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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Nanoparticles,Cytotoxicity,biocompatibility,Aluminium Nitride
- چکیده:
- چکیده انگلیسی: Objective(s): Aluminium nitride (AlN) could be used in implantable biomedical sensor devices, for which cytotoxicity analysis is of utmost importance.
Materials and Methods: AlN nanoparticles were synthesized using a simple and effective solvothermal method. The X-ray diffraction results revealed the cubic phase of AlN, and the field emission scanning electron microscopy analysis demonstrated the structural morphology of the synthesized materials. In addition, the cytotoxicity of the AlN nanoparticles was assessed against healthy (HEK-293, HUVEC, and MCF10A) and cancerous cell line (HeLa). The intensity of the reactive oxygen species was also measured to determine the induced oxidative stress in the treated cells.
Results: The cytotoxicity analysis indicated that the AlN nanoparticles were nontoxic against the cancerous and normal cell lines. No significant changes were observed between the low doses of the AlN nanoparticles in the treated and control cells. However, morphological changes were detected by a phase contrast microscope, while insignificant changes were observed similar to the control cells.
Conclusion: The findings of this study could lay the groundwork for the development of AlN nanoparticles for further biomedical applications.- انتشار مقاله: 22-02-1399
- نویسندگان: Manjot Kaur,Kulwinder Singh,Paviter Singh,Amanpreet Kaur,Ramovatar Meena,Gajendra Pratap Singh,Hamed Barabadi,Muthupandian Saravanan,Akshay Kumar
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibacterial activity,Biosynthesis,selenium nanoparticles,Nanobiotechnology
- چکیده:
- چکیده انگلیسی: Objective(s): This study deals with mycosynthesis and characterization of selenium nanoparticles (SeNPs) using the Penicillium chrysogenum PTCC 5031 and evaluating their antibacterial activity.
Materials and Methods: The formation of SeNPs was confirmed with the color change from pale yellow to orange. Tyndall effect also confirmed the formation of colloidal systems through the samples. The SeNPs were characterized using different analytical techniques including photon correlation spectroscopy (PCS), Scanning Electron Microscope (SEM), Atomic Force Microscope (AFM), Energy Dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier Transform Infrared (FT-IR) analysis.
Results: Our findings revealed that SeNPs were fairly uniformed with good monodispersity and the lesser aggregation of particles in pH value of 7 with the average hydrodynamic size of 24.65 nm, polydispersity index (PdI) of 0.392 and zeta potential of -34 mV. The SeNPs revealed antibacterial activity against gram positive bacteria including Staphylococcus aureus, and Listeria monocytogenes with the zone of inhibition (ZOI) of 10 and 13 mm, respectively.
Conclusion: The results of this study provided a potential solution to the growing need for the development of cost-effective and eco-friendly ways of nanoparticle synthesis to overcome the microbial resistance and control the infectious diseases. However, further investigations are required to demonstrate the efficacy of SeNPs through in vivo models.- انتشار مقاله: 02-07-1399
- نویسندگان: Hossein Vahidi,Farzad Kobarfard,Zahra Kosar,Mohammad Ali Mahjoub,Muthupandian Saravanan,Hamed Barabadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Antimicrobial,Zinc oxide nanoparticles,Cytotoxicity
- چکیده:
- چکیده انگلیسی: Objective(s): This study was aimed to investigate the synthesis of novel zinc oxide (ZnO) nanoparticles (NPs) using Solanum trilobatum leaf extract as the reducing and capping agents, called green synthesized zinc oxide nanoparticles (GS-ZnONPs).
Materials and Methods: Chemically synthesized zinc oxide nanoparticles (CS-ZnONPs) were synthesized using precipitation method with zinc nitrates hexahydrate as reducing precursors. The synthesized GS- and CS-ZnONPs were examined and characterized using UV-visible spectroscopy, Transmission Electron Microscopy (TEM), Scanning Electron microscopy (SEM), Energy dispersive X-ray analysis (EDAX), and X-ray diffraction (XRD) analysis, respectively.
Results: GS-ZnONPs exhibited a higher zone of inhibition of 28.6 mm, 27.63 mm, and 29.33 mm for Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae, respectively compared to CS-ZnONPs. From the growth inhibition experiments with E. coli and Staphylococcus aureus, it was evident that GS-ZnONPs have exhibited higher growth inhibition as compared to CS-ZnONPs. The IC50 for CS-ZnONPs in MCF-7 cell line was found at 136.16 µg/mL and for GS-ZnONPs was found at 85.05 µg/mL. The proliferation of cancer cells were directly proportional to the concentration of NPs. As compared to CS-ZnONPs, GS-ZnONPs have exhibited higher cytotoxic effects on MCF-7 cell line.
Conclusion: It was concluded that GS-ZnONPs represented much enhanced anticancer and antibacterial activity compared to CS-ZnONPs.- انتشار مقاله: 31-06-1399
- نویسندگان: Karthigadevi Guruviah,Sathish Kumar Annamalai,Arulvel Ramaswamy,Chozhavendhan Sivasankaran,Subbaiya Ramasamy,Hamed Barabadi,Muthupandian Saravanan
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: silver nanoparticles,anticancer activity,nanotoxicity,Hepatic Cancer
- چکیده:
- چکیده انگلیسی: Nanoparticles are of highlighted interest in scientific research for a wide range of applications as they bridge the gap between atomic structures and bulk materials with unique physicochemical properties. This systematic review was aimed to study the current trends in biological mediated cancer research using biogenic silver nanoparticles (AgNPs) against hepatic cancer cell lines. For this purpose, the electronic databases including Cochrane Library, PubMed, Scopus, Science Direct, ProQuest, Embase, and Web of Science were searched. Forty-six studies passed the eligibility assessments and entered into the current study. All of the studies stated the size distribution of biosynthesized AgNPs below 100 nm with different shapes. Whereas, most studies stated spherical morphology for biogenic AgNPs. Most of the studies (91.30%) represented significant anticancer activity of biogenic AgNPs toward hepatic cancer cell lines. The molecular mechanisms also showed the induction of intracellular Reactive Oxygen Species (ROS) and apoptosis through the biogenic AgNPs-treated hepatic cancer cells. The AgNPs-mediated induction of intracellular ROS overgeneration and ATP synthesis interruption disturb the mitochondria respiratory chain function resulting in the induction of mitochondrial pathway apoptosis. Overall, this systematic review provided strong preliminary evidence representing the efficacy of biogenic AgNPs to combat hepatic cancer cells through in vitro models.
- انتشار مقاله: 25-05-1399
- نویسندگان: Hamed Barabadi,Hossein Vahidi,Masoumeh Rashedi,Mohammad Ali Mahjoub,Anima Nanda,Muthupandian Saravanan
- مشاهده