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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Progress in Chemical and Biochemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastric,Antiulcerogenic,Lannea acida,Mechanism, Ethanol,Mucosal,Albino Rats
- چکیده:
- چکیده انگلیسی: Peptic ulcer disease is one of the most prevalent gastrointestinal disorders causing tremendous human suffering worldwide. The present study was designed to evaluate the antiulcerogenic activity of the methanol and solvent stem bark fractions (hexane, ethyl acetate and butanol) and elucidate their possible antiulcerogenic mechanisms. The antiulcerogenic mechanisms were investigated by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, Malondialdehyde (MDA) and involvement of KATp channel. Pretreatment with the methanol extract and solvent fractions produce significant reductions in ulcer index in a dose dependent manner. Ethylacetate fraction (EtyAc) showed the highest antiulcer activity. Elevated MDA and decreased levels of SOD, GSH, CAT, Vitamin A, C and E observed in ulcer control groups were significantly decreased and increased respectively in the EtyAc fraction treated groups. Antiulcer activity of the EtyAc fraction was blocked upon coadministration with glibenclamide; a KATp channel blocker. The stem bark extract of Lannea acida possess antiulcerogenic activity and the mechanisms seems to involve antioxidant activity and KATp channel opening.
- انتشار مقاله: 21-08-1397
- نویسندگان: Onoshe Solomon,Wasagu Rabiu Saidu Umar,Hassan Sanusi Wara,Abubakar Sadiq Yakubu,Madusolumou Michael Azubuike,Mbahi Asugu Mary,Hitler Louis
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Medicinal and Chemical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Charantin,N-isopropyl acrylamide,PNIPAM-based hydrogel,Swelling kinetics
- چکیده:
- چکیده انگلیسی: The swelling kinetics of charantin from poly (N-isopropyl acrylamide), PNIPAM–based hydrogel, is accomplished through direct weighing, before soaking the gel in fluid/drug solution at controlled temperatures inside a temperature-controlled water bath. The investigation was carried out for application as anti-diabetic drug delivery system. Charantin was extracted from bitter melon fruit and leaf under a controlled pH of 4.5. The preparation of PNIPAM was done by varying the acrylamide between (3-12)% and show increase in the lower critical solution temperature (LCST) from 32- 43℃ which indicates a direct relationship in distilled water. The effect of changing solution from distilled water, insulin, and charantin solution, shows that the higher the polarity of the solution, the lower the LCST of the hydrogel. Charantin loaded on hydrogels N1, N2, N3, and N4 were found to be (42.51, 44.57, 43.55 and 44.61)μg/mL, respectively, when soaked in charantin solution of 52.61 μg/mL. Characterization of the hydrogels using Fourier transformed infrared (FTIR) spectroscopy shows that there is physical interaction between the hydrogel matrix and the charantin molecules. The diffusivity of the hydrogels ranged from 1.48 x 10-10 to 5.08 x 10-8 M2/s and their release exponents were ≥ 0.5 indicative of non-Fickian difusional release.
- انتشار مقاله: 11-07-1397
- نویسندگان: Danjatau W. Dogo,Hitler Louis,Nkafamiya I. Iliya,Akakuru U. Ozioma,Adeleye T. Aderemi,Barminas Stware
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Medicinal and Chemical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: plants,Pharmacology,Structure,Alkaloids
- چکیده:
- چکیده انگلیسی: The importance of natural products in the pharmaceutical industry cannot be abated because it plays a vital role in the prevention and treatments of diseases such as cancer, malaria, pile etc. These natural products e.g. alkaloid, flavonoid, phenol, saponin, and tannin are bioactive compounds in a plant which are essential in plant metabolic activities. All of these including alkaloids has been tested for their huge medicinal properties hence, serves as an alternative medicine. Although, through the modern-day technologies, these bioactive compounds are separated from the plants and synthesized into capsules and tablets for easy administration, usage, and storage. The manner of poisoning with plants can be due to unintentional ingestion, affordability, and availability, excess ingestion, improper methods of extraction and purification of plant materials. In some cases, the resultant effect(s) of these poisoning may cause serious illness, injury or even death. Thus, this review gives an overview of the pharmacological importance of named alkaloids, toxicology and methods of extraction and purification of alkaloids in the plant. Furthermore, this review will provide information to researchers to further investigate the medicinal potentials of these alkaloids, help in the development of new drugs for the treatment of various diseases, creates awareness on the side-effects of excess or abuse of medicinal plants and finally encourages rational use of natural resources for sustainability.
- انتشار مقاله: 05-06-1397
- نویسندگان: Hamzat T. Adejoke,Hitler Louis,Oluwatobi O. Amusan,Gloria Apebende
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Medicinal and Chemical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Mechanism,Synthesis,Curcumin,Nanotechnology,Anticancer
- چکیده:
- چکیده انگلیسی: Curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. This medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. In order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. Here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed.
