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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Azo-azomethine,Colorimetric detection,Chemosensor,Fluoride ion recognitio
- چکیده:
- چکیده انگلیسی: A new azo-azomethine chemosensor containing active phenolic sites, H2L, has been designed and synthesized for rapid detection of inorganic fluoride over the other anions, such as Clˉ, Brˉ, Iˉ, AcOˉ, H2PO4ˉ, NO3ˉ, N3ˉ in DMSO/water (90/10) media. The 1H NMR titration revealed that the colorimetric response was considered to be the direct consequence of hydrogen-bond formation between phenolic groups of the receptor and fluoride ion followed by deprotonation. The anions recognition ability of H2L was also evaluated using UV-Vis spectroscopy. Importantly, H2L can detect inorganic fluoride even at 2.04×10-6 M level, which is lower than the World Health Organization (WHO) permissible level. Interestingly, H2L was used for qualitative detection of fluoride anion in commercially available mouthwash and toothpaste.
- انتشار مقاله: 21-02-1398
- نویسندگان: Hamid Khanmohammadi,Khatereh Rezaeian,Hadis Radaie
- مشاهده
- جایگاه : پژوهشی
- مجله: Interdisciplinary Journal of Virtual Learning in Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: eLearning,Presence Education,Continuous Medical Education
- چکیده:
- چکیده انگلیسی: Introduction: E-learning in a manner to facilitate and promote learning by helping ICT based tools. The main objective of this study Comparison of knowledge and satisfaction of general practitioners participating in diabetes training courses by eLearning (offline) and the traditional education. Material & Methods: This quasi-experimental research was performed on general practitioners who had participated in Diabetes continuous medical education (CME). All research cases (74 cases), after filling pre-test questionnaire randomly divided into two groups: one group of traditional practices and retraining in another group of e-learning methods were used. 2-4 weeks later, they filled a posttest questionnaire. The data gathering tool was the questionnaire which completed by the research samples.Results: There was a significant correlation between pretest and posttest scores and the posttest scores were significantly more than the pretest ones in eLearning group (P < 0.01). There was a significant correlation between the research samples' accessibility to computer and their satisfaction to eLearning approach (P < 0.03).Conclusion: Findings generally showed the e-learning was an effective approach to create deep and lasting learning in the participant of continuous medical education
- انتشار مقاله: 11-10-1398
- نویسندگان: Nahid Zarif Sanaiey,Zohreh Karamizadeh,Ali Akbar Faghihi,Hamid Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,amino acid,Nutraceuticals,Cytoprotection,Mitochondrial cytopathies
- چکیده:
- چکیده انگلیسی: Taurine (TAU) is the most abundant free amino acid in the human body. High concentrations of this amino acid are found in tissues such as the skeletal muscle, brain, and kidney. Recently, a focus has emerged on the effects of TAU on cellular mitochondria. It has been found that TAU could positively affect this organelle by enhancing mitochondrial membrane potential, increasing ATP levels, and mitigating mitochondria-mediated ROS formation. The current study aimed to evaluate the effect of a wide range of TAU concentrations (0.01 mM-1000 mM) on mitochondrial function. Mice liver mitochondria were isolated and exposed to different concentrations of TAU (30 min). Several indices, including mitochondrial depolarization, dehydrogenases activity, permeabilization, and ATP content, were monitored. It was found that TAU supplementation significantly enhanced parameters such as mitochondrial ATP levels and mitochondrial membrane potential in comparison with the control group. Moreover, TAU prevented Ca2+-induced mitochondrial permeabilization. This amino acid revealed no significant adverse effect on isolated mitochondria even at very high and supra-physiological concentrations (e.g., 100, 250, and 500 mM). These data suggest TAU as an ideal and safe agent to protect mitochondria against toxic insults or regulating cellular function in different mitochondria-linked disorders.
- انتشار مقاله: 21-08-1398
- نویسندگان: Hamidreza Mohammadi,Mohammad Mehdi Ommati,Omid Farshad,Akram Jamshidzadeh,Mohammad Reza Nikbakht,Hossein Niknahad,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Heavy metals are environmental pollutants which pose toxicity toward biological systems. Most organs are susceptible to heavy metals-induced toxicity. Hence, finding protective agents against heavy metals-induced toxicity is valuable. The post-nuclear supernatant (PNS) has been accepted as an in vitro model for assessing xenobiotic-induced toxicity toward biological systems. Monitoring the toxic effects of a large number of xenobiotics in a short time is one of the superiorities of PNS system. The goal of the present study was to validate the PNS as an in vitro model for investigating the effect of heavy metals (Cd, Co, Cu, Fe, As, Hg, Cr, and Pb)-induced toxicity and evaluating the potential protective effects of glycine and betaine. Markers of oxidative stress including ROS formation, lipid peroxidation and glutathione content in addition of succinate dehydrogenase activity (MTT test) were monitored in the presence of heavy metals alone or in combination with glycine (1 mM) and betaine (100 µM). Our results suggest that PNS preparations can be used as an appropriate model for future investigation of xenobiotics-induced toxicity and estimation of the protective properties of different agents. Indeed, further evaluations in other experimental models could reveal the protective properties of betaine and glycine against heavy metals-induced organ injury.
