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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Pain,Morphine,dependence,Nigella sativa,Thymoquinone,Tolerance
- چکیده:
- چکیده انگلیسی: Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice.
Materials and Methods: Male adult NMRI mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 75 mg/kg, i.p. on 9 a.m., 1 p.m., and 5 p.m., respectively) during a 3-day administration schedule. The hot-plate test was used to assess tolerance to the analgesic effects of morphine. Naloxone (2 mg/kg, i.p.) was injected to precipitate withdrawal syndrome in order to assess the morphine dependence. To evaluate the effects of thymoquinone on tolerance and dependence to morphine, different single or repeated doses of thymoquinone were administered in mice. Rotarod was used to assess the motor coordination.
Results: Administration of single or repeated doses of thymoquinone (20 and 40 mg/kg, i.p.) significantly decreased the number of jumps in morphine dependent animals. Repeated administration of thymoquinone (20 and 40 mg/kg, for 3 days) and also single injection of thymoquinone (40 mg/kg, on the fourth day) attenuated tolerance to the analgesic effect of morphine. None of the thymoquinone doses (10, 20, and 40 mg/kg) produced any antinociceptive effects on their own. Motor coordination of animals was impaired by the high dose of thymoquinone (40 mg/kg).
Conclusion: Based on these results, it can be concluded that thymoquinone prevents the development of tolerance and dependence to morphine.- انتشار مقاله: 10-08-1393
- نویسندگان: Hossein Hosseinzadeh,Siavash Parvardeh,Alireza Masoudi,Mahsa Moghimi,Fatemeh Mahboobifard
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Addiction,Traditional Chinese Medicine,Opioid Tolerance,Opioid withdrawal,Traditional Indian Medicine
- چکیده:
- چکیده انگلیسی: Objective: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed.
Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar.
Results: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to) as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance. Moreover, Levo-tetrahydropalmatine and L-Stepholidine, in addition to extracts of Caulis Sinomenii and Sinomenium acutum showed similar effects.
Banxia Houpu Decoction, Fu-Yuan pellet, Jinniu capsules, Qingjunyin, Tai-Kang-Ning capsule, and Xuan Xia Qudu Jiaonang (WeiniCom) from Chinese preparations, showed anti-addiction effects in randomized, double-blind and, in some studies, multicenter clinical trials.
Conclusion: Traditional herbal preparations of China and India have anti-addiction effects with less adverse effects than alpha2-adrenergic or opioid agonists.- انتشار مقاله: 23-08-1391
- نویسندگان: Fatemeh Doosti,Saeedeh Dashti,Seyed Meghdad Tabatabai,Hossein Hosseinzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Morphine,Mice,Aqueous saffron extract,Crocus sativus L,CPP (conditioned place preference)
- چکیده:
- چکیده انگلیسی: Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for four days) 30 min before the morphine administration decreased the acquisition of morphine CPP. In other groups of animal, following extinction of a place preference induced by morphine (40 mg/kg), single administration of morphine (10 mg/kg) reinstated the place reference. The aqueous extract (80 mg/kg) 30 min before this priming dose of morphine blocked morphine-induced reinstatement of place preference. Results: These results show that aqueous saffron extract can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.
- انتشار مقاله: 12-06-1390
- نویسندگان: Hossein Hosseinzadeh,Mohsen Imenshahidi,Alireza Arasteh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: toxicity,Artemia salina,Psoralea drupacea,Phototoxicity
- چکیده:
- چکیده انگلیسی: Objective: Phototoxicity is a kind of dermatitis that is activated by exposure to ultraviolet light following the administration of some drugs or natural products. Artemia salina (A. salina) (brine shrimp) has been effectively applied for toxicity testing and is perfect for biological screening of many chemicals for simultaneous evaluation of toxicity and phototoxicity. The objective of this study was to investigate the phototoxic activitiy of the methanolic extract and chloroform and CH3OH/H2O2 fraction of Psoralea drupacea (P. drupacea). Materials and methods: The phototoxic effect of the methanolic extract, chloroform and CH3OH/H2O2 fractions of P. drupacea was evaluatedusing A. salina bioassay system. Different concentrations of methanolic extract and fractions of P. drupacea were added to the plate of one-day old larvae followed by exposure to UV radiation at 366 nm in three different exposure times (0, 4 and 20 h). Mortality was determined 24h after the start of the irradiation. Results: The value of LC50 of P. drupacea methanolic extract and methoxalen as positive control were 0.64 and 3.5´10-4 mg/ml, respectively. P. drupacea methanolic extract and chloroform fraction demonstrated phototoxic activity after 4 h radiation. Conclusion: The result showed that P. drupacea methanolic extract and chloroform fraction have phototoxicity in A. salina bioassay system and their toxic effect is related to phototoxic constituents such as psoralen.
- انتشار مقاله: 02-11-1391
- نویسندگان: Mohammad Ramezani,Hossein Hosseinzadeh,M. Moradi,E. Taghiabadi
- مشاهده