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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Bread,Functional food,Enrichment ,Licorice,Islamic fasting
- چکیده:
- چکیده انگلیسی: Introduction: Thirst is one of the main complaints during Islamic fasting. As bread is the staple food among most Muslims, evaluating its impact on thirst is important. In this study, we investigated the effect of licorice-enriched barley bread compared to barley bread and white wheat bread. Methods: This clinical trial was performed on three consecutive days during Itikaf ceremony. Data were garnered by using a checklist including items on demographic data, weight, height, waist circumference, blood pressure, and pulse rate. Blood pressure and pulse rate measurements were repeated at the end of the study. The participants were divided into three groups receiving functional barley bread enriched with licorice, barley bread, and white wheat bread. The thirst sensation was assessed by Fan visual analogue scale. Also, 24-hour dietary recall was obtained on all the three days. Results: Overall, 273 people participated in this study. Thirst sensation in the functional barley bread was lower than that in the wheat bread and barley bread groups, but there were no significant differences between wheat and barley bread groups in this regard. During the fasting period, the greatest increase in thirst was observed during the first five hours of fasting in all the three groups, which was significantly lower in the functional barley bread group than the wheat and barley bread groups; however, there was no significant difference between wheat and barley bread groups in this respect. Finally, similar results were attained following fluid intake adjustment.Conclusion: This study showed that licorice enrichment of barley bread might alleviate thirst sensation among fasting individuals.
- انتشار مقاله: 02-10-1396
- نویسندگان: M.R. Amiryousefi,Davoud Soleimani,Sara Movahed,Maryam Khosravi,Seyyed Mojtaba Mousavi Bazzaz,Hassan Rakhshandeh,Maryam Golzar,Naseh Pahlevani,Effat Saghi,Safieh Firouzi,Zahra Ghaemi,Fatemeh Pourebrahim,Mahsa Malek Ahmadi,Kazem Eslami,Reyhaneh Zadehahmad,Mohsen Nematy
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Women,ginger,massage,Labor pain
- چکیده:
- چکیده انگلیسی: Background & aim: The negative effect of labor pain on the tendency of mothers to choose vaginal delivery demands identifying effective and safe methods to reduce pain. Regarding the analgesic effects of ginger, the present study aimed to determine the effect of back massage with and without ginger oil on the pain intensityin the active phase of labor in primiparous women.
Methods: This randomized clinical trial was conducted on 90 primiparous women in Umm al-Banin Hospital, Mashhad, Iran (2017). The subjects were selected using convenient sampling and randomly assigned into three groups, namely massage with ginger oil, massage with placebo (i.e., paraffin), and control group. The intervention and placebo groups received 15-minutes back massage in the active phase of labor. The pain intensity was measured in three groups before and after each dilation. The data were collected using questionnaires for demographic and obstetric data as well as Visual Analog Scale for pain measurement. The obtained data were analyzed in SPSS software (Version 16) through Kruskal-Wallis and the Chi-square tests.
Results: The mean values of pain intensity after three evaluations were obtained as 4.1±2.29, 6.8±1.73, and 7.6±1.43 in ginger, placebo, and control groups, respectively. The results showed that the ginger group reported the lowest level of pain during the active phase of labor (P<0.001).
Conclusion: Back Massage with ginger oil not only has effect on pain relief but also was completely safe in order to be administered to mothers during their first experience of childbirth.- انتشار مقاله: 05-10-1397
- نویسندگان: Marzyeh Azizi,Sedigheh Yousefzadeh,Hassan Rakhshandeh,Hamid Reza Behnam,Masoumeh Mirteymouri
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Breastfeeding,Purslane,Nipple soreness,Lanolin
- چکیده:
- چکیده انگلیسی: Background & aim: Despite the global efforts to promote breastfeeding, women report some problems leading to stop breastfeeding in the early postpartum. Nipple soreness is considered as one of the main causes of early breastfeeding discontinuation. Treatment of this problem could keep breastfeeding for a prolonged period of time. Therefore, the present study aimed to investigate the effect of nipple pain treatment with lanolin and purslane cream on frequency and duration of breastfeeding.