- انتشار مقاله: 12-03-1397
- نویسندگان: Reza Heidari,Hamidreza Mohammadi,Asrin Ahmadi,Vahid Ghanbarinejad,Faraz Kasra,Amir Khosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: The xenobiotics-induced liver injury is a major clinical complication. Hence, finding hepatoprotective agents could have clinical value. Herbal medicines are a major source of biologically active chemicals which could be applied as hepatoprotective agents. The current study was designed to assess the hepatoprotective properties of Avicennia Marina (AM) extract and its different fractions. In vivo, the hepatoprotective effect of AM total extract against CCl4-induced acute liver injury was evaluated in rats, and a series of histopathological, biochemical, and oxidative stress parameters were monitored. In vitro, the protective effect of AM extract fractions (Petroleum ether, Chloroform, Ethyl acetate, and Ethanol) was evaluated on human liver hepatoma cells (HepG2). Severe elevation in serum level of liver injury biomarkers, along with liver tissue histopathological changes, lipid peroxidation, and liver tissue glutathione depletion were detected in CCl4-treated rats. On the other hand, CCl4-induced toxicity was evident in vitro by significant cell death. It was found that AM extract provided significant protection against CCL4 toxicity in vivo by decreasing serum biomarkers of liver injury and tissue markers of oxidative stress. In vitro, the protective effect of AM extract fractions (Chloroform, Ethyl acetate, and Ethanol) was evident as these fractions significantly decreased CCl4 cytotoxicity. As AM extract exhibited significant suppression of oxidative stress markers, its antioxidant effect could play a significant role in its hepatoprotective properties.
- انتشار مقاله: 29-08-1396
- نویسندگان: Omid Farshad,Reza Heidari,Hamidreza Mohammadi,Amin Reza Akbarizadeh,Mohammad M. Zarshenas
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: CYP1A1,Ketoconazole,omeprazol,aryl hydrocarbon receptor (AHR),FICZ
- چکیده:
- چکیده انگلیسی: Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity. The aim of this study was to investigate whether KTZ and OMP can act as indirect activator of AHR. In order to evaluate the effects of KTZ and OMP on AHR signaling, we measured cytochromes p450 (CYP1A1) enzyme activity by ethoxyresorufin-O-deethylase (EROD) assay as endpoint. FICZ, at 1nM concentration, caused a transient elevation in the catalytic activity of CYP 1A1. KTZ and OMP were found to be inducer of CYP1A1 at concentrations above 50 µM. At early time of incubation (3hr), a dose-dependent inhibition of FICZ-induced EROD activity was seen. When OMP or KTZ were added together with FICZ, a prolonged activation of CYP1A1 was observed at later time of incubation (24h). Taken together, our findings support the earlier observation that we shown that CYP 1A1 inhibitors can act as an AHR activator though inhibition of metabolic degradation of FICZ.
- انتشار مقاله: 24-10-1395
- نویسندگان: Ali Ghaffarian-Bahraman,Nilofar Sadeghimanesh,Mona Mirzaei,Amin-Reza Akbarizadeh,Mahmoud Omidi,Hamidreza Mohammadi,Mohammad-Reza Arabnezhad,Keivan Mobini,Afshin Mohammadi-Bardbori
- مشاهده
- جایگاه : پژوهشی
- مجله: space ontology international journal
- نوع مقاله: Journal Article
- کلمات کلیدی: theory,New Urbanism,Good community,Civilization,Critism
- چکیده:
- چکیده انگلیسی: In the wake of Jacobs’s criticisms of planning, planners increasingly felt a level of angst over, or even responsibility for, the condition of the city. Schooled in preparing and implementing plans and land use regulations, they appreciated the appeal of a new movement that offered a simple, tangible, and marketable recipe for practice. New urbanism theory is one of the contemporary urban theories that developed as a movement within practice as a response to the failure of cities and suburbs in the mid-twentieth century. Now these questions take shape in a mind: May New Urbanism lead to Planning good community? How is new urbanism developing theory, and how does it contribute to our understanding of theory? How is planning theory responding to new urbanism and the insights its practice generates? These are questions that the paper tried to answer them. Using content analysis, various ideas and views about New Urbanism and its formation from theory to practice have been reviewed and criticized. We concluded that although the new urbanists want to turn the situation around and they envision cities without suburbs, but in practice, they could not make good community According to the principles that this normative theory committed. In present day most new urbanist projects have proven relatively homogeneous in composition. Rather than minimizing difference, new urbanist projects have sometimes exacerbated societal differences by creating enclaves of affluence in the urban environment.
