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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,Urinary dysfunction,Quality of life (QoL)
- چکیده:
- چکیده انگلیسی: Background: Carcinoma cervix is the second most common type of cancer in the world. With the increasing
proportion of women surviving carcinoma of the cervix, quality of life has been an important clinical issue. Since
there are very few studies from India, this study is to assess urinary dysfunction issues in patients of carcinoma cervix
treated with multimodality therapy using the LENT SOMA scores. Methods: The study was prospective and patients
treated between 1995 - 2007 on follow up were included in this study after ethical clearance. A total of 85 patients
were accrued comprising 6 stage IB, 6 stage II A, 25 stage II B, 2 stage IIIA, 45 stage III B and 1 stage IV A disease.
Sixty-six patients were treated with radiotherapy in which 46 patients received chemoradiotherapy and 19 had surgery
prior to post-operative radiotherapy. The mean age was 47.81 years with a range of 25-68 years. Completion of LENT
SOMA scale and Statistical analysis was done. Results: Mean score for BU (Bladder/Urethra) was highest (0.0758) in
fifth year of treatment whereas UK (Ureter/Kidney score was highest (0.0408) after 4 years. Bladder score was more in
60-69 years of age and in stage IIIB patients of cervical cancers. Bladder morbidity was more in patients who received
chemoradiotherapy and in patients who received radiotherapy with boost where Bladder and Urethra morbidity was more
in patients who were treated with Extended Field radiation. Conclusions: The LENT SOMA system was acceptable
and feasible to use and gave us an insight into the morbidity in our patients and to develop effective management plans
to reduce the post treatment symptoms and improve quality of life.- انتشار مقاله: 07-06-1397
- نویسندگان: Abhishek Shankar,Jaineet Patil,Niharika Sethi,Abhijit Chakraborty,Sachidanand Jee Bharti,Kavita Mandrelle,Anil Luther,Ruchir Bhandari,Goura Rath
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,incidence,Population based cancer registry,Annual percentage change
- چکیده:
- چکیده انگلیسی: Introduction: Lung cancer (LC) has been one of the most commonly diagnosed cancers worldwide, both in terms
of new cases and mortality. Exponential growth of economic and industrial activities in recent decades in the Delhi
urban area may have increased the incidence of LC. The primary objective of this study was to evaluate the time trend
according to gender. Method: LC incidence data over 25 years were obtained from the population based urban Delhi
cancer registry. Joinpoint regression analysis was applied for evaluating the time trend of age-standardized incidence
rates. The age-period-cohort (APC) model was employed using Poisson distribution with a log link function and the
intrinsic estimator method. Results: During the 25 years, 13,489 male and 3,259 female LC cases were registered,
accounting for 9.78% of male and 2.53% of female total cancer cases. Joinpoint regression analysis revealed that LC
incidence in males continued to increase during the entire period, a sharp acceleration being observed starting from
2009. In females the LC incidence rate remained a plateau during 1988-2002 and thereafter increased. The cumulative
risks for 1988-2012 were 1.79% and 0.45%. The full APC (IE) model showed best fit for an age-period-cohort effect
on LC incidence, with significant increase with age peaking at 70-74 years in males and 65-69 years in females. A
rising period effect was observed after adjusting for age and cohort effects in both genders and a declining cohort effect
was identified after controlling for age and period effects. Conclusion: The incidence of LC in urban Delhi showed
increasing trend from 1988-2012. Known factors such as environmental conservation, tobacco control, physical activity
awareness and medical security should be implemented more vigorously over the long term in our population.- انتشار مقاله: 05-10-1396
- نویسندگان: Rajeev Kumar Malhotra,Nalliah Manoharan,Omana Nair,Suryanarayana Deo,Goura Kishor Rath
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,treatment,Oral Mucositis
- چکیده:
- چکیده انگلیسی:
Oral Mucositis (OM) is among the most common and dreaded toxicities of cancer therapy. It occurs in almost all patients who receive radiation therapy in which areas of oral and oropharyngeal mucosa are included in the treatment field. With the advent of chemotherapy in 1940 and its extended clinical legacy, it is only within the past two decade or so that mucositis’ complex pathobiology has become fully appreciated. There are still many unanswered questions about the risk factors for developing OM, but historically, risk factors have been attributed to both therapy and patient m characteristics. One thing that has been consistent from the initial descriptions of its clinical manifestations has been the frustration on the part of clinicians and patients with the scarcity of therapeutic options to prevent or treat the condition, or effectively ameliorate the symptoms. Clinicians, researchers and those involved in oral and periodontal medicine should join hand in hand in persuit of understanding and developing treatment strategies for treatment of inflammatory conditions like OM in oncology. This will lead to development of effective treatments and reducing the burden of OM and other inflammatory conditions in oncology.- انتشار مقاله: 01-03-1396
- نویسندگان: Abhishek Shankar,Shubham Roy,Menal Bhandari,Goura Rath,Aalekhya Biswas,Ravi Kanodia,Narayan Adhikari,Rashika Sachan
- مشاهده