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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Pentoxifylline,Hepatopulmonary syndrome
- چکیده:
- چکیده انگلیسی: Introduction: Hepatopulmonary syndrome (HPS) is known as a chronic liver disease associated with severe pulmonary deoxygenation due to intrapulmonary vascular vasodilation. Although liver transplantation is accepted as a main treatment of HPS, identifying effective drugs for recovery of HPS can be effective in postponing the transplantation and decreasing the mortality rate of patients before the transplantation. In this study we briefly reviewed the pathogenesis of HPS and also systematically reviewed the current pharmacological treatment of HPS.
Method: Pubmed, Scopus, and Google scholar were searched for the relevant English language clinical and experimental articles about the medications used in the treatment of HPS.
Results: A total of 38 articles were included in this study which mostly resulted in decreasing NOS expression, NO production, endothelin-1 activation, intrapulmonary angiogenesis and increasing oxygenation.
Conclusion: Various drugs have been proposed in treatment of HPS but more large controlled trial studies, is necessary to determine the exact efficacy of each drugs for HPS recovery.- انتشار مقاله: 16-11-1392
- نویسندگان: Leili Zarifmahmoudi,Maryam Khalesi,Ramin Sadeghi,Seyed Ali Jafari,Mohammad Ali Kiani,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: liver disease,Pentoxifylline,Hepatopulmonary syndrome
- چکیده:
- چکیده انگلیسی: Introduction: Hepatopulmonary syndrome (HPS) is known as a chronic liver disease associated with severe pulmonary deoxygenation due to intrapulmonary vascular vasodilation. Although liver transplantation is accepted as a main treatment of HPS, identifying effective drugs for recovery of HPS can be effective in postponing the transplantation and decreasing the mortality rate of patients before the transplantation. In this study we briefly reviewed the pathogenesis of HPS and also systematically reviewed the current pharmacological treatment of HPS.
Method: Pubmed, Scopus, and Google scholar were searched for the relevant English language clinical and experimental articles about the medications used in the treatment of HPS.
Results: A total of 38 articles were included in this study which mostly resulted in decreasing NOS expression, NO production, endothelin-1 activation, intrapulmonary angiogenesis and increasing oxygenation.
Conclusion: Various drugs have been proposed in treatment of HPS but more large controlled trial studies, is necessary to determine the exact efficacy of each drugs for HPS recovery.- انتشار مقاله: 16-11-1392
- نویسندگان: Leili Zarifmahmoudi,Maryam Khalesi,Ramin Sadeghi,Seyed Ali Jafari,Mohammad Ali Kiani,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Pediatric,Ingestion,Key words: Foreign body
- چکیده:
- چکیده انگلیسی: Introduction: Determination of type and location of trapped objects and endoscopic observations among children with foreign-body ingestion.
Materials and Methods: We evaluated 105 endoscopic records of patients presenting with foreign-body ingestion from 2001–2011.
Results: Button batteries were the most common objects removed (41%). The lower segment of the esophagus was the most common trapping site. There was significant correlation between type of foreign body and its location of trapping. Abnormal endoscopic observations were reported in 33% patients. There was significant correlation between the type of foreign body and endoscopic observations. There was also a significant correlation between the location of the foreign body and endoscopic observation.
Conclusion: The pattern of foreign-body ingestion is somewhat different in our center compared with other studies. Awareness among parents about the prevention of this accident is an important step in decreasing the incidence of foreign-body ingestion.- انتشار مقاله: 23-09-1392
- نویسندگان: Seyed Ali Jafari,Maryam Khalesi,Simin Partovi,Mohammadali Kiani,Hamid Ahanchian,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: neonate,NICU,bacterial infection
- چکیده:
- چکیده انگلیسی: Background: Among the most common causes of death in preterm infants are neonatal infections, which remain high despite antibiotic therapy and preservative measures. The control of hospital infections is now a global priority, and many factors contribute to the spread of these infections. This study aimed to determine the frequency of bacterial infections in neonates and identify the common causes of infection in neonates admitted to the neonatal intensive care unit (NICU) of Alzahra Hospital in Isfahan, Iran.