- انتشار مقاله: 04-06-1397
- نویسندگان: Grace Kwata Fidelis,Hitler Louis,Timothy Fidelis Tizhe,Solomon Onoshe
- مشاهده
- جایگاه : پژوهشی
- مجله: Chemical Methodologies
- نوع مقاله: Journal Article
- کلمات کلیدی: Power Conversion Efficiency (PCE%),Bulk Heterojunction (BHJ),Interfacial Layer,Electron Transport Layer (ETL),Hole Transport Layer (HTL),Indium tin oxide (ITO)
- چکیده:
- چکیده انگلیسی: The global quest for reliable sources of energy has led to the development of Organic solar cells (OSCs)/ Organic photovoltaics (OPVs). Over the past few years, they have shown great potentials and use as low cost devices for conversion of solar energy. OSCs are designed from different interface layers from different materials which form a major determinant for their energy conversion efficiency. The recent development in the modifications in design and engineering of these interface materials have shown increased power conversion efficiency (PCE%) of Organic photovoltaics. Interface materials are conductors, semiconductors or non-conductors which provide selective contact for carriers, determine polarity and acts as protective layers. This review discusses different materials which are used as interface materials as well as their structure and engineering.
- انتشار مقاله: 05-07-1397
- نویسندگان: Oluwatobi O. Amusan,Hitler Louis,Saud-uz- Zafar,Adejoke T. Hamzat,Dass M. Peter
- مشاهده
- جایگاه : پژوهشی
- مجله: Chemical Methodologies
- نوع مقاله: Journal Article
- کلمات کلیدی: Synthesis,MOFs,Methodologies,applications
- چکیده:
- چکیده انگلیسی: The pursuit of rapid development in the area of catalysis, solar energy, environmental remediation, wastewater treatment and other aspects of ecological and sustainable chemistry has prompted substantial research by material chemists, physicists, academics and other scientists for the development of porous material. A lot of energy had been invested in this course by scientist, research organizations and public sector agencies from antiquity, but the resulting solution has been somewhat undesirable until two decades ago when Metal-Organic Frameworks (MOFs) appears to offer a glimpse of solution to those challenging issues. The adaptability, flexibility, uniqueness and usability of the metal-organic frameworks material, and its suitability to every facet of scientific and technological advancement has since triggered an incredible upsurge in studies aimed at uncovering more of the inherent influential properties of the materials, and its improvement for the betterment of material science and research world. This review is aimed at investigating some of the recent advancements/ breakthrough in metal-organic frameworks, synthetic methodologies and impending applications.
- انتشار مقاله: 15-04-1397
- نویسندگان: Abdulraheem Anumah,Hitler Louis,Saud-uz- Zafar,Adejoke T. Hamzat,Oluwatobi O. Amusan,Amos I. Pigweh,Ozioma U. Akakuru,Aderemi T. Adeleye,Thomas O. Magu
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Lignocellulosic biomass,Ionic liquids (ILs),Biorefinery,Biofuels
- چکیده:
- چکیده انگلیسی: Lignocellulosic biomass contains polymers of cellulose, hemicellulose, and lignin, bound together in a complex structure. Many physicochemical structural and compositional factors hinder the hydrolysis of cellulose present in biomass to sugars and other organic compounds that can later be converted to fuels. These factors hindering access to sugars contained in lignocelluloses are summed up as “recalcitrance”. As a result, pretreatment is required to allow liberal access to the full contents of lignocellulosic biomass. Production of value added co-products along with biofuels through integrated biorefinery processes create the need for selectivity during pretreatment. Pretreatment is an important tool for biomass-to-biofuels conversion processes and is the subject of this review article. The major target of pretreatment is to make the cellulose accessible to hydrolysis for conversion to fuels. Various pretreatment techniques change the physical and chemical structure of the lignocellulosic biomass and enhance the degree of hydrolysis. During the past few years a large number of pretreatment methods have been developed, including alkali treatment, ammonia explosion, and others. Many methods have been shown to result in high sugar yields, for lignocellulosic biomasses such as woods, grasses, corn, rice straw, etc. In this review, we discuss the ionic liquids (ILs) pretreatment method in biorefinery and the recent literature that has reported on the use of these so called green solvents for pretreatment of various lignocellulosic biomasses, ionic liquids have recently become very popular solvents for the dissolution of biomass due to their unique features as compared to conventional solvents.
- انتشار مقاله: 07-06-1397
- نویسندگان: Aderemi T. Adeleye,Hitler Louis,Hamzat A. Temitope,Monday Philip,Pigweh I. Amos,Thomas O. Magu,Akakuru U. Ozioma,Oluwatobi O. Amusan
- مشاهده