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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Well-controlled clinical studies in the developed world have shown that probiotics can shorten the duration of acute non-bacterial diarrhea. We aimed to evaluate the efficacy of a probiotic consisting of a mixture of Lactobacillus acidophilus and Bifidobacterium bifidum in the treatment of young children with acute diarrhea in Mashad, Iran Methods: Sixty-two hospital inpatients aged 6 to 36 months with acute non-bloody, non-bacterial diarrhea of a less than 2 days' duration and moderate dehydration were enrolled. Thirty-two were treated with probiotic powder three times daily for 5 days plus the routine oral rehydration solution (study group) and the other 30 were given a placebo plus oral rehydration solution (control group). Results: Mean age at the time of admission was 14.5±7 months for the study group and 13.7±6 months for controls. The mean duration of diarrhea was 3.4 days in the study group and 4.5 days in controls (P = 0.027). Duration of hospital admission was 2.1±0.7 days in the probiotic group compared with 2.7±0.6 days in the control group (P = 0.033). Average weight gain was 425 ± 9 and 370 ± 85 g for the study and control groups, respectively. Average reduction in the frequency of diarrhea per day was 4.4 ± 1.5 times for the study group and 3.6 ± 1.3 times for the control group. Conclusion: Lactobacillus acidophilus and Bifidobacterium bifidum shortened the duration of diarrhea and hospital stay, and normalized stool frequency. The use of probiotics might be recommended for treating acute diarrhea in young children.
- انتشار مقاله: 28-02-1394
- نویسندگان: Hamid Reza Kianifar,Reza Farid,Hamid Ahanchian,Farahzad Jabbari,Toktam Moghiman,Armin Sistanian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Pneumonia,Cyanosis-Tachypnea,Zinc sulfate
- چکیده:
- چکیده انگلیسی:
Background: Acute respiratory infections and especially pneumonia are considered as the most important infection-induced cause of child mortality in developing countries. We aimed to investigate the effect of prescribing zinc sulfate on improving the clinical symptoms of pneumonia in 2-59-month-old children.
Materials and Methods: This clinical trial study was performed on 108 children complaining of fever, coughs, and tachypnea referring to three educational hospitals of Mashhad (Ghaem, Imam Reza, and Dr. Sheikh). The patients were randomly assigned into control (n=54), and intervention (n=54). In the control group placebo was prescribed, while the intervention group received oral zinc sulfate 10 mg (1 ml/ kg in children younger than one year, and 20 mg/kg for children above one year every 12 hours. During hospitalization, every 12 hours the clinical symptoms of both groups including tachypnea, duration of fever, coughs, intercostal retraction, hypoxia, crackles-wheezing, and duration of hospitalization were recorded. At the beginning and end of the treatment, two blood samples were taken for determining the serum level of zinc.
Results: The findings indicated that the serum level of zinc sulfate after the intervention increased significantly in the intervention group (p <0.001). There was a significant difference in the duration of fever between the intervention and control groups 24 hours after hospitalization (p=0.014) and 36 hours post-hospitalization (p=0.02). Comparing the presence or absence of tachypnea in the intervention and control groups, there was a significant difference at 36 hours post-hospitalization (p=0.02).
Conclusion: Based on the results, zinc supplement was effective for patients with pneumonia in reducing the duration of fever and number of breaths, but it had no significant effect on the duration of coughs and hospitalization.- انتشار مقاله: 02-02-1399
- نویسندگان: Farhad Heydarian,Mona Nasiri,Ali Reza Attaei Nakhaie,Hamid Ahanchian,Somayeh Ghahremani,Ali Haghbin,Sarah Ghahremani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Vitamin C,Asthma
- چکیده:
- چکیده انگلیسی: Background
Asthma is the most common chronic airway disease in children. We aimed to investigate the effect of vitamin C supplementation on improving the asthma symptoms in children.
Materials and Methods: In a double-blind clinical trial: sixty 2-12-year-old children hospitalized with the diagnosis of asthma attack in the Ghaem and Dr. Sheikh hospitals, Mashhad, Iran were randomly assigned into two groups: intervention (receiving vitamin C tablets 500 mg every 12 hours, n=29), and control (receiving placebo, n=31). In each group, at the beginning and end of the hospitalization, one blood sample (3ml) was taken to evaluate the serum level of vitamin C and for other necessary tests. A pediatric resident recorded clinical symptoms at the beginning and every 6 hours until discharged including tachypnea, wheezing, retraction, and hypoxia every six hours until discharge from the hospital. Eventually, the data in the two groups were compared.