Methods: In this cross-sectional study, the population consisted of all neonates who were admitted to the NICU of Al-Zahra Hospital in Isfahan, Iran, from April 2017 to March 2018. Neonates who had a positive culture (blood, cerebrospinal fluid, urine, eye discharge, and tracheal tube secretions) were enrolled. The data were collected by a structured questionnaire, including maternal and neonatal information.
Results: In this study, 56 newborns admitted to the NICU of Alzahra Hospital in Isfahan were studied. Their age range was within 5-28 days (18.88±8.41). Thirty-two (57.1%) neonates were male, and 24 (42.9%) newborns were female. In total, 26 (46.4%) neonates had prematurity that was the most common reason for hospitalization. The most isolated microorganisms were Staphylococcus epidermidis, Enterococcus, Klebsiella, Enterobacteriaceae, Candida spp., Acinetobacter, Streptococcus pneumoniae, E. coli, and Streptococcus viridans, respectively.
Conclusion: According to the results of this study, the frequency of nosocomial infections in the NICU of Alzahra Hospital in Isfahan was 7.4%. The findings of this study highlighted the importance of paying more attention to controlling and preventing hospital infections in NICUs.- انتشار مقاله: 15-07-1397
- نویسندگان: Milad Kabiri Samani,Majid Keivanfar,Hossein Firouzi,Seyed Javad Seyedi,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Growth,Allergy,Cow’s Milk,Proctocolitis
- چکیده:
- چکیده انگلیسی:
Background
Cow’s milk allergy is one of most prevalent food allergies worldwide. Due to elimination diet it can impair growth in infants. In this study we evaluate growth disorders in Non-immunoglobulin E mediated cow’s milk allergy named allergic proctocolitis.
Materials and Methods: Forty-nine patients were included in this longitudinal study. The study was launched from February 2018 to February 2019 in Akbar hospital, Mashhad-Iran. Cow’s milk allergy was diagnosed according to the clinical presentation and Challenge test. All participants were breastfed during the course of study. Mothers were received 1000 mg calcium and infants 400 IU Vitamin D daily, as routine. The cow’s milk was eliminated from the diet of both mother and infant. Infants were followed up for 9 months with 3 month intervals. Growth patterns were evaluated by measuring height, weight and head circumference z-scores every 3-months. Serum level of Calcium, Vitamin D, PTH and phosphorus were evaluated before and after the follow-up period.
Results: The mean age of the study participants was 4.57±2.41 month. There was a statistical significant difference between weight and height Z score (p=0.028) (p=0.001), respectively, at baseline and 9 months after treatment. However, no significant difference was found in head circumference Z-score at baseline and 9 months after treatment (p=0.564). The increase in Vitamin D and PTH along with the decrease in calcium, phosphorus was significant during the study period (p <0.01).
Conclusion
It seems that elimination diet in infants with cow’s milk allergy would not suppress growth parameters and might even improve it, especially weight gain.
- انتشار مقاله: 24-12-1398
- نویسندگان: Mohadese Khakpour,Nasrin Moazzen,Ali Khakshour,Samaneh Norouziasl,Saeedeh Talebi,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,Probiotics,Asthma
- چکیده:
- چکیده انگلیسی: Background: Asthma is a growing problem worldwide and the limitations of the current therapy for allergic asthma highlight the need for novel therapeutics. We conducted a systematic review and meta-analysis to find out the role of probiotics in the treatment of Asthma.
Materials and Methods: In this systematic review, a comprehensive search of the major electronic databases was done till October 2017. Clinical trials comparing the effect of probiotics versus placebo on treating asthma were included. Trials focusing on prevention of asthma were not included. A predefined set of outcome measures was assessed. Continuous data were expressed as standardized mean difference with 95% confidence interval (CI). Dichotomous data were expressed as odds ratio with 95% CI. P-value < 0.05 was considered as significant.
