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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: anxiety,Aromatherapy,depression,lavender,hemodialysis
- چکیده:
- چکیده انگلیسی: Background: Depression, anxiety and stress are common among hemodialysis patients affecting their mental health and quality of life, leading to multiple dysfunctions. Anti-anxiety effects of aromatherapy, as one of the domains of complementary medicine, have been investigated in several studies.
Aim: Investigation of the effect of aromatherapy with lavender essential oil on depression, anxiety and stress rates in hemodialysis patients.
Methods: This study was a randomized controlled clinical trial performed on 60 patients undergoing hemodialysis in Tehran, Iran in 2014. The patients were randomly divided into intervention and control groups. To measure the rate of depression, anxiety and stress, the Depression Anxiety Stress Scales-21 was used. In the intervention group, the patients were asked to inhale the lavender essential oil smeared on a piece of cloth (three drops of oil) for one hour during the hemodialysis procedure. After 4 weeks, the rates of depression, anxiety and stress were re-measured. Data analysis was performed by SPSS software version 14 using chi-square, Wilcoxon and Mann-Whitney U statistical tests.
Results: In this study, 33(60%) of the participants were male, and 53(96.4%) were married. After the intervention, the scores of depression (P<0.001) and stress (P<0.04) significantly decreased in the intervention group in comparison with control group; but the reduction in the anxiety score was not statistically significant.
Conclusion: Aromatherapy with lavender essential oil might reduce depression and stress among hemodialysis patients. Therefore, this method can be used as a complementary method with less complication to improve the quality of life of these patients.- انتشار مقاله: 29-10-1393
- نویسندگان: Ali Tayebi,Alireza Kasra Dehkordi,Abbas Ebadi,Hedayat Sahraei,Behzad Einollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Amygdala,coping strategies,Stress,Cortisol,Epinephrine,Rhesus macaque
- چکیده:
- چکیده انگلیسی: Objective(s): In the present study the effect of stress on monkeys that had learned to retrieve food from a five-chamber receptacle, as well as the relationship between their behavior and the serum cortisol and epinephrine levels and relative size of the amygdala was evaluated.
Materials and Methods: Six male rhesus monkeys were individually given access to the food reward orderly. They could easily retrieve the rewards from all chambers except for the chamber 4, which a brief, mild electric shock (3 V) was delivered to them upon touching the chamber’s interior. The coping behaviors were video-recorded and analyzed offline. Baseline serum cortisol and epinephrine levels were measured before the experiments using monkey enzyme-linked immunosorbent assay kit. One week after the behavioral experiment, the monkeys’ brains were scanned using magnetic resonance imaging under general anesthesia. The cross-sectional area of the left amygdala in sagittal plane relative to the area of the whole brain in the same slice was evaluated by the planimetric method using ImageJ software.
Results: Exposure to the distressing condition caused different behavioral responses. Monkeys with higher baseline levels of serum cortisol and epinephrine and larger amygdala behaved more violently in the face of stress, indicating adopting emotion-focused stress-coping strategies. Conversely, those with low plasma epinephrine, moderate cortisol, and smaller amygdala showed perseverative behavior, indicating a problem-focused coping style.
Conclusion: In dealing with the same stress, different responses might be observed from nonhuman primates according to their cortisol and epinephrine levels as well as their amygdala dimensions.- انتشار مقاله: 14-05-1396
- نویسندگان: Elaheh Tekieh,Esmail Riahi,Masoomeh Kazemi,Hedayat Sahraei,Hassan Tavakoli,Hamed Aliyary,Mostafa Hajinasrollah,Maryam Salehi,Gholamhossein Meftahi,Mehdi Saberi
- مشاهده
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: anxiety,Aromatherapy,depression,lavender,hemodialysis
- چکیده:
- چکیده انگلیسی: Background: Depression, anxiety and stress are common among hemodialysis patients affecting their mental health and quality of life, leading to multiple dysfunctions. Anti-anxiety effects of aromatherapy, as one of the domains of complementary medicine, have been investigated in several studies.
Aim: Investigation of the effect of aromatherapy with lavender essential oil on depression, anxiety and stress rates in hemodialysis patients.
Methods: This study was a randomized controlled clinical trial performed on 60 patients undergoing hemodialysis in Tehran, Iran in 2014. The patients were randomly divided into intervention and control groups. To measure the rate of depression, anxiety and stress, the Depression Anxiety Stress Scales-21 was used. In the intervention group, the patients were asked to inhale the lavender essential oil smeared on a piece of cloth (three drops of oil) for one hour during the hemodialysis procedure. After 4 weeks, the rates of depression, anxiety and stress were re-measured. Data analysis was performed by SPSS software version 14 using chi-square, Wilcoxon and Mann-Whitney U statistical tests.
Results: In this study, 33(60%) of the participants were male, and 53(96.4%) were married. After the intervention, the scores of depression (P<0.001) and stress (P<0.04) significantly decreased in the intervention group in comparison with control group; but the reduction in the anxiety score was not statistically significant.
Conclusion: Aromatherapy with lavender essential oil might reduce depression and stress among hemodialysis patients. Therefore, this method can be used as a complementary method with less complication to improve the quality of life of these patients.- انتشار مقاله: 29-10-1393
- نویسندگان: Ali Tayebi,Alireza Kasra Dehkordi,Abbas Ebadi,Hedayat Sahraei,Behzad Einollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Morphine,Baclofen,Rats,Amygdala
- چکیده:
- چکیده انگلیسی: Background: The amygdala is one of the nerve centers involved in drug reward. It is suggested that the central nucleus of the amygdala (CeA) is involved in morphine dependency. The CeA gamma-aminobutyric acid-ergic (GABAergic) system is a mediator of morphine rewarding effects. In this research, the effects of stimulation or inhibition of CeA GABA type B (GABAB) receptors on sensitization acquisition to morphine-induced reward was evaluated in Wistar female rats using conditioned place preferential (CPP) method.Methods: Wistar female rats provided by Shahid Beheshti University, Tehran, Iran, were allocated into 17 groups including 7 groups of determining morphine dose-response, 2 groups of sensitivity and control, and 8 groups of different doses of agonists and antagonists in the acquisition stage (n = 7 in each group). Various quantities of morphine (0.5, 1, 2.5, 5, 7.5, 10 mg/kg of animal weight) were used to determine the effective and neutral doses of morphine. After 5 days from the start of the surgery, sensitization was induced. After the end of the sensitization period, CPP was conducted. Baclofen and CGP35348, as an agonist and antagonist of GABAB respectively, with the dose of 1.5, 6 and 12 μg/rat were inserted to the CeA, ten minutes before taking morphine.Findings: Administration of baclofen had no significant effect on the acquisition of morphine sensitization. In contrast, injection of CGP35348 reduced the sensitivity to morphine.Conclusion: GABA receptors can be effective in reducing morphine tendency by specific receptors, so these sites can be important therapeutic targets in counteracting the effects of drug abuse.
- انتشار مقاله: 30-06-1396
- نویسندگان: Firoozeh Alavian,Saeedeh Ghiasvand,Hedayat Sahraei,Maryam Rafiei-Rad
- مشاهده