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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Malononitrile,One-pot synthesis,Multicomponent reaction,Triphenyl phosphine,Pyrans
- چکیده:
- چکیده انگلیسی: Triphenyl phosphine(PPh3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4H-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in EtOH-H2O (1:1) at reflux conditions. The results show that aromatic aldehydes containing electron-donating groups or electron-withdrawing groups could react smoothly to give the corresponding products in good
to excellent yields. Given the increasing levels of interest in green chemistry, the recyclability and reusability of the catalyst have been evaluated. It was also found that triphenyl phosphinecan be recycled at least four times without loss of activity. This method has the advantages of high yield,mild reaction conditions, environmentally benign methodology and short reaction time.- انتشار مقاله: 29-09-1394
- نویسندگان: Harikrishnan Ramadoss,Hamzeh Kiyani,Syed Sheik Mansoor
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Teucrium Polium,Prosopis Farcta,Sirt3,ROS
- چکیده:
- چکیده انگلیسی:
Background: Teucrium Polium and Prosopis Farcta have been traditionally employed in cancer treatment. In this study we evaluated the effects of methanolic extracts of these two plants in HT-29 cells. Methods: IC50s of extracts were obtained via MTT assay and the levels of ROS production, cell death, collapse of mitochondrial membrane potential and Sirt3 enzyme activity were determined. Results: After 48 hours exposure, IC50s for Teucrium and Prosopis extracts were 3 and 2μg/ml, respectively. Extracts induced higher ROS production after 6 hours than after 12 hours. Mitochondrial membrane potential collapse and cell death rate were also increased; Teucrium caused greater cell death than Prosopis. Extracts from both plants increased Sirt3 activity in its normal form, but only Teucrium extract caused a significant increase in activity of Sirt3 enzyme isolated from cancer cells. Conclusion: Teucrium and Prosopis extracts exert anticancer activity via mitochondrial alterations, as exemplified by increased ROS levels, Sirt3 activity and cell death in HT-29 colorectal cancer cells.- انتشار مقاله: 03-05-1396
- نویسندگان: Forouzan Khodaei,Kiyanoosh Ahmadi,Hamze Kiyani,Mahmoud Hashemitabar,Mohsen Rezaei
- مشاهده