Results: The mean age of the hospitalized patients was 33±24 months. There was a significant difference between the intervention and control groups regarding the serum level of vitamin C at the beginning of hospitalization and at the time of discharge. A significant difference was found in tachypnea of the hospitalized patients of both groups at 24, and 36 hours post hospitalization. Existence of wheezing in the patients of the intervention and control groups had a significant difference at 18, 36, and 66 hours post-hospitalization (p <0.05).
Conclusion
According to the results, oral vitamin C prescription in patients with acute asthma symptoms leads to improved respiratory status (tachypnea and wheezing) in 2-12-year-old children. Also, it is effective in reducing the duration of hospitalization of these children.- انتشار مقاله: 24-01-1399
- نویسندگان: Farhad Heydarian,Alireza Ataei Nakhaei,Sara Ghahremani,Hamid Ahanchian,Somayeh Ghhremani,Saeed Ebrahimi,Mona Nasiri
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,Probiotics,Asthma
- چکیده:
- چکیده انگلیسی: Background: Asthma is a growing problem worldwide and the limitations of the current therapy for allergic asthma highlight the need for novel therapeutics. We conducted a systematic review and meta-analysis to find out the role of probiotics in the treatment of Asthma.
Materials and Methods: In this systematic review, a comprehensive search of the major electronic databases was done till October 2017. Clinical trials comparing the effect of probiotics versus placebo on treating asthma were included. Trials focusing on prevention of asthma were not included. A predefined set of outcome measures was assessed. Continuous data were expressed as standardized mean difference with 95% confidence interval (CI). Dichotomous data were expressed as odds ratio with 95% CI. P-value < 0.05 was considered as significant.
Results: 11 studies with 2,027 participants were included. Probiotic intake was associated with a significant improvement in pulmonary function test and slight benefits in asthma control test. Probiotics did not reduce asthma exacerbation and wheezing episodes although there was a high degree of heterogeneity in studies. It also has no significant effect on viral respiratory infection in asthmatics and no improvement in quality of life. Probiotic intake improved the following parameters: longer time free from episodes of asthma. Adverse events were not significant.
Conclusion: Although trials showed promising effects of probiotics as an additive on therapy on some parameters of asthma, as this evidence was generated from only a few trials with high degree of heterogeneity, routine use of probiotics as an additive on therapy of asthmatic patients cannot be recommended at this time.- انتشار مقاله: 14-09-1397
- نویسندگان: Hamid Ahanchian,Fatemeh Khorasani,Mohammad Ali Kiani,Maryam Khalesi,Elham Ansari,Seyed Ali Jafari,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Probiotics,Allergic Rhinitis,Synbiotics,Subcutaneous allergen immunotherapy
- چکیده:
- چکیده انگلیسی: Background: Synbiotics have been used in the prevention and treatment of various immunological diseases. We aimed to investigate the synergistic clinical and immunologic effects of synbiotics and subcutaneous allergen immunotherapy (SCIT) combination in patients with allergic rhinitis.
Materials and Methods: Nineteen individuals with allergic rhinitis were enrolled in this single blind, placebo-controlled trial between 2015 and 2016 in Qaem Hospital, Mashhad, Iran. Patients were randomly divided into two groups: A) Immunotherapy plus one synbiotic capsule per day, and B) Immunotherapy plus placebo for two months. The Sino-nasal outcome test (SNOT-22), and mini rhinoconjunctivitis quality of life questionnaire (RQLQ) were filled by patients or their parents while intracellular expression of interlukin-4 (IL-4), interferon-gamma (IFN-gamma), and Forkhead Box P3 (FOXP3), and variations in the T helper 1 (Th1), T helper 2 (Th2) and T regulatory cells and cytotoxic T lymphocytes (CTL) frequency were examined by flow cytometry assay at baseline, after 2 and 6 months of intervention.
Results: Nineteen individuals with allergic rhinitis aged between 5 and 55 years participated in this study. No significant difference in the frequency of symptoms between the two groups was observed after 2 and 6 months of intervention (p>0.05). A significant increase in the percentage of Th1 cells was recorded in group A compared to group B (p= 0.02). CTL enhancement percentage was significantly increased in group A compared to group B after 2 months (p=0.013).