Methods: This double-blinded, randomized clinical trial was conducted on 86 breastfeeding women with nipple soreness who attended healthcare clinics in Mashhad, Iran, in 2016. The participants were randomly allocated to two equally sized group (43 in each), receiving purslane cream and lanolin for eight days. The correct method of breastfeeding and using the cream were trained to both groups. The nipple pain score was measured before intervention and on the third and eighth days post-intervention using a numeric pain rating scale. The subjects were also trained to record the duration and frequency of breastfeeding during the study period. Data were analyzed by SPSS version 22 using t-test, Fisher's exact test, Chi-square, and Wilcoxon tests.
Results: Two study groups were identical in terms of the pain intensity before intervention. There was a significant difference concerning the pain intensity between the two groups on days 3 and 8. The pain intensity in the purslane cream group was significantly lower than the lanolin group (p <0.001). The frequency of breastfeeding in the purslane group after the fourth day was significantly higher than the lanolin group (P=0.017). However, there was no significant difference between the two groups regarding the duration of breastfeeding (P=0.423).
Conclusion: Improving nipple pain by purslane cream can promote the frequency of breastfeeding. As a result, it can be considered as an effective agent in treatment of nipple soreness in nursing mothers.- انتشار مقاله: 16-04-1396
- نویسندگان: Azin Niazi,Sedigheh Yousefzadeh,Hassan Rakhshandeh,Habibollah Esmaeily
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Dyspareunia,Menopause,Date palm pollen,Vaginal lubrication
- چکیده:
- چکیده انگلیسی: Background & aim: Estrogen and androgen deficiency in menopause leads to poor vulvovaginal blood flow, vaginal dryness, and dyspareunia which can reduce the quality of life among the women. In this regard, this study investigated the impact of date palm pollen capsules on vaginal lubrication and dyspareunia in postmenopausal women.
Methods: The present triple-blinded, placebo-controlled clinical trial was conducted on 60 menopausal women aged 40-65 years, who referred to the health centers affiliated to the Mashhad University of Medical Sciences, Mashhad, Iran, in 2015. The subjects were randomly assigned to two groups of intervention and placebo (n=30), receiving date palm pollen and placebo capsules (350 mg, daily), respectively, for 35 days. The data were collected at two stages (at the baseline and after treatment) using the Female Sexual Function Index, a part of which evaluated vaginal lubrication and dyspareunia. Data analysis was performed in SPSS (version 16) using the independent t-test, Mann-Whitney U test, and ANCOVA.
Results: There was a significant difference between the two groups after the intervention in terms of vaginal lubrication (P<0.001) and dyspareunia (P=0.048). The results of the ANCOVA revealed a significant difference between the intervention and placebo groups regarding the two investigated domains of sexual function by controlling the effect of the confounding factors.
Conclusion: As the findings indicated, the administration of date palm
pollen could improve vaginal lubrication and reduce dyspareunia in the postmenopausal women.- انتشار مقاله: 03-02-1396
- نویسندگان: Somayeh Sadeghi Goghari,Sedigheh Yousefzadeh,Hassan Rakhshandeh,Salameh Dadghar,Seyed Reza Mazloom
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Doxorubicin,Capparis spinosa,H9C2 cells
- چکیده:
- چکیده انگلیسی: Objective: Doxorubicin (DOX) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. Recent studies showed that Capparis spinosa (C. spinose)exhibits potent antioxidant activity. So, in this study, we explored the protective effect of hydro-alcoholic extract of C. spinosa against DOX-induced cytotoxicity in H9c2 cells.
Materials and Methods: Cell viability was quantified by MTT assay. Apoptotic cells were determined using flow cytometry (sub-G1 peak) evaluation of DNA fragmentation following PI staining. Cells were cultured with 5 μM DOX for 24 hr to induce cell damage. H9c2 cells were pretreated with different concentrations (6-200 μg/ml) of C. spinosa extract for 4 hr before DOX treatment in all trials.
