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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Pakistan,incidence,Registry,Karachi
- چکیده:
- چکیده انگلیسی: Objectives: To estimate the cancer incidence by age group and gender for the population of Karachi Division by analyzing the Karachi Cancer Registry data of 2017-19. Settings: The population of Karachi division is 16.1 million according to national census 2017. ‘Karachi Cancer Registry’ which is a part of ‘National Cancer Registry’ is collecting data from eight major hospitals in Karachi since 2017. For outcome measures, cancer counts and the age standardized incidence rates (ASIR) per 100,000 population were computed for age groups (0–14, 15–19 and ≥20 years), in both genders and all cancer site/type. Methods: The population denominators were based on the population of Karachi division estimated at 16.1 million in the population census, 2017. Counts and age-standardized incidence rates (ASIR) were calculated for each of the three age categories. Results: From Jan 2017 till Dec 2019 a total of 33,309 malignant cases were recorded in KCR database comprising 17,490 (52.5%) females and 15,819 (47.5%) males. ASIRs in age groups 0-14, 15-19 and ≥ 20 years, among female were 11.5, 2.4 and 223.6 and in males were 17.6, 3.2 and 216.7 respectively. The commonest diagnosis in children, adolescent and adults were (1) among females: children; bone (3.12), leukemia (2.09) brain/CNS (1.26); in adolescents: bone (0.78), brain/CNS (0.27), connective and soft tissue (0.11), in adults: breast cancer (76.07), oral cancer (16.68) and ovary (10.89) respectively, and (2) among males: children; bone (4.56), leukemia (2.79) and brain/CNS (1.88); in adolescent; bone (1.19), brain/CNS (0.31) and leukemia (0.21) and in adults: oral cancer (42.83), liver (16.10) and bone (13.37) respectively. Conclusion: Oral Cancer, a largely preventable cancer is the leading cancer in Karachi adult males while in female adults Breast Cancer is the leading cancer followed by Oral Cancer. In children and adolescents Bone, Leukemia and Brain/CNS malignancies are most common.
- انتشار مقاله: 24-03-1399
- نویسندگان: Shahid Pervez,Adnan A Jabbar,Ghulam Haider,Shamvil Ashraf,Muhammad Asif Qureshi,Fouzia Lateef,Imtiaz Bashir,Manzoor Zaidi,Mohammad Khurshid,Mohammad Saeed Quraishy,Tariq Siddiqi,Uzma Rizwan,Muhammad Arif Nadeem Saqib,