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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Analytical Hierarchy Process,Industrial waste,Landfill siting
- چکیده:
- چکیده انگلیسی: Locating landfills in urban areas is one of the most important issues in urban planning because of the effect on economy, ecology, and environment, therefore the right management and principled landfilling of solid waste is the major concern all over the world especially in the developed countries. In locating landfills, different criteria should be considered. In the present study, locating sites for solid landfill of two industrial suburbs in Natanz using Analytic Hierarchy Process (AHP) was investigated so as to present optimal solutions. Three places were investigated as suggested sites and seven factors like distance from the industrial suburb, ease of access, cost of site preparation, access to covering soil, wind direction, soil penetration, and groundwater direction were considered in the decision-making process. Super Decisions software was mployed to create hierarchy network, compare criteria and sub criteria, and finally choose better choice. Based on the results, the third choice located in northeast of Shojaabad suburb and southeast of Ooreh suburb (almost between two suburbs) was selected as the best choice to bury the industrial wastes of these suburbs with score of 0.618 based on the software results. The incompatibility rate was 0.069.
- انتشار مقاله: 01-08-1395
- نویسندگان: Majid Hashemi,Hamid Reza Pourzamani,Saeed Fadaei,Faezeh Heidari,Golnaz Safa,Iman Parseh,Hamed Mohammadi,Saeed Parastar
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advances in Environmental Health Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Analytical Hierarchy Process,Industrial waste,Landfill siting
- چکیده:
- چکیده انگلیسی: Locating landfills in urban areas is one of the most important issues in urban planning because of the effect on economy, ecology, and environment, therefore the right management and principled landfilling of solid waste is the major concern all over the world especially in the developed countries. In locating landfills, different criteria should be considered. In the present study, locating sites for solid landfill of two industrial suburbs in Natanz using Analytic Hierarchy Process (AHP) was investigated so as to present optimal solutions. Three places were investigated as suggested sites and seven factors like distance from the industrial suburb, ease of access, cost of site preparation, access to covering soil, wind direction, soil penetration, and groundwater direction were considered in the decision-making process. Super Decisions software was mployed to create hierarchy network, compare criteria and sub criteria, and finally choose better choice. Based on the results, the third choice located in northeast of Shojaabad suburb and southeast of Ooreh suburb (almost between two suburbs) was selected as the best choice to bury the industrial wastes of these suburbs with score of 0.618 based on the software results. The incompatibility rate was 0.069.
- انتشار مقاله: 01-08-1395
- نویسندگان: Majid Hashemi,Hamid Reza Pourzamani,Saeed Fadaei,Faezeh Heidari,Golnaz Safa,Iman Parseh,Hamed Mohammadi,Saeed Parastar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Hospitalization,Caregivers,mental disorders,Case-Management
- چکیده:
- چکیده انگلیسی: Background: Providing community-based mental health services is crucial and is an agreed plan between the Iranian Mental Health Office and the Regional Committee for the Eastern Mediterranean (affiliated with WHO). The aim of this study was to determine the effectiveness of home-visit clinical case-management services on the hospitalization rate and other clinical outcomes in patients with severe mental illness.Methods: A total of 182 patients were randomly allocated into three groups, namely, home-visit (n=60), telephone follow-up (n=61) and as-usual care (n=61) groups. Trained nurses as clinical case-managers provided home-visit services and the telephone follow-up tasks. Hospitalization rate as a measure of recurrence, as well as burden, knowledge, general health condition of caregivers with positive/negative symptoms, satisfaction, quality of life, and social skills of the consumers were assessed as the main and secondary outcomes, respectively.Results: Most clinical variables were improved in both intervention groups compared with the control group. During the one year follow-up, the rate of rehospitalization for the telephone follow-up and as-usual groups were respectively 1.5 and 2.5 times higher than the home-visit group.Conclusion: Trained clinical case-managers are capable of providing continuous care services to patients with severe mental illness. The telephone follow-up services could also have beneficiary outcome for the consumers, their caregivers, and the health system network.