Results: Pretreatment with 25, 50, 100 and 200 µg/ml of C. spinosa could increase the viability of H9C2 cells to 72.63 ± 2.8% (p< 0.05), 77.37 ± 1.8% (p< 0.05), 83.56 ± 2.6% (p< 0.001) and 90.9 ± 0.5% (p< 0.001) of control, respectively. Also, C. spinosa decreased apoptotic induction significantly, at the doses of 50 µg/ml (p<0.05), 100 µg/ml (p<0.01) and 200 µg/ml (p<0.001)
Conclusion: Our results showed that C. spinosa could exert cardioprotective effects against DOX-induced toxicity that might be mediated via its antioxidant activity.- انتشار مقاله: 28-02-1394
- نویسندگان: Seyed Hadi Mousavi,Azar Hosseini,Elham Bakhtiari,Hassan Rakhshandeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Pregnancy,Nigella sativa,Stillbirth
- چکیده:
- چکیده انگلیسی:
Objective: The possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of Nigella sativa (N. sativa), which is already in clinical use for vaginal fungal infection.
Materials and Methods: The pregnant rats were treated intravaginal with physiological saline (vehicle) or phytovagex pessary in the first half of their pregnancy (days 1 to 10 of gestation). Duration of pregnancy and health parameters of the newborns were recorded after parturition. Also, cytotoxicity of N. sativa hydroalcoholic extract was tested against ovary Cho cells.
Results: The phytovagex had no significant effect on the duration of pregnancy, number of newborns, weight of neonates, and percent of stillbirth. No deformity or general behavioral abnormality was observed in neonates monitored for 30 days after birth. N. sativa extract had no significant effect on the viability of ovary cells at the concentrations of 12.5-200 µg/mL.
Conclusion: Results of this animal study showed that phytovagex has no overall effect on the duration of pregnancy and health parameters of the newborns. Also, its active agent, N. sativa, does not induce any cytotoxic effect on ovary cells.- انتشار مقاله: 26-12-1393
- نویسندگان: Reza Salarinia,Hassan Rakhshandeh,Davood Oliaee,Sima Gul Sima Gul Ghasemi,Ahmad Ghorbani
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Weight loss,Appetite,Artemisia absinthium,Orexigenic effect
- چکیده:
- چکیده انگلیسی: Objectives: weight loss as a consecution of losing appetite in post-operative patients and those suffering from HIV, cancer, cachexia and inflammatory diseases are the main inducements of morbidity and mortality. There is an increasing demand for more efficacious and endurable appetite stimulating treatment for patients with cachexia. Health economics is influenced by the malnutrition which was accounted for 5% of Iranian populations in 2011. Artemisia absinthium is known as an orexigenic herb in Iranian traditional medicine. Little evidence is available about its orexigenic effect and mechanism. So, the present study evaluated the possible effect on appetite of hydroalcoholic extract of Artemisia absinthium.
Materials and Methods: Thirty male Wistar rats were randomly divided into five groups. Vehicle group received 0.5 ml water per day, control group did not receive anything and other 3 groups received 50, 100 and 150 mg/kg of Artemisia absinthium for 7 days respectively. The daily amount of the food eaten by each rat was measured for 10 consecutive days. The amount of energy intake for each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Results: The results suggest that there was no significant (p>0.05) differences in energy received before and during intervention between three case groups compared with the control group. The energy intake in 1-2 hours after extract injection in all groups, and energy intake after 24 hours interval in third case group (receiving 150 mg/kg extract) is higher compared to other intervals, but it is not significant (p>0.05). So, it can be stated that there was no significant differences between energy intake of 3 case groups and control group.
Conclusion: Artemisia absinthium had no positive and dose-related effects on appetite of rats. Future studies are needed to evaluate the orexigenic effect of this plant.- انتشار مقاله: 12-10-1392
- نویسندگان: Sara Baghban Taraghdari,Mohsen Nematy,Mohsen Mazidi,Maryam Kamgar,Mohammad Soukhtanloo,Mahmoud Hosseini,Hassan Rakhshandeh,Abdolreza Norouzy,Habibollah Esmaily
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Guinea Pig,ileum,Rosa damascena,Aqueous Fractions,Cholinergic system
- چکیده:
- چکیده انگلیسی: Objective: The use of drugs with herbal origin is increasing for treatment of gastrointestinal (GI) disorders. Rosa damascena (R. damascena) is a well-known plant suggested to have beneficial effect on GI system. In this study, the effect of aqueous fraction of R. damascena on the contractionsofisolated guinea pig ileum was investigated.