Results: 11 studies with 2,027 participants were included. Probiotic intake was associated with a significant improvement in pulmonary function test and slight benefits in asthma control test. Probiotics did not reduce asthma exacerbation and wheezing episodes although there was a high degree of heterogeneity in studies. It also has no significant effect on viral respiratory infection in asthmatics and no improvement in quality of life. Probiotic intake improved the following parameters: longer time free from episodes of asthma. Adverse events were not significant.
Conclusion: Although trials showed promising effects of probiotics as an additive on therapy on some parameters of asthma, as this evidence was generated from only a few trials with high degree of heterogeneity, routine use of probiotics as an additive on therapy of asthmatic patients cannot be recommended at this time.- انتشار مقاله: 14-09-1397
- نویسندگان: Hamid Ahanchian,Fatemeh Khorasani,Mohammad Ali Kiani,Maryam Khalesi,Elham Ansari,Seyed Ali Jafari,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,lead,Blood,Failure to Thrive
- چکیده:
- چکیده انگلیسی: Background
Lead is a strong and stable toxin, harmful especially to children, pregnant women, and the elderly. Nearly 27% of children aged under 5 years suffer from failure to thrive (FTT). Due to the probable harmful effects of lead poisoning on children’s growth, in this study we aimed to assess the blood lead level in children with unexplained failure to thrive.
Methods
This analytic cross-sectional study was performed on 200 children under 2 years of age who were referred to Ghaem hospital, a referral hospital in Mashhad city-Iran. The participants were divided into two equal groups, one with unexplained FTT (group A), and children with normal weight (group B). Baseline characteristics were obtained by a research-made questionnaire. Blood samples were taken by the hospital nurses who were blind to the study groups. Blood lead level was measured by atomic absorption spectrophotometric method (Perkin Elmer 3030).
Results
The mean ± standard deviation (SD) of blood lead level in FTT group and control group were 7.3±3.32 µg/dL and 6.37±5.93 µg/dL, respectively. Blood lead level was significantly higher in FTT group than control group (P=0.001). Baseline Charactistics (such as hgender, parental educational level, gestational age, and socio-economic status of the family) were not significantly different between the two groups (P>0.05).
Conclusion
The results of our study revealed that blood lead level was higher in children with FTT. So Lead poisoning may be a potential cause of unexplained FTT. So, measuring blood lead level can be useful in diagnostic workup of patients with FTT.- انتشار مقاله: 16-09-1397
- نویسندگان: Simin Torabian,Mohammad Ali Kiani,Alizadeh Ghamsari Anahita,Seyed Ali Jafari,Masumeh Saeidi,Ali Khakshour,Seyed Javad Sayedi,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Probiotics,Pediatrics,Diarrhea,Yogurt consumption
- چکیده:
- چکیده انگلیسی: Background
The popularity of probiotics is on the rise. Despite the beneficial effects of antibiotics, gastrointestinal health is at risk of diarrhea. This study aimed to investigate whether probiotic yogurt is of capability to prevent the incidence of diarrhea versus conventional yogurt.
Materials and Methods
This controlled, randomized, double-blind trial was designed to recruit 48 hospitalized children, whose treatments included different types of antibiotics. They were subsequently assigned into a 1:1 ratio into groups A and B at random. The first group was instructed to consume probiotic yogurt (Bifidobacterium strains and Lactobacillus acidophilus), while the second were on conventional yogurt (placebo containing Streptococcus thermophiles and Lactobacillus bulgaricus) at least for 7 days. The incidence of diarrhea, its onset and duration were compared between the two groups.
Results
The findings indicated that there was no statistically significant difference between the experimental and control groups (p > 0.05). No significant decrease was observed in the incidence of diarrhea between the groups following adjustment for negative C-reactive protein (CRP) (p > 0.05).
