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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Report of Health Care- (لغو رتبه)
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Polymorphism,Gestational diabetes
- چکیده:
- چکیده انگلیسی: Introduction: Gestational diabetes mellitus is a multi-factor disease. Several genes are shown to be associated with diabetes mellitus. Among them, IRS-1 gene is located on chromosome No.2 which is an endogen substrate for insulin receptor. IRS-1 gene has an important role in insulin pathway signaling. Aim of this study was to review the association of Ala513Pro and Gly972Arg IRS-1 gene polymorphism with gestational diabetes mellitus in south of Iran. Methods: 200 subjects with gestational diabetes mellitus and 200 healthy subjects as control group were enrolled in the study. DNA was extracted from their blood and polymorphism of G, C and T allele were studied. It was aimed to investigate whether genotype is associated with clinical and biochemical variables such as family history, fasting blood sugar, blood lipid and body mass index. Independent sample t- test, chi- square test, logistic regression and Hardy- Weinberg equilibrium tests were used to analyze data (p≤0.05). Results: The finding from the Polymorphism Gly972Arg study show that individuals with CC, CT genotypes were associated with an increased risk of the disease (%95CI: 0.02-0.44, OR=0.1, P<0.001), (%95CI:2-58.43, OR=9.2, P<0.01). There was no allele and genotypic variation in Polymorphism Ala513Pro Polymorphism. Conclusion: Based on the obtained results, Ala 513Pro polymorphism of the IRS-1 gene was not correlated, but Gly 972 Arg polymorphism related with gestational diabetes mellitus in population of south Iran.
- انتشار مقاله: 20-03-1396
- نویسندگان: Heydar Aghababa,Sana Edalat Panah,Bahareh Jokar
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Crocus sativus,Inflammation,Asthma,Sensitization,WBC,Ovalbumin
- چکیده:
- چکیده انگلیسی: Objective: Inflammation is one of the major components of asthma. Our aim was to evaluate the effects of C. sativus extract on total and differential white blood cells (WBC) count in lung lavage fluid (LLF) of ovalbumin-sensitized rats.
Materials and Methods: Forty rats were divided into five groups (n = 8 for each group) as control (C), sensitized with injection and inhalation of ovalbumin (OA) alone (S), and three groups of sensitized and treated with different doses of C. sativus extract (S+50EX, S+100EX, and S+200EX groups). Total and differential WBC counts of LLF were evaluated in control, sensitized, and treated sensitized groups.
Results: Total WBC count, neutrophil, and eosinophil percentage in LLF were increased in sensitized animals compared with the control group (p<0.001). Treatment of sensitized animals with all doses of the extract significantly reduced WBC number and the percentage of neutrophil and eosinophil compared with the sensitized animals (p<0.01–0.001).
Conclusion: According to these results, the extract of C. sativus could be effective on alleviating lung inflammatory cells specially eosinophils in lung lavage of sensitized animals which may indicate a preventive effect of this plant on lung inflammation in asthma.- انتشار مقاله: 25-02-1392
- نویسندگان: Maryam Mahmoudabady,Ali Neamati,Somayyeh Vosooghi,Heydar Aghababa
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Crocus sativus,Inflammation,Asthma,Sensitization,WBC
- چکیده:
- چکیده انگلیسی: Objective: Asthma is a chronic inflammatory disease of the respiratory airways distinguished by edema and infiltration of inflammatory immune cells. To test our hypothesis about the anti-inflammatory effect of saffron, we examined effects of Crocus sativus (C. sativus) extract as a prophylactic anti-inflammatory agent in sensitized rats.
Materials and Methods: To induce experimental asthma, rats were sensitized with injection and inhalation of ovalbumin (OA). Forty male Wistar rats were divided into 5 groups (n=8 for each): control, sensitized (asthma), and sensitized and pretreated with three different concentrations of extract, 50, 100, and 200 mg/kg, 2 times a week (group asthma+50EX, group asthma+100EX, and group asthma+200EX). After 32 days, total white blood cells (WBC) counts, red blood cells (RBC), and platelet counts in blood were examined.
Results: Total WBC number and eosinophil and neutrophil percentage in blood were increased, but lymphocyte decreased in sensitized animals compared with those of control group (pConclusion: Our findings indicated that the extract of C. sativus could be useful to prevent asthma as an anti-inflammatory treatment.- انتشار مقاله: 18-11-1391
- نویسندگان: Somayyeh Vosooghi,Maryam Mahmoudabady,Ali Neamati,Heydar Aghababa
- مشاهده