Conclusion: Subcutaneous Immunotherapy concomitant with synbiotics administration may have temporarily increased the percentage of Th1 cells, but no significant clinical differences were observed.- انتشار مقاله: 29-02-1398
- نویسندگان: Nasrin Moazzen,Hamid Ahanchian,Farahzad Jabbari Azad,Mojgan Mohammadi,Reza Farid,Amin Reza Nikpoor,Maryam Salehi,Maryma Khoshkhui
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Spirometry,Asthma,Child,Selective exercise program
- چکیده:
- چکیده انگلیسی: Background
Physical activity in asthmatic children may be useful. But there is not adequate knowledge about it. In present study the effect of selective exercise on motor competency and pulmonary function in asthmatic pediatrics was evaluated.
Materials and Methods
In a randomized clinical trial study,fifteen asthmatic children aged 6 to 18 years were included. Patients were randomly divided into the experimental or control group. There was no difference in the routine pharmacotherapy. The aerobic group had an exercise program consisting of 45-minute sessions three times per week for 8 weeks. The outcome measures were the difference between the pre- and post-exercise program and also the experimental and control groups. Spirometry parameters (such as FEV1and FVC) were measured. Motor competency was measured by the Ozeretski test. Quality of life was evaluated by St. George's questionnaire. The data were analyzed using SPSS software (version 16.0).
Results: A significant effect was observed for spirometry parameters, quality of life and the Ozeretski test in two studied groups. Aerobic exercise had a significant effect in improving FEF 25-75%, quality of life and the fine and gross motor performance in the experimental group (P< 0.05). A significant difference was observed between two groups for FEF, FEF25-75% and quality of life (P< 0.05).
Conclusion
Regular exercise improves the spirometric parameters and quality of life in studied asthmatic children. In present study, aerobic exercise and strength training were useful complementary means for the treatment of asthmatic children.- انتشار مقاله: 08-10-1397
- نویسندگان: Ezzat Khodashenas,Elham Bakhtiari,Mehdi Sohrabi,Ali Mozayani,Manijheh Arabi,Vahideh Valayati Haghighi,Nasrinsadat Motevalli Haghi,Hamid Ahanchian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Probiotics,Pediatrics,Diarrhea,Yogurt consumption
- چکیده:
- چکیده انگلیسی: Background
The popularity of probiotics is on the rise. Despite the beneficial effects of antibiotics, gastrointestinal health is at risk of diarrhea. This study aimed to investigate whether probiotic yogurt is of capability to prevent the incidence of diarrhea versus conventional yogurt.
Materials and Methods
This controlled, randomized, double-blind trial was designed to recruit 48 hospitalized children, whose treatments included different types of antibiotics. They were subsequently assigned into a 1:1 ratio into groups A and B at random. The first group was instructed to consume probiotic yogurt (Bifidobacterium strains and Lactobacillus acidophilus), while the second were on conventional yogurt (placebo containing Streptococcus thermophiles and Lactobacillus bulgaricus) at least for 7 days. The incidence of diarrhea, its onset and duration were compared between the two groups.
Results
The findings indicated that there was no statistically significant difference between the experimental and control groups (p > 0.05). No significant decrease was observed in the incidence of diarrhea between the groups following adjustment for negative C-reactive protein (CRP) (p > 0.05).
Conclusion
According to the results, the consumption of yogurt, either probiotic or conventional, reduced the incidence, duration, and onset of antibiotic-associated diarrhea in pediatric population. This study showed no significantly better performance for probiotic yogurt than conventional yogurt.- انتشار مقاله: 25-07-1396
- نویسندگان: Majid Khademian,Mohammad Ali Kiani,Seyed Ali Jafari,Hamid Ahanchian,Niloofar Sedghi,Fatemeh Behmanesh,Ali Khakshour,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Cystic fibrosis,Dermatglyphics,Palm patterns,Asymmetry a-b ridge count,ATD angel
- چکیده:
- چکیده انگلیسی: Background
Dermatoglyphics could assist in the diagnosis of congenital abnormalities. The aim of this study was to identify the dermatoglyphic patterns (finger print pattern type, total ridge count of each finger, a-b ridge count, and articulotrochanteric distance [ATD angles]) in the parents of cystic fibrosis children.
Materials and Methods
We recruited 75 parents of children with cystic fibrosis for the study group and 341 parents for the control group. We recorded finger print pattern type, total ridge count (TRC), a-b ridge count, and ATD angles of all participants. Then we identified any asymmetry between the right and left hands of each person and characteristics of parents in two genders. Chi-square analysis, Mann-Whitney U test, and Fisher's exact test were used for data analysis.
Results
We observed significant differences in a-b ridge count on the right hand (P=0.02), and mean total ridge count on the right digit I (P=0.05), right digit IV (P=0.03), and right digit V in the fathers of children with cystic fibrosis compared to the control group(P=0.02).
Conclusion
According to the results, we suggest that the dermatoglyphic traits of parents could be used as a simple, appropriate, and supplementary screening method in the diagnosis of children with CF. Nevertheless, we need lager studies to precisely confirm that dermatoglyphics is a reliable method in the diagnosis of CF.- انتشار مقاله: 05-05-1396
- نویسندگان: Hamid Reza Kianifar,Atefeh Ezzati,Seyed Ali Jafari,Mohammad Ali Kiani,Hamid Ahanchian,Hasan Karami,Ezzat Khodashenas,Arezoo Jahanbin
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: neonate,NICU,Portal vein thrombosis (PVT),Umbilical catheterization
- چکیده:
- چکیده انگلیسی: Background
Portal vein thrombosis (PVT) is one of the most common causes of extrahepatic portal hypertension in children, which may follow neonatal umbilical vein catheterization. The incidence rates of catheter-related PVT, in infants and children vary in different studies. This study aimed to determine PVT incidence in the children under 3 years old with a history of neonatal umbilical vein catheterization in the NICU of Ghaem Hospital, Mashhad- Iran.
Materials and Methods
This cross-sectional study included 38 children with a history of hospitalization in the NICU of Ghaem Hospital, Mashhad-Iran, during 2012 to 2013 for whom umbilical vein catheterization had been performed. The Children’s histories were taken and they were examined. Color Doppler ultrasound was performed on them. Data analysis was carried out using SPSS-13 and descriptive statistics, t-test, Fisher's exact test.
Results
Fourteen (36.8%) and 24 (63.2%) of the infants were males and females, respectively. Mean age of the infants was 33.1±3.55 months. PVT evidence in a child raises a 2.6% PVT incidence. No statistically significant relationship was observed among gender, age, catheter type, and catheterization duration and PVT. A statistically significant relationship was observed between spleen size and portal vein size in ultrasound and PVT (P<0.05). The liver and spleen examination was only abnormal, in the patient with thrombosis.
Conclusion
The study findings suggest a 2.6% incidence for PVT. In addition, neonatal umbilical catheterization causes PVT during childhood.- انتشار مقاله: 05-06-1395
- نویسندگان: Gholamali Maamouri,Seyed Javad Sayedi,Behrooz Davachi,Mohammad Ali Kiani,Hamid Ahanchian,Lida Jarahi,Maryam Zakerhamidi,Hassan Boskabadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Valproic acid,Liver failure,Liver transaminases
- چکیده:
- چکیده انگلیسی: Introduction
Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other
antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity.
The aim of this study was to investigate valproic acid impact on liver transaminases
at the beginning of VPA treatment and after three and six months of it.
Materials and Methods
This study was designed as a cross sectional project in Pediatrics Neurology
ward of a Tertiary Academic Hospital (Ghaem Hospital, Mashhad-Northeastern
Iran). All children who needed valproic acid therapy alone were selected for study.
Liver function test was performed for them at the beginning of VPA administration,
three and six months after VPA, respectively. Data was analyzed by SPSS version 16.
Results
60 children with mean age of 49±28.6 months were entered the study.
37 of them were male and 23 were female. 5% (3 children) were mental retard
and 11.7% (7 patients) had neurologic or developmental deficit. Mean value of
Aspartate Aminotransferase (AST), Alanine Transferase (ALT) and Alkaline
phosphatase (ALP) were 27, 30.8 and 30.4 and 17.4, 20.7 and 22.8 and 425,
426 and 441 at the beginning of VPA administration, three and six months after
VPA, respectively. In six months of our follow up, only one child (1.7%) had elevated
liver transaminases.
Conclusion
Regard to our findings and its agreement with previous researches, it is important to
control adverse drug events by measuring liver transaminases during antiepilepsy treatment.- انتشار مقاله: 20-01-1394
- نویسندگان: Javad Akhondian,Mohammad Ali Kiani,Seyed Ali Jafari,Mehran Beiraghi Toosi,Mansoureh Mirzaei Najm Abad,Hamid Ahanchian,Hamidreza Kianifar
- مشاهده