Materials and Methods: Aqueous fraction of plant was obtained from ethanolic extract after ethyl acetate and n-butanol fractions were discarded. To evaluate effect of this fraction on ileum contraction, guinea pig ileum was removed and mounted on organ bath and its contraction was recorded. Effect of various concentrations (0.66, 0.83, and 1.3 mg/ml) of aqueous fraction on ileum contraction in comparison with Ach in presence and absense of atropine, a muscarinic antagonist of cholinergic, was evaluated. The response of ileum to 1 µg/ml of acetylcholine was considered as 100% response.
Results:Our results showed that aqueous fractions of R. damascena dose-dependently increased basal guinea pigs ileum contractions (pConclusion: It is concluded that aqueous fraction of R. damascena has mild excitatory effect on ileum contraction and this fraction may be beneficial as a mild laxative agent.- انتشار مقاله: 05-10-1391
- نویسندگان: Karim Dolati,Hassan Rakhshandeh,Mohammad Naser Shafei
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Coriandrum sativum,Appetite,Energy intake
- چکیده:
- چکیده انگلیسی: Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coriandrum sativum (coriander) hydroalcoholic extract was investigated on food intake in rats.
Material and Methods: Thirty male Wistar rats were randomly divided into five groups. Two control groups were used, one group received 0.5 ml water per day (vehicle group), and another group did not receive anything (control group). The other 3 groups were daily treated by 50, 100 or 150 mg/kg of coriander for 7 days, respectively. The daily amount of the food eaten by each rat was measured for 10 days. The amount of energy intake of each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Result: There was no significant change in energy intake between control and vehicle groups. The change in energy intake after treatment by 100 and 150 mg/kg of the extract was significantly higher than other groups (p=0.030 and p=0.007)
Conclusion: This study indicated that coriander had positive effects on appetite of rats. Future studies are needed to evaluate the mechanisms of the effects of this plant on appetite.
- انتشار مقاله: 07-05-1391
- نویسندگان: Mohsen Nematy,Maryam Kamgar,Seyed Mohammad Reza Mohajeri,Azita Aghaei,Hassan Rakhshandeh,Habibollah Esmaily,Majid Ghayour-Mobarhan,Michael Patterson
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Neuroprotective,Coriandrum sativum,Glucose/serum deprivation,PC12
- چکیده:
- چکیده انگلیسی: Objective: This study was planned to investigate whetherCoriandrum sativum (C. sativum) is capable of protecting neurons against glucose/serum deprivation (GSD)-induced cytotoxicity. Material and Methods: The PC12 cells were cultivated for 24 h in standard media (high-glucose DMEM containing Fetal Bovine Serum) or for 6 h in GSD condition (glucose-free DMEM, without serum) in the absence or presence of various concentrations (0.1, 0.2, 0.4, 0.8 and 1.6 mg/ml) of hydro-alcoholic extract (HAE), water fraction (WF), ethyl acetate fraction (EAF) or N-butanol fraction (NBF) of this plant. At the end of the treatments, the cell viability was determined using MTT assay. Results: With the exception of 1.6 mg/ml of EAF or NBF which decreased cell survival, the HAE and its fractions exhibited no cytotoxicity under standard condition. Exposure of the cells to GSD condition showed 52% decrease in the viability. In this condition, the HAE, EAF and NBF not only failed to increase cell viability but also increased the toxicity. On the other hand, WF at 0.4, 0.8 and 1.6 mg/ml significantly attenuated the GSD-induced decrease in cell survival. Conclusion: The present study revealed that C. sativum bearing water-soluble compound(s) could induce neuroprotective activity. Also, we showed that some constituents from this plant may serve as cytotoxic agents under stressful conditions like hypoglycemia and serum limitation.
- انتشار مقاله: 01-02-1390
- نویسندگان: Ahmad Ghorbani,Hassan Rakhshandeh,Elham Asadpour,Hamid Reza Sadeghnia
- مشاهده