- انتشار مقاله: 16-09-1392
- نویسندگان: Seyed Kazem Malakouti,Marzieh Nojomi,Arash Mirabzadeh,Yasaman Mottaghipour,Alireza Zahiroddin,Hamed Mohammadi Kangrani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Monoclonal antibody,"a" Determinant,HBs Ag
- چکیده:
- چکیده انگلیسی: Background: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect the performance of HBsAg assays.
Objectives: To construct clinically relevant recombinant mutant forms of HBsAg and assessment of their reactivity with anti-HBs monoclonal antibodies (MAbs).
Methods: Wild type (wt) and mutant (mt) HBsAg genes were constructed by site directed mutagenesis and SEOing PCR. The amplified genes were inserted into pCMV6-neo plasmid and transfected in CHO cell line. The expression of wt- and mtHBsAg was assessed by commercial ELISA assays and stable cells were established and cloned by limiting dilution. The recombinant mutants were further characterized using a panel of anti-HBs monoclonal antibodies (MAbs) and the pattern of their reactivity was assessed by ELISA.
Results: Ten HBsAg mutants having single mutation within the "a" determinant including P120E, T123N, Q129H, M133L, K141E, P142S, D144A, G145R, N146S and C147S together with a wt form were successfully constructed and expressed in CHO cells. Reactivity of anti-HBs MAbs with mtHBsAgs displayed different patterns. The effect of mutations on antibody binding differed depending on the amino acid involved and its location within the ‘‘a’’ determinant. Mutation at amino acids 123 and 145 resulted in either complete loss or significant reduction of binding to all anti-HBs MAbs.
Conclusion: Our panel of mtHBsAgs is a valuable tool for assessment of the antibody response to HBV escape mutants and may have substantial implications in HBV immunological diagnostics.- انتشار مقاله: 15-05-1395
- نویسندگان: Forough Golsaz Shirazi,Mohammad Mehdi Amiri,Hamed Mohammadi,Ali Ahmad Bayat,Azam Roohi,Jalal Khoshnoodi,Amir Hassan Zarnani,Mahmood Jeddi-Tehrani,Gholam Ali Kardar,Fazel Shokri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Finance
- نوع مقاله: Journal Article
- کلمات کلیدی: Strategic Management Accounting Techniques,Consequences of Green Accounting,Analysis CARD,Developed Theory of Rough
- چکیده:
- چکیده انگلیسی: Strategic management accounting, including systems and processes in the modern era, is characterized by changes in the competitive environment that, Can be achieved through the participation of companies in the management accounting system, Assist financial managers to make decisions in the value chain and develop green accounting functions. Unfortunately, though, over time, strategic management accounting techniques are still unknown to corporate executives, especially in environmental processes, leading to a decline in corporate participation in strategic decision making. The Purpose of this research is Capacity Building Green Accounting Consequences Based on Explanation of Strategic Management Accounting Techniques by analysis of CARD and developed the theory of Rough (ERST). The methodology of this research is developmental, applied and hybrid and two groups of target population participated in this research. In the first part of 15 experts in the field of accounting at the university level an In the second part, 35 executives participated matrix Tehran Stock Exchange through a questionnaire that both the target population, sampling was homogenous. In this research, in the qualitative part, the components and indices related to the research variables were selected based on content analysis and cross-analysis and then based on Delphi analysis and hierarchical analysis in order to achieve theoretical adequacy. Then, in the quantitative section, through the analysis of the Rough Complex analysis, the decision tree determined the most effective green accounting function/outcome and strategic management accounting technique, and finally, the product life cycle costing technique is the most effective strategic management accounting technique for enhancing green accounting functions. In fact, the results showed that product cycle costing technique is a factor for enhancing the cost savings of recycling and waste recycling costs and increasing the competitiveness of the company as a component of green accounting competitive Consequences.
