among mixed populations. Conclusions: This
meta-analysis suggests that ACE I/D polymorphism may be associated with increased risk of breast cancer, especially
among Asian and Caucasians. However, well-designed studies with larger sample size and more ethnic groups are
needed to further validate the results.- انتشار مقاله: 31-02-1397
- نویسندگان: Mansour Moghimi,Saeed Kargar,Mohammad Ali Jafari,Hossein Ahrar,Mohammad Hossein Jarahzadeh,Hossein Neamatzadeh,Jalal Sadeghizadeh-Yazdi
- مشاهده