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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Research Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibacterial,silver nanoparticles,Molecular Dynamics,Euphorbia Pseudocactus Berger (Euphorbiaceae)
- چکیده:
- چکیده انگلیسی: In the present study, silver nanoparticles (Ag NPs) were synthesized by using Euphorbia Pseudocactus Berger (Euphorbiaceae) extract, which played the main role in the formation and stability of nanoparticles. The physic-chemical property of biosynthesized nanoparticles were identified using X-ray diffraction (XRD), Ultraviolet–Visible spectroscopy (UV-Vis), Fourier-Transform Infrared spectroscopy (FT-IR) and Transmission Electron Microscopy (TEM) techniques. UV-Vis results illustrated that maximum plasma resonance absorption of Ag NPs are about 426 nm. Size distribution and spherical morphology was determined by TEM method. The XRD was confirmed face centered cubic (FCC) structure for synthesized nanoparticles.The molecular dynamics (MD) and monte carlo (MC) simulations were used to evaluate the nanoparticles .The antibacterial properties of biosynthesized Ag NPs were studied on E.coli (ATCC 25922), S. aureus (ATCC 2592), P. aeruginosa (ATCC27853) and E. faecalis (ATCC51299) by using micro dilution broth method. The minimum inhibitory concentration (MIC) results of synthesized Ag NPs on S. aureus and E. faecalis obtained 4 and 8 μg/mL and P. aeruginosa and E. coli obtained 16 and 4 μg/mL. So, synthesized nanoparticles can be utilized as an antibacterial agent in medical and industrial devices and tools.
- انتشار مقاله: 07-05-1399
- نویسندگان: Yasin Sadeghipour,Mohammad Hassan Alipour,Hamid Reza Ghaderi Jafarbeigloo,Afsaneh Salahvarzi,Mehdi Mirzaii,Ali Mohammad Amani,Sareh Mosleh-shirazi,Mohsen Mehrabi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Renewable Energy and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: network design,mixed integer linear programming,switchgrass,bioethanol supply chain,Auto-Regressive Moving Average Time Series
- چکیده:
- چکیده انگلیسی: Switchgrass is known as one of the best second-generation lignocellulosic biomasses for bioethanol production. Designing efficient switchgrass-based bioethanol supply chain (SBSC) is an essential requirement for commercializing the bioethanol production from switchgrass. This paper presents a mixed integer linear programming (MILP) model to design SBSC in which bioethanol demand is under auto-regressive moving average (ARMA) time series models. In this paper, how a SBSC design is affected by ARMA time series structure of bioethanol demand is studied. A case study based on North Dakota state in the United States demonstrates application of the proposed approach in designing the optimal SBSC. Moreover, SBSC optimal design is forecasted for the time horizon of 2013 to 2020 with the bioethanol demand acquired from the ARMA models to provide insights for designing and minimizing total cost of SBSC in the future efficiently. Finally, in order to validate the proposed approach, a reproduction behavior test is done. Also, a comparative analysis based on a SBSCND model from the recent literature is elaborated to show the performance of the proposed approach.
- انتشار مقاله: 11-10-1348
- نویسندگان: Hamid Ghaderi,Mona Asadi,Saeed Shavalpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: One major goal of tissue engineering and regenerative medicine is to find an appropriate source of mesenchymal stem cells (MSCs) with higher differentiation ability.Purpose: In this experimental study, the osteogenic and chondrogenic differentiation ability of buccal fat pad derived MSCs (BFP-MSCs) with gingival derived cells (GDCs) were compared.Materials and Method: BFP-MSCs and GDCs were cultured enzymatically and expanded. The expanded cells were analyzed for membrane-associated markers, using flow cytometry. Then the ability of these cells to differentiate into osteocyte and chondrocyte was assessed morphologically and by mRNA expression of collagen I (COLL), BGLA and bone morphogenetic protein 2 (BMP2) using qRT-PCR.Results: Flow cytometry analysis showed that both BFP-MSCs and GDCs expressed the characteristic stem cell markers such as CD73, CD44, and CD90, whereas they did not express hematopoietic markers. Mineralized calcium deposition was observed apparently in BFP-MSCs cultured in osteogenic medium but GDCs showed fewer mineralized nodules. The mRNA expression levels of BGLA and BMP2 showed 7×105 and 733-fold more mRNA expression in BFP-MSCs treated with differentiation media compared to the control group. In chondrogenic differentiation, BFP-MSCs transformed from a spindle to a cuboidal shape while GDCs showed only a slight transformation. In addition, mRNA expression of COLL showed 282-fold higher expression in BFP-MSCs in comparison to the control group. Such significant difference in mRNA expression of BGLA, BMP2, and COLL was not observed in GDCs compared to their corresponding controls.Conclusion: Based on the present results, BFP yields a greater proportion of stem cells compared to gingiva. Therefore, this tissue can be introduced as an easily available source for the treatment of periodontal defects and other maxillofacial injuries.
- انتشار مقاله: 02-10-1395
- نویسندگان: Hamid Ghaderi,Mahboobeh Razmkhah,Farin Kiany,Nooshafarin Chenari,Mohammad Reza Haghshenas,Abbas Ghaderi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Single Nucleotide Polymorphism,Oral lichen planus,programmed cell death protein,Autoimmune Disease
- چکیده:
- چکیده انگلیسی: Background: The association between programmed cell death protein 1 (PD-1) variations and susceptibility to
autoimmune diseases has been recurrently reported. However, there is no report about its relationship with oral lichen
planus (OLP) as one of autoimmune diseases. Methods: We investigated the association between genetic predisposition
to OLP and two single nucleotide polymorphisms in PD-1. Results: GG, GA, and AA genotypes at position +7146
were found in 59 (80.8 %), 10 (13.7 %), and 4 (5.5 %) patients, and in 132 (77 %), 34 (20 %), and 5 (3 %) healthy
participants. CC, CT, and TT genotypes at position +7785 were found in 32 (43.8 %), 35 (47.9 %), and 6 (8.2 %) patients
and in 99 (58 %), 66 (39 %), and 6 (3 %) controls. Analysis indicated that patients’ genotypes were not statistically
different from controls’ genotypes at both positions +7146 (P = 0.35 and P = 0.98) and +7785 (P = 0.07 and P = 0.06).
Conclusion: The findings indicated that PD-1 SNPs at +7146 [PD-1.3] G/A and +7785 [PD-1.5] C/T was not associated
with susceptibility to OLP. However, further research with higher sample size and in different geographical regions is
needed in order to achieve the generalizability of the findings.- انتشار مقاله: 30-10-1396
- نویسندگان: Janan Ghapanchi,Hamid Ghaderi,Mohammad Reza Haghshenas,Samira Jamshidi,Fahimeh Rezazadeh,Azita Azad,Mitra Farzin,Reza Derafshi,Ahmad Hasan Kalantari
- مشاهده