- انتشار مقاله: 25-01-1399
- نویسندگان: Behjat Abbasi,Mohammadhamed Khanmohammadi,Zahra Moradi,Tahereh Mahmoodiyan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Finance
- نوع مقاله: Journal Article
- کلمات کلیدی: inflation,Earnings Management,political connections,Economic Indicators
- چکیده:
- چکیده انگلیسی: Governments always affect the economic environment as legislators in the field of business. The economic conditions governing the market and business require different conditions and contexts for decision making and corporate execution practices. Companies and managers administering them under environmental conditions, achieve their goals by employing various earnings management methods. Hence, the present study examines the effect of governments’ economic performance on the earnings management methods used in listed companies of Tehran Stock Exchange (2004-2016) for a sample of 16 industries and 271 companies. To test the hypotheses, multivariate regression model was used. The results showed that during the research period, companies managed earnings, and while more than 70% of companies used the accrual earnings management method, there was a relationship between annual economic indicators and real earnings management, and the change in general level of prices and the political connections of states have affected the relationship. Also, the accruals-based earnings management method occurred independent of annual economic indicators and there is a significant relationship between governments changes and earnings management methods.
- انتشار مقاله: 11-10-1348
- نویسندگان: Alireza Ghonji Feshki,Mohammad Hamed Khanmohammadi,Shohreh Yazdani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Insulin,Meta-Analysis,Gene Therapy,Type 1 Diabetes Mellitus,Non-viral vector,Viral vector
- چکیده:
- چکیده انگلیسی: Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, and insulin in animals with type 1 DM.
Materials and Methods: The Cochrane Library, PubMed, Embase, ISI Web of Science, SCOPUS, and Google Scholar were systematically searched for potentially relevant studies. Mean±standard deviation (SD) was pooled using a random-effects model.
Results: After the primary search, out of 528 studies identified, 16 studies were in concordance with predefined criteria and selected for the final assessment. Of these, 12 studies used viral manipulation, and 4 employed non-viral vectors for gene delivery. The meta-analysis showed gene therapy with a viral vector decreased mean IPGTT (-12.69 mmol/l, P<0.001), fasting blood glucose (-13.51 mmol/l, P<0.001), insulin (398.28 pmol/l, P<0.001), and bodyweight (24.22 g, P<0.001), whereas non-viral vectors reduced fasting glucose (-29.95 mmol/l, P<0.001) and elevated insulin (114.92 pmol/l, P<0.001).
Conclusion: Gene therapy has favorable effects on alleviating type 1 DM related factors in diabetic rodents.- انتشار مقاله: 20-01-1398
- نویسندگان: Moosa Rahimi Ghiasi,Hamed Mohammadi,Michael Symonds,Seyed Mohammad Bagher Tabei,Ahmad Reza Salehi,Sima Jafarpour,Leila Norouzi Barough,Elnaz Rahimi,Zohreh Amirkhani,Maryam Miraghajani,Rasoul Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Vitamin D,CREB,Brain-derived neurotrophic factor,TrkB
- چکیده:
- چکیده انگلیسی: Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory. BDNF exerts its functions via tropomyosin receptor kinase B (TrkB). BDNF transcription is regulated by stimulating CREB phosphorylation. The CREB-TrkB-BDNF pathway is reported to be affected by diabetes, which may contribute to its cognitive deficits. This study was conducted to investigate the effect of vitamin D supplementation on the hippocampal fraction of this pathway in an animal model of type-1 diabetes mellitus (T1DM).
Materials and Methods: Thirty-six adult male Sprague-Dawley rats were randomly divided into 4 groups as follows: Group 1: normal healthy rats (n=8); group 2: normal healthy rats receiving sesame oil supplementation as placebo (n=8); Group 3: diabetic rats receiving sesame oil (n=10); and Group 4: diabetic rats treated with 4300 IU/kg/week vitamin D dissolved in sesame oil (n=10). Diabetes was induced by intraperitoneal (IP) injection of streptozotocin. Blood and hippocampal samples were acquired at the end of the experiment. RNA was extracted from the hippocampus, and real-time PCR (polymerase chain reaction) was performed for BDNF and TrkB gene expression.
Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.
