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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Membrane Science and Research
- نوع مقاله: Journal Article
- کلمات کلیدی: brackish water,Drinking water treatment,Dual-stage nanofiltration,Season variation
- چکیده:
- چکیده انگلیسی: Due to the impact of climate change, the process of salinity intrusion occurs frequently in coastal areas of Vietnam. The main objective of this study is therefore to try diff erent nanofi ltration (NF) processes (such as single-stage and dual-stage NF) to treat brackish water for residential areas in Thu Bon river basin, where the salinity varies signifi cant with seasons. Results have shown that during the rainy season, the salinity was less than 8.5‰, so the single stage NF worked perfectly. When season changes from rainy season to dry season, the river’s salinity increases up to 17.5‰, application of dual NF is most appropriate. This dual NF process not only guarantees the effl uent quality to meet National Technical Regulation, but also off ers reasonable energy cost and fi nally can prolong the membrane lifespan.
- انتشار مقاله: 15-04-1396
- نویسندگان: Ha Tran,HUYEN DANG,Hoa Quoc Nguyen,Tinh Thi Hong Nguyen
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: ALPHA,glucosidase Alpha,amylase Diabetes Ethyl acetate (EtOAc),extract In vivo model Smilax glabra Roxb
- چکیده:
- چکیده انگلیسی: Objective(s): This research was carried out to investigate the hypoglycemic activity of the ethyl acetate (EtOAc) extract from the roots of Smilax glabra Roxb, which strongly exhibit inhibitory activity against α-glucosidase and α-amylase on in vivo type 2 diabetic model.
Materials and Methods: Column chromatography combined with crystallization was used to isolate the active fraction and compounds. Chemical structures of the compounds were determined based on the analysis of the spectroscopic data and comparison with the literature data. The α-glucosidase inhibitory activity (AGI) and the α-amylase inhibitory activity (AAI) were determined quantitatively spectrophotometrically using p-nitrophenyl α-D-glucopyranoside and soluble starch as substrates, respectively. The hypoglycemic activity was examined by evaluating its effects on glucose and insulin levels, insulin resistance, and histopathology of the pancreatic islets and livers in diabetic induced mice administrated with nicotinamide-streptozotocin.
Results: The EtOAc extract and the bioactive compounds astilbin and 5-O-caffeoylshikimic acid in the extract were isolated and confirmed in structures, AGI, and AAI. The treatment at the doses of 500 and 1000 µg/kg of body weight reduced blood glucose levels down to the physiological level of the physical controls in the diabetic mice after two weeks (p <0.05). Moreover, the treatment improved insulin sensitivity. Histopathology analysis showed recovering effects in the size of the pancreatic islets and no damaging effects on the liver after treatment compared with the control group.
Conclusion: Our data suggest that the EtOAc extract possesses hypoglycemic activity and has an antidiabetic potential for therapeutic applications.- انتشار مقاله: 30-11-1398
- نویسندگان: Phuong Thi Mai Nguyen,Quang Van Ngo,Minh Thi Hong Nguyen,Lien Thi Quach,Stephen Pyne
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: ALPHA,glucosidase Alpha,amylase Diabetes Ethyl acetate (EtOAc),extract In vivo model Smilax glabra Roxb
- چکیده:
- چکیده انگلیسی: Objective(s): This research was carried out to investigate the hypoglycemic activity of the ethyl acetate (EtOAc) extract from the roots of Smilax glabra Roxb, which strongly exhibit inhibitory activity against α-glucosidase and α-amylase on in vivo type 2 diabetic model.
Materials and Methods: Column chromatography combined with crystallization was used to isolate the active fraction and compounds. Chemical structures of the compounds were determined based on the analysis of the spectroscopic data and comparison with the literature data. The α-glucosidase inhibitory activity (AGI) and the α-amylase inhibitory activity (AAI) were determined quantitatively spectrophotometrically using p-nitrophenyl α-D-glucopyranoside and soluble starch as substrates, respectively. The hypoglycemic activity was examined by evaluating its effects on glucose and insulin levels, insulin resistance, and histopathology of the pancreatic islets and livers in diabetic induced mice administrated with nicotinamide-streptozotocin.
Results: The EtOAc extract and the bioactive compounds astilbin and 5-O-caffeoylshikimic acid in the extract were isolated and confirmed in structures, AGI, and AAI. The treatment at the doses of 500 and 1000 µg/kg of body weight reduced blood glucose levels down to the physiological level of the physical controls in the diabetic mice after two weeks (p <0.05). Moreover, the treatment improved insulin sensitivity. Histopathology analysis showed recovering effects in the size of the pancreatic islets and no damaging effects on the liver after treatment compared with the control group.
Conclusion: Our data suggest that the EtOAc extract possesses hypoglycemic activity and has an antidiabetic potential for therapeutic applications.- انتشار مقاله: 30-11-1398
- نویسندگان: Phuong Thi Mai Nguyen,Quang Van Ngo,Minh Thi Hong Nguyen,Lien Thi Quach,Stephen Pyne
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: NSCLC,EGFR-TKI,sequential administration,Pemetrexed,PFS
- چکیده:
- چکیده انگلیسی: Objectives: The optimal combination of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
(TKIs) and chemotherapy has helped to improve therapeutic effects in non-small-cell lung cancer (NSCLC). This study
aimed to explore the progression free survival (PFS) of patients after sequential administration of TKI and pemetrexed
chemotherapy. Methods: This study retrospectively screened treatment-naive advanced NSCLC patients harbouring
EGFR mutations who were prescribed a TKI and salvaged with pemetrexed chemotherapy or vice versa. The total,
initial and salvage PFS were collected. Results: The total PFS including both the initial and salvage PFS was 18.0 mon
(95% CI: 14.1–21.9 mon), which was not influenced by the sequence of administration (TKI first: 18.0 mon, 95% CI:
15.8–20.2 mon, pemetrexed first: 16.1 mon, 95% CI: 9.1–23.1 mon, HR 0.92, P=0.748). A longer PFS was achieved
for TKI over chemotherapy in both the initial (10.6 and 5.9 mon, HR 2.62, P=0.001) and salvage therapy (12.0 and 6.0
mon, HR 1.29, P=0.001). TKI remained effective either before (10.6 mon) or after (12.0 mon) chemotherapy (HR 0.96,
P=0.853). The same trend was observed for chemotherapy (5.9 and 6.0 mon for initial and salvage therapy, respectively,
HR 0.82, P=0.417). Conclusions: The sequential administration of TKI and pemetrexed chemotherapy achieved a long
PFS and was a suitable treatment for advanced NSCLC.- انتشار مقاله: 12-01-1398
- نویسندگان: Chen Yue-Yun,Hong Ye,Fu Yang,Li Qing,Lin Pan-Pan,Ding Zhen-Yu
- مشاهده