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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognostic factor,metastatic urothelial carcinoma,second-line chemotherapy,sarcopenia,skeletal mass index
- چکیده:
- چکیده انگلیسی: Background: Patients with metastatic urothelial carcinoma (mUC) have an uncertain prognosis. The aim of the current study was to evaluate the prognostic potential of a skeletal muscle mass reduction index measured by computed tomography (CT) for mUC patients undergoing second-line gemcitabine and docetaxel (GD) chemotherapy. Methods: We retrospectively reviewed 44 patients with mUC who received second-line GD chemotherapy between 2006 and 2015 in our hospital. Skeletal muscle area (SMA) at the third lumbar vertebra was measured using CT images obtained from medical records, and a skeletal muscle index (SMI) was calculated for each patient as: SMI = SMA / height2. Changes in SMI across timepoints (SMI inclination) were calculated as: SMI inclination = [( SMI/SMI)/duration of the interval between imaging visits]. Patients were then divided into two groups: a “steep” group (SMI inclination < -0.01) and a “gentle” group (SMI inclination ≥ -0.01). Kaplan-Meier curves and multivariate Cox proportional hazards regression models were used to evaluate the relationship between SMI inclination and overall survival (OS). Results: There were no differences in patient characteristics between the two groups with respect to median age, gender, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), disease control rate or first-line treatment regimen. OS from the start of second-line GD therapy group was significantly shorter in the “steep” group relative to the “gentle” group. The multivariate analysis revealed that “steep” SMI inclination and presence of anemia were strong predictors of poor prognosis. Conclusion: Higher values of SMI inclination, indicating a faster rate of skeletal muscle mass reduction, may serve as a useful predictive marker for OS in mUC patients undergoing second-line GD chemotherapy.
- انتشار مقاله: 18-02-1398
- نویسندگان: Takashi Nagai,Taku Naiki,Keitaro Iida,Satoshi Nozaki,Toshiki Etani,Yosuke Sugiyama,Ryosuke Ando,Takahiro Yanase,Ryosuke Chaya,Yoshinobu Moritoki,Daichi Kobayashi,Hidetoshi Akita,Takehiko Okamura,Takahiro Yasui
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytology,fish,Urinary bladder carcinoma,cystoscopy
- چکیده:
- چکیده انگلیسی: Objective: UroVysion (Abbott Molecular, Inc., Illinois, USA) is based on multicolor fluorescence in situ hybridization
(FISH). It has been used successfully in the USA following its Food and Drug Administration approval in 2001. However,
the technology was not approved for use in Japan until 2017. Cystoscopy and urine cytology are the most frequently
used examinations to detect bladder cancer in Japan, and there are only a few reports regarding the performance of
UroVysion. Therefore, the aim of this study is to examine the diagnostic accuracy of UroVysion FISH in Japanese
patients whose tumors are detected by cystoscopy before transurethral resection of bladder tumor (TURBT). Methods:
From April 2018 to July 2018, a total of 40 patients who were diagnosed as having bladder tumors by cystoscopy, and
therefore underwent TURBT were registered in this study. One day before TURBT, urine cytology and UroVysion
FISH were used in order to compare the accuracy with which they could detect bladder carcinoma, as confirmed by
pathological results of TURBT. Results: The pathological results of TURBT showed urothelial carcinoma in 33 cases.
Urine cytology showed positive results for 0 cases (0%), suspicious results for 10 cases (30.3%), and negative results
for 23 cases (69.7%). On the other hand, UroVysion FISH indicated 9 positive cases (27.3%) and 24 negative cases
(72.7%). There were 19 cases of urothelial carcinoma (57.6%) that were not detected by either method. Conclusion:
We conclude that UroVysion FISH alone is insufficient to detect bladder cancer and that cystoscopy is essential for the
optimum detection or follow up of bladder cancer cases in our hospital.- انتشار مقاله: 10-11-1397
- نویسندگان: Takashi Nagai,Takehiko Okamura,Takahiro Yanase,Ryosuke Chaya,Yoshinobu Moritoki,Daichi Kobayashi,Hidetoshi Akita,Takahiro Yasui
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cystectomy,nephroureterectomy,Umbilical approach,reduced port surgery
- چکیده:
- چکیده انگلیسی: Objective: In recent years, although reduced port surgeries (RPS) have been reported for many urological diseases,
there have been no reports regarding simultaneous laparoscopic cystectomy and unilateral or bilateral nephroureterectomy
with umbilical RPS. Therefore, the aim of this study was to evaluate outcomes and complications of simultaneous
laparoscopic cystectomy and unilateral or bilateral nephroureterectomy with umbilical RPS. Methods: We performed
a preliminary case series of 4 patients with synchronous upper urinary tract (UUT) tumor and invasive bladder cancer
who underwent simultaneous laparoscopic cystectomy and unilateral or bilateral nephroureterectomy with umbilical RPS
between 2014 and 2017 at our hospital. Demographic data, pathologic features, the surgical technique, and outcomes
were retrospectively analyzed. Result: All 4 patients were men whose median age was 79 years (range 65-85 years) and
median body mass index was 24.2 kg/m2 (range 21.5-27.3 kg/m2). The laparoscopic approach was technically successful
in all 4 patients without the need for open conversion. The median total operative time was 434 minutes (range 372-481
minutes). The median estimated blood loss was 773 ml (range 153-923 ml), median interval to resuming oral intake
was 2 days (range 1-7 days), and median hospital stay was 16 days (range 13-20 days). Conclusion: The reduced port
approach is technically feasible in terms of many outcome measures, with significant cosmetic advantages. This method
can be performed safely and recommended as a viable option for patients with concomitant UUT and bladder cancer.- انتشار مقاله: 16-01-1397
- نویسندگان: Yutaro Tanaka,Takehiko Okamura,Ryosuke Chaya,Takashi Nagai,Daichi Kobayashi,Takahiro Kobayashi,Hidetoshi Akita,Takahiro Yasui
- مشاهده