Conclusion
According to the results, the consumption of yogurt, either probiotic or conventional, reduced the incidence, duration, and onset of antibiotic-associated diarrhea in pediatric population. This study showed no significantly better performance for probiotic yogurt than conventional yogurt.- انتشار مقاله: 25-07-1396
- نویسندگان: Majid Khademian,Mohammad Ali Kiani,Seyed Ali Jafari,Hamid Ahanchian,Niloofar Sedghi,Fatemeh Behmanesh,Ali Khakshour,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: anxiety,children,depression,Celiac disease,Gluten free diet
- چکیده:
- چکیده انگلیسی: Background
Celiac disease (CD) is a systemic autoimmune disorder due to immune response triggered by ingestion of gluten in the diet. Treatment with lifelong gluten-free diet may impact negatively on the health-related quality of life and may lead to psychological disturbances. The purpose of study was to evaluate quality of life, depression and anxiety in children with celiac disease.
Materials and Methods
In this cross-sectional study was done between 2013 and 2014 at the Gastroenterology Outpatient Clinic (Ghaem Hospital, Mashhad- Iran), patients with serology and biopsy-proven CD, on a gluten-free diet for at least one year, were included in this study and compared with non-celiac healthy children as controls. We used the questionnaire to investigate quality of life, anxiety and depression.
Results
There were statistically significant differences between the mean total anxiety (state, trait) scores and depression score in the celiac patients and control group. Correlations between state and trait anxiety and depression were statistically significant (P= 0.01, r= 0.35) and (P= 0.001, r= 0.52). Reverse correlations between quality of life of CD children and anxiety (state, trait) were statistically significant (P= 0.001, r= 0.51 and P= 0.02, r= 0.32). Mean total score of quality of life was not different in the two groups, but in the physical activity component, quality of life was better in CD patients (P=0.008).
Conclusion
In current study, anxiety and depression had a significant impact on the course of celiac disease.- انتشار مقاله: 06-03-1396
- نویسندگان: Seyed Ali Jafari,Saeedeh Talebi,Nazanin Mostafavi,Fatemeh Moharreri,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Valproic acid,Liver failure,Liver transaminases
- چکیده:
- چکیده انگلیسی: Introduction
Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other
antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity.
The aim of this study was to investigate valproic acid impact on liver transaminases
at the beginning of VPA treatment and after three and six months of it.
Materials and Methods
This study was designed as a cross sectional project in Pediatrics Neurology
ward of a Tertiary Academic Hospital (Ghaem Hospital, Mashhad-Northeastern
Iran). All children who needed valproic acid therapy alone were selected for study.
Liver function test was performed for them at the beginning of VPA administration,
three and six months after VPA, respectively. Data was analyzed by SPSS version 16.
Results
60 children with mean age of 49±28.6 months were entered the study.
37 of them were male and 23 were female. 5% (3 children) were mental retard
and 11.7% (7 patients) had neurologic or developmental deficit. Mean value of
Aspartate Aminotransferase (AST), Alanine Transferase (ALT) and Alkaline
phosphatase (ALP) were 27, 30.8 and 30.4 and 17.4, 20.7 and 22.8 and 425,
426 and 441 at the beginning of VPA administration, three and six months after
VPA, respectively. In six months of our follow up, only one child (1.7%) had elevated
liver transaminases.
Conclusion
Regard to our findings and its agreement with previous researches, it is important to
control adverse drug events by measuring liver transaminases during antiepilepsy treatment.- انتشار مقاله: 20-01-1394
- نویسندگان: Javad Akhondian,Mohammad Ali Kiani,Seyed Ali Jafari,Mehran Beiraghi Toosi,Mansoureh Mirzaei Najm Abad,Hamid Ahanchian,Hamidreza Kianifar
- مشاهده