Conclusion: Vitamin D increased hippocampal CREB phosphorylation in a T1DM animal model. Our findings showed that vitamin D might be protective against central nervous system complications in diabetes. However, future studies are warranted.- انتشار مقاله: 13-11-1397
- نویسندگان: Hoda Nadimi,Abolghassem Djazayery,Mohammad Hassan Javanbakht,Ahmadreza Dehpour,Ehsan Ghaedi,Hoda Derakhshanian,Hamed Mohammadi,Seyedeh Neda Mousavi,Mahmoud Djalali
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Insulin,Meta-Analysis,Gene Therapy,Type 1 Diabetes Mellitus,Non-viral vector,Viral vector
- چکیده:
- چکیده انگلیسی: Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, and insulin in animals with type 1 DM.
Materials and Methods: The Cochrane Library, PubMed, Embase, ISI Web of Science, SCOPUS, and Google Scholar were systematically searched for potentially relevant studies. Mean±standard deviation (SD) was pooled using a random-effects model.
Results: After the primary search, out of 528 studies identified, 16 studies were in concordance with predefined criteria and selected for the final assessment. Of these, 12 studies used viral manipulation, and 4 employed non-viral vectors for gene delivery. The meta-analysis showed gene therapy with a viral vector decreased mean IPGTT (-12.69 mmol/l, P<0.001), fasting blood glucose (-13.51 mmol/l, P<0.001), insulin (398.28 pmol/l, P<0.001), and bodyweight (24.22 g, P<0.001), whereas non-viral vectors reduced fasting glucose (-29.95 mmol/l, P<0.001) and elevated insulin (114.92 pmol/l, P<0.001).
Conclusion: Gene therapy has favorable effects on alleviating type 1 DM related factors in diabetic rodents.- انتشار مقاله: 20-01-1398
- نویسندگان: Moosa Rahimi Ghiasi,Hamed Mohammadi,Michael Symonds,Seyed Mohammad Bagher Tabei,Ahmad Reza Salehi,Sima Jafarpour,Leila Norouzi Barough,Elnaz Rahimi,Zohreh Amirkhani,Maryam Miraghajani,Rasoul Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Vitamin D,CREB,Brain-derived neurotrophic factor,TrkB
- چکیده:
- چکیده انگلیسی: Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory. BDNF exerts its functions via tropomyosin receptor kinase B (TrkB). BDNF transcription is regulated by stimulating CREB phosphorylation. The CREB-TrkB-BDNF pathway is reported to be affected by diabetes, which may contribute to its cognitive deficits. This study was conducted to investigate the effect of vitamin D supplementation on the hippocampal fraction of this pathway in an animal model of type-1 diabetes mellitus (T1DM).
Materials and Methods: Thirty-six adult male Sprague-Dawley rats were randomly divided into 4 groups as follows: Group 1: normal healthy rats (n=8); group 2: normal healthy rats receiving sesame oil supplementation as placebo (n=8); Group 3: diabetic rats receiving sesame oil (n=10); and Group 4: diabetic rats treated with 4300 IU/kg/week vitamin D dissolved in sesame oil (n=10). Diabetes was induced by intraperitoneal (IP) injection of streptozotocin. Blood and hippocampal samples were acquired at the end of the experiment. RNA was extracted from the hippocampus, and real-time PCR (polymerase chain reaction) was performed for BDNF and TrkB gene expression.
Results: Administration of vitamin D (4300 IU/kg/week) in a T1DM animal model increased CREB phosphorylation in the hippocampus, but the serum and hippocampal BDNF levels and TrkB and BDNF gene expression did not change significantly.
Conclusion: Vitamin D increased hippocampal CREB phosphorylation in a T1DM animal model. Our findings showed that vitamin D might be protective against central nervous system complications in diabetes. However, future studies are warranted.- انتشار مقاله: 13-11-1397
- نویسندگان: Hoda Nadimi,Abolghassem Djazayery,Mohammad Hassan Javanbakht,Ahmadreza Dehpour,Ehsan Ghaedi,Hoda Derakhshanian,Hamed Mohammadi,Seyedeh Neda Mousavi,Mahmoud Djalali
- مشاهده