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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Staphylococcus aureus,enterotoxin genes,pathogenicity,Multiplex-PCR
- چکیده:
- چکیده انگلیسی: Staphylococcus aureus (S. aureus) is a pathogen in community-acquired or hospital infections. Hence, the identification of this pathogen in clinical samples is a health concern and demands continued surveillance and close monitoring. In the current study, S. aureus strains were isolated from various clinical specimens in the Shariati Hospital, Tehran, Iran. Samples were studied to discover S. aureus enterotoxin-coding genes A (sea), B (seb), C (sec), and D (sed). It was found that 21% enterotoxigenic S. aureus harbored sea gene, 39% were carried seb gene, 37% were positive for sec-gene, and 3% were carried sed gene. None of all S. aureus strains harbored more than one of the enterotoxigenic genes. Based on the data obtained from the current study, it could be suggested that seb and sec genes are good candidates for the identification of S. aureus in clinical specimens. Further investigations are required to discover the association between these genes and the pathogenicity of this bacteria, and finally using these data in clinical settings.
- انتشار مقاله: 15-08-1398
- نویسندگان: Vahid Ghanbarinejad,Aboozar Kazemi,Mina Zareei,Reza Heidari,Hossein Hassanian-Moghaddam
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Infection,toxicity,Central nervous system,lead
- چکیده:
- چکیده انگلیسی: Although lead pollution has long been known as a cause of poisoning, it has remained a challenge to reliably diagnose it due to its common symptoms in various diseases. In this article, we report two cases of acute loss of consciousness due to the ingestion of opium-contaminated with lead. The reported cases share patterns of symptoms similar to meningitis and encephalitis which are usual etiology for the loss of consciousness. Lead poisoning is not a usual etiology for loss of consciousness and is considered in cases of occupational or environmental exposure. These reported cases showed a pattern similar to meningitis and encephalitis, but due to the unusual manifestations during their admission and coexistence with gastrointestinal symptoms, we were led to consider poisoning as the cause of consciousness loss. Lead poisoning often goes unrecognized due to a low index of suspicion, but it may turn out to be fatal. Therefore, it should be considered in the differential diagnosis of any neurobehavioral deficits in substance abusers.
- انتشار مقاله: 26-01-1397
- نویسندگان: Minoosh Shabani,Maryam Nasiri,Zohreh Aminzadeh,Hossein Hassanian-Moghaddam
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Poisoning,Epidemiology,Poison Control Centers
- چکیده:
- چکیده انگلیسی: Background: Acute poisoning has been reported to be the most common reason for hospitalization in Iran. This study was designed to delineate the toxic agents responsible for acute poisonings in Iran by reviewing poisoning cases treated at four major referral hospitals for treatment of poisoning across the country. Methods: This was a descriptive retrospective study on poisoned patients treated at four tertiary hospitals referral for poisoning in Iran, including Loghman Hakim Hospital (LHH) in Tehran, Imam Reza Hospital (IRH) in Mashhad, Noor and Ali Asghar Hospital (NAH) in Isfahan, and Ghaemshahr Razi Hospital (GRH) in Ghaemshahr, as reported to the National Drug and Poison Information Center during the years 2012 and 2013. Results: During the two-year study period, 61,187 poisoned patients (i.e. 32,107 patients in 2012 and 29,080 patients in 2013) were treated at the four hospitals. In these two years, 22,185 patients (36.3%) were treated at LHH, 22,160 patients (36.2%) at IRH, 10,897 patients (17.8%) at NAH and 5,945 patients (9.7%) at GRH. Cumulatively in all hospitals, the highest rate of admissions was due to drug poisoning (42,017, 68.7%), recreational substances overdose (7,302, 11.9%) and pesticide poisoning (5,217, 8.5%). Conclusion: Pharmaceutical products, substances of abuse and pesticides are the most common causes of poisoning-related admissions to referral Iranian poison treatment centers. Effective measures to reduce poisoning with these substances should be done.
- انتشار مقاله: 25-05-1394
- نویسندگان: Talat Ghane,Yasna Behmanesh,Anahita Alizadeh Ghamsari,Mina Amini,Fatemeh Siavashian,Atieh Yazdani-Rostam,Simin Mahdavi,Nader Haghi,Abdolkarim Pajoomand,Shahin Shadnia,Hossein Hassanian-Moghaddam,Mitra Rahimi,Nasim Zamani,Fardin Khazaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: Methadone,Iran,Poisoning,Death,incidence
- چکیده:
- چکیده انگلیسی: Background: In Iran, methadone has been used for methadone maintenance treatment (MMT) as well as analgesic treatment in pain clinics. Recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. The aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in Tehran, Iran.
Methods: This was a retrospective cross-sectional study over 2000 to 2010. Patients with a documented methadone poisoning who were admitted in Loghman Hakim Hospital Poison Center in Tehran, Iran were identified and included in the study. The data including patients’ age, gender, ingested dose, co-ingestants, intention of ingestion and outcome were extracted from the patients’ medical records.
Results: During the study period, 1426 cases of methadone poisoning were recorded, of which, 1041 cases (73%) were men. Thirty-six cases (2.5%) died. Mean age of the patients was 29.9 ± 17 years. In 476 cases, the intention of poisoning could not be determined, and in the remaining, the intention was misuse (n = 273, 28.7%), suicide (n = 254, 26.7%), accidental (n = 245, 25.8%) and abuse (n = 178, 18.8%). Mean of the ingested dose of methadone was 120.6 ± 306.8 mg. The incidence of acute methadone poisoning per one million population of Tehran was 0.43 in 2000 that rose to 37.62 in 2010.
Conclusion: The results indicate that methadone poisoning and deaths have increased in Tehran. MMT clinics should be strictly run according to the national guideline to prevent methadone poisoning. With regard to high frequency of poly-drug use in methadone poisoning, it seems important to warn health care providers against prescription of other drugs with methadone.- انتشار مقاله: 15-03-1393
- نویسندگان: Kambiz Soltaninejad,Hossein Hassanian-Moghaddam,Shahin Shadnia
- مشاهده