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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Barriers,Screening,Breast cancer,Mammogram,KAP
- چکیده:
- چکیده انگلیسی: Objectives: Regular screening for breast cancer is associated with better survival, but compliance with guidelines
depends on good knowledge and attitudes. This study aimed to assess the level of breast cancer knowledge, attitudes
and screening practices in Lebanese females, and identify their socio-demographic determinants as well as barriers to
mammography use. Methods: This cross-sectional study was conducted with 371 Lebanese females residing in Beirut
aged 18-65 with no history of breast cancer. The questionnaire applied was adapted from Stager and Champion.
The overall knowledge score was determined with sections on general knowledge, curability, symptoms, and screening;
the overall attitude score concerned attitudes towards breast cancer, screening, and barriers; and the overall practices
score was for breast self examination (BSE), clinical breast examination (CBE) and mammography. Bivariate and
multivariate analyses of socioeconomic determinants were performed for each score. Results: The mean knowledge
score was 55.5±17.1% and that for attitudes was 71.9±8.3%. For self-examination, mammography and clinical
examination practices, individual means were 45.7±42.3%, 77.9±36.5% and 29.1±45.5%, respectively. Knowledge,
attitudes and practices correlated positively with each other (p<0.0001). The highest average was the knowledge
of symptoms (72.8±24.7%), and the lowest that of curability (49.6±25.7%). Most frequent barriers to mammography
were fear of learning bad news, pain, costs, and staff unpleasantness. Higher education was associated with better
knowledge (p=0.002) and smoking with lower levels (p=0.003). Older age (p=0.002), higher education (p=0.02),
and taking exercise (p=0.02) were associated with better attitudes. Higher education (p=0.02) and having children
(p=0.003) were associated with better practices. Conclusion: More emphasis should be placed on educating females
on the curability of breast cancer and specific targeting of the barriers identified.- انتشار مقاله: 11-12-1395
- نویسندگان: Margueritta El Asmar,Amer Bechnak,Johny Fares,Dana Al Oweini,Ahmad Al Razim,Adnan El Achkar,Hani Tamim
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: NAT2,bladder cancer,Lebanese
- چکیده:
- چکیده انگلیسی:
Background: In Lebanon, bladder cancer (BC) has an unusually high prevalence. Individuals who are exposed to aromatic amines from smoking or certain occupations and carrying the slow N-acetyl transferase 2 (NAT2) acetylator’ phenotype may be at a higher risk. Methods: Data and DNA from 115 Lebanese BC cases and 306 controls were examined. Ten NAT2 single nucleotide polymorphisms were genotyped, seven of which were then included in haplotype and phenotype analysis. Results: BC patients were more likely to be males (87.8% vs. 54.9%) and current smokers (60.9% vs. 26.5%) when compared to controls. In both groups, most participants had the slow NAT2 acetylator phenotype (66.1% of BC cases vs 62.7% of controls; P=0.302) with the NAT2*5B and *6A haplotypes being the most common. The odds ratio (95%CI) of having BC among slow NAT2 acetylators was 1.157 (0.738-1.815) and remained non-significant after adjustment [1.097 (0.666-1.806)]. Sensitivity analysis with a subgroup of 113 cases and 84 controls for which occupational history was available revealed a statistically significant association between slow NAT2 acetylators and BC in females only. The sample size was however very small and the CI quite wide. Conclusions: This is the first study to evaluate the distribution of NAT2 haplotypes and their potential role in BC in a Lebanese population. The absence of any significant association may be due to the relatively small sample size, the unavailability of matching by gender, and the lack of evaluation of genetic interactions with extent of active and passive smoking, exposure to environmental pollutants, diet, and other genes. The potential association limited to females needs further evaluation.- انتشار مقاله: 26-04-1396
- نویسندگان: Rami Nasr,Sally Temraz,Deborah Mukherji,Ali Shamseddine,Reem Akika,Sehrish Abbasi,Raja Khauli,Muhammad Bulbul,Hani Tamim,Nathalie K Zgheib
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: NAT2,bladder cancer,Lebanese
- چکیده:
- چکیده انگلیسی:
Background: In Lebanon, bladder cancer (BC) has an unusually high prevalence. Individuals who are exposed to aromatic amines from smoking or certain occupations and carrying the slow N-acetyl transferase 2 (NAT2) acetylator’ phenotype may be at a higher risk. Methods: Data and DNA from 115 Lebanese BC cases and 306 controls were examined. Ten NAT2 single nucleotide polymorphisms were genotyped, seven of which were then included in haplotype and phenotype analysis. Results: BC patients were more likely to be males (87.8% vs. 54.9%) and current smokers (60.9% vs. 26.5%) when compared to controls. In both groups, most participants had the slow NAT2 acetylator phenotype (66.1% of BC cases vs 62.7% of controls; P=0.302) with the NAT2*5B and *6A haplotypes being the most common. The odds ratio (95%CI) of having BC among slow NAT2 acetylators was 1.157 (0.738-1.815) and remained non-significant after adjustment [1.097 (0.666-1.806)]. Sensitivity analysis with a subgroup of 113 cases and 84 controls for which occupational history was available revealed a statistically significant association between slow NAT2 acetylators and BC in females only. The sample size was however very small and the CI quite wide. Conclusions: This is the first study to evaluate the distribution of NAT2 haplotypes and their potential role in BC in a Lebanese population. The absence of any significant association may be due to the relatively small sample size, the unavailability of matching by gender, and the lack of evaluation of genetic interactions with extent of active and passive smoking, exposure to environmental pollutants, diet, and other genes. The potential association limited to females needs further evaluation.- انتشار مقاله: 26-04-1396
- نویسندگان: Rami Nasr,Sally Temraz,Deborah Mukherji,Ali Shamseddine,Reem Akika,Sehrish Abbasi,Raja Khauli,Muhammad Bulbul,Hani Tamim,Nathalie K Zgheib
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: NAT2,bladder cancer,Lebanese
- چکیده:
- چکیده انگلیسی:
Background: In Lebanon, bladder cancer (BC) has an unusually high prevalence. Individuals who are exposed to aromatic amines from smoking or certain occupations and carrying the slow N-acetyl transferase 2 (NAT2) acetylator’ phenotype may be at a higher risk. Methods: Data and DNA from 115 Lebanese BC cases and 306 controls were examined. Ten NAT2 single nucleotide polymorphisms were genotyped, seven of which were then included in haplotype and phenotype analysis. Results: BC patients were more likely to be males (87.8% vs. 54.9%) and current smokers (60.9% vs. 26.5%) when compared to controls. In both groups, most participants had the slow NAT2 acetylator phenotype (66.1% of BC cases vs 62.7% of controls; P=0.302) with the NAT2*5B and *6A haplotypes being the most common. The odds ratio (95%CI) of having BC among slow NAT2 acetylators was 1.157 (0.738-1.815) and remained non-significant after adjustment [1.097 (0.666-1.806)]. Sensitivity analysis with a subgroup of 113 cases and 84 controls for which occupational history was available revealed a statistically significant association between slow NAT2 acetylators and BC in females only. The sample size was however very small and the CI quite wide. Conclusions: This is the first study to evaluate the distribution of NAT2 haplotypes and their potential role in BC in a Lebanese population. The absence of any significant association may be due to the relatively small sample size, the unavailability of matching by gender, and the lack of evaluation of genetic interactions with extent of active and passive smoking, exposure to environmental pollutants, diet, and other genes. The potential association limited to females needs further evaluation.- انتشار مقاله: 26-04-1396
- نویسندگان: Rami Nasr,Sally Temraz,Deborah Mukherji,Ali Shamseddine,Reem Akika,Sehrish Abbasi,Raja Khauli,Muhammad Bulbul,Hani Tamim,Nathalie K Zgheib
- مشاهده