- انتشار مقاله: 30-04-1396
- نویسندگان: Mitra Ghorbi,Hamid Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Sociological of Studies of youth
- نوع مقاله: Journal Article
- کلمات کلیدی: Modernism,Moral vulnerability,Consumer values,Social acceptability,Traditional-religious commitment reduction
- چکیده:
- چکیده انگلیسی: Pathology and determination of students' moral vulnerability is significant step in their security against cultural, social, value, and moral changes. The present study has been done to assess the students' moral vulnerability. The theoretical framework composed of theories of Durkheim, Englehart and Lerner. By the survey technique, this study has examined the relationship between the moral vulnerability rate and socio-cultural factors influencing it among male students in the city of Yazd. The number of 386 persons was selected by multi-stage cluster sampling method for statistical sample. The research findings show that there was no significant relationship between the media usage and moral vulnerability. Multivariate regression analysis showed that variables of social acceptance, traditional -religious commitment reduction and western lifestyle explained 63% of the variance of the dependent variable of moral vulnerability.
- انتشار مقاله: 12-02-1396
- نویسندگان: Mahnaz Farahmand,Hamid Mohammadi,Mehdi Alinezhad
- مشاهده
- جایگاه : پژوهشی
- مجله: Pistachio and Health Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Antifungal,Nanoparticles,Aflatoxins,Aspergillus
- چکیده:
- چکیده انگلیسی: Aflatoxins (AFs) are fungal subsidiary products that are predominantly generated by Aspergillus flavus and Aspergillus
parasiticus strains on cereals, nuts, dried fruits and dairy products under warm and humid conditions. Harmful fungi cause
spoilage in agricultural crops, and mycotoxins exert harmful effects on humans and livestock. Pistachios (Pistachio vera L) are
from among the most well-known nut trees extremely susceptible to contamination by aflatoxins and the major contributors to
dietary aflatoxins. Aflatoxins, in particular aflatoxin B1 (AFB1), are from among the most toxic natural compounds with
carcinogenic effects. Besides, exposure to aflatoxins results in several health-related conditions in humans, including acute and
chronic aflatoxicosis, immune suppression, liver cancer/cirrhosis, and stunting. Some traditional and novel control strategies
have been proposed for the elimination of AF prevalent in food crops. The application of nanoparticles is a newly advanced
method where they are used as antibacterial, antifungal, antiviral, anti-inflammatory, and anticancer agents. Nanoparticles are
most widely used for the molecular detection of pathogens at the early stages of the plant growth and for the control of
diseases. In this paper, the utilization and effects of nanomaterials on controlling aflatoxigenic fungi and their toxicity on
pistachio nuts have been studied.
- انتشار مقاله: 22-02-1397
- نویسندگان: Fatemeh Hassanzadeh Davarani,Milad Ashrafizadeh,Roohollah Saberi Riseh,Elham Ghasemipour Afshar,Hamid Mohammadi,Seyed Hamid Razavi,Ali Mandegary,Reza Mohammadinejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Research Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Green synthesis,Myrtus Communis,Thalassemia,Silver nanoparticle,Hydrolyzable Tannins,chelation,Iron overloaded
- چکیده:
- چکیده انگلیسی: Objective(s): Nowadays, iron ions intoxication is the center of attention of interest in the management and treatment of thalassemia and different sorts of anemia associated with regular blood transfusions. Due to the major side effects of current drugs, they should be replaced with safer alternatives. Thus, in this study, functionalized hybrid silver nanoparticles, as an emerging perspective, were investigated for absorbing excess iron ions and their removal in an animal thalassemia model. Methods: The silver nanoparticles were green-synthesized using the Myrtus communis leaf methanolic extact (MC-AgNPs). The produced hybrid nano-Sorbents based on hydrolyzable tannin matrix loaded with silver nanoparticles were delivered for trying out in vivo iron chelation in thalassemia model mice in which iron-overload was imposed. MC-AgNPs and desferral were injected intraperitoneally four times a week for one month in mice with excess iron load. The total iron and Fe3+ content of serum was evaluated with the aid of plasma-atomic spectrometry microscopy and a Fe3+ ion measurement kit, respectively. Also, liver enzyme levels were evaluated by an auto-analyzer. Also, hepatic enzyme levels were appraised by using an auto-analyzer based the corresponding kits. Morphological transformations of the liver tissue were investigated by way of Prussian blue staining. Results: The mice treated with the MC-AgNPs demonstrated a significant reduction in serum iron content when compared with the iron-overload mice. MC-AgNPs revealed satisfying effectiveness to chelate excess iron in mice. Conclusions: This method could be considered as a competitive option for lowering the level of excess iron in vivo.
- انتشار مقاله: 06-06-1399
- نویسندگان: Shirin Tavakoli,Mohammad Ali Ebrahimzadeh,Fatemeh Sameni,Pourya Biparva,Hamidreza Mohammadi,Ali Ziar,Afshin Zahedi Mazandarani,Soheil Vafaeinejad,Shahram Eslami
- مشاهده