در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Leptin,HCC,Adiponectin,Visfatin,Adipokines
- چکیده:
- چکیده انگلیسی: Background: Adipokines play an important role in the regulation of inflammation and tumor progression. Aim: Assessment of the possible role of adiponectin, leptin and visfatin in HCV associated hepatocellular carcinoma (HCC). Methods: patients were classified into 85 patients with HCV associated HCC, 100 patients with chronic hepatitis C viral (HCV) infection compared to 50 normal control (NC) subjects. All subjects included in the study were assessed for HCV infection by seropositive HCV antibodies, as well as HCV RNA by RT-PCR. Serum levels of adiponectin, leptin and visfatin were assessed using enzyme linked immunosorbent assay (ELISA). The data were correlated to the relevant clinic-pathological features of the patients, and the overall survival (OS) rate. Results: There was a significant difference in the serum levels of adiponectin and visfatin among HCC, HCV and NC groups (P<0.001). The serum levels of leptin and alpha fetoprotein (AFP) were significantly higher in HCC group (P<0.001). There was a significant association between the serum level of adiponectin and advanced Child class liver cirrhosis (P=0.03), as well as with poor performance status (ECOG, P=0.02). Serum leptin associated significantly with the number of lesions in the liver (P=0.006), visfatin associated with increased mortality rate (P<0.001). Adiponectin, leptin and visfatin associated significantly with liver cirrhosis in HCV patients (P<0.01). Leptin achieved the highest sensitivity (98.8%). visfatin achieved the highest specificity (100%) and PPV (100%) for detection of HCC. The combination of serum leptin and visfatin for the diagnosis of HCV associated HCC showed sensitivity, specificity, PPV, NPV and accuracy (100%, 96.6%, 93.4%, 100% and 97.4%; respectively). Conclusion: Adiponectin, leptin and visfatin have an important role(s) in the pathogenesis of HCV associated HCC.
- انتشار مقاله: 24-12-1397
- نویسندگان: Usama M El-Daly,Magdy M Saber,Mona S Abdellateif,Hanan R Nassar,Alfred E Namour,Yahia M Ismail,Abdel-Rhaman N Zekri
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: TOP2A,CEP17 polysomy,anthracyclines,TNBC
- چکیده:
- چکیده انگلیسی: Objective: Triple negative breast cancer is an aggressive variant of breast cancer; it forms about 15% of breast
cancer cases. It lacks the responsiveness to hormonal and targeted therapies. Anthracyclines remain the treatment option
for these patients. Anthracyclines are cardiotoxic, so predicting sensitivity of response by biological predictors may
have a role in selecting suitable candidates for these drugs. Material and methods: This study included 50 TNBC
cases, from National Cancer Institute, Cairo University(NCI-CU), Egypt, who underwent surgery and received adjuvant
chemotherapy. Archived blocks were obtained and immunostaining for Ki-67 LI and Fluorescent In situ Hybridization
(FISH) technique to assess TOP2A gene copy number and chromosome 17CEP status were done. Analysis of association
between TOP2A alterations and CEP17 polysomy as well as Ki-67 LI with other clinicopathological parameters was
done. Associations between the biological markers and event free survival (EFS) and overall survival (OS), were also
performed. Results: TOP2A alteration was seen in 9/50 cases (5 amplified and 4 deleted). CEP17 Polysomy was detected
in 14% of cases. Most of patients (80%) showed Ki-67 LI ≥20%. There was a significant association between TOP2A
gene and CEP17 status. Outcome was better with abnormal TOP2A gene status and CEP17 polysomy, radiotherapy
and combined anthracyclines and taxanes in the adjuvant setting, however P-values were not significant. Conclusion:
TOP2A gene alterations and CEP17 polysomy may have prognostic and predictive role in TNBC treated with adjuvant
Anthracyclines.- انتشار مقاله: 10-03-1397
- نویسندگان: Mahitab Ibrahim Eltohamy,Omnia Mohammed Badawy,Naglaa El Kinaai,Iman Loay,Hanan Ramadan Nassar,Rasha Mahmoud Allam,Mona Ali Sakr
- مشاهده