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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Breast cancer,Kerman,Human papilloma virus
- چکیده:
- چکیده انگلیسی: Breast cancer is the first of the most important causes of the deaths of women in the world and in Iran. There are
various causes and causes of this cancer, one of which has recently been described as a cause of breast cancer, is the human
papillomavirus (HPV). The HPV is transmitted through sexual contact and skin lesions. There are more than 100 types of
HPV that can influence different parts of the body. Some types of HPV can cause cancer (such as cervical or anal cancer)
and others can cause warts (such as genital or plantar warts). To study the risk of HPV infection in Breast Cancer, we
managed a Case-Control study in Kerman, southeast of Iran. For this purpose, 98 paraffin blocks of breast cancer and
40 paraffin blocks of fibrocystic as a control were tested for the presence of HPV DNA using Real-Time PCR, and
HPV typing was done using INNo-Lippa assay. HPV DNA was detected in 8 out of 98 patients (8.2%), while it was
not detected in the control group samples. HPV types 16, 18 were the most common (62.5%) types in positive samples.
The prevalence of HPV in patients with breast cancer of Iran is very low and less than other regions of the world,
it seems that maybe rout of transmission of HPV in Iran is under control. No one knows exactly why breast cancer
occurs. The environment, hormones, Viruses, or your lifestyle could all play a role in the development of breast cancer.
Currently, Vaccination is the best way to prevent cancer that’s due to HPV. However, additional studies on the larger
group of patients are needed to explain the roles of HPV in Breast cancer.- انتشار مقاله: 03-07-1396
- نویسندگان: Reza Malekpour Afshar,Negin Balar,Hamid Reza Mollaei,Seyed Alimohammad Arabzadeh,Maryam Iranpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,HPV,Real Time PCR,HPV Genotype
- چکیده:
- چکیده انگلیسی:
Background: The HPV virus is known to be oncogenic and associations with many cancers has been proven. Although many studies have been conducted on the possible relationship with colorectal cancer (CRC), a definitive role of the virus has yet to be identified. Method: In this cross-sectional study, the frequency of HPV positivity in CRC samples in Kerman was assessed in 84 cases with a mean age of 47.7 ± 12.5 years over two years. Qualitative real time PCR was performed using general primers for the L1 region of HPV DNA. Results: Out of 84 CRC samples, 19 (22.6%), proved positive for HPV DNA. Genotyping of positive samples showed all of these to be of high risk HPV type. Prevalence of HPV infection appears to depend geographic region, life style, diet and other factors. Conclusion: In our location frequency of CRC is low, and this limited the sample size for evaluation of HPV DNA. The most prevalent types were HPV types 51 and 56. While HPV infection may play an important role in colorectal carcinogenesis, this needs to be assessed in future studies.- انتشار مقاله: 11-07-1396
- نویسندگان: Reza Malekpour Afshar,Zeinab Deldar,Hamid Reza Mollaei,Seyed Alimohammad Arabzadeh,Maryam Iranpour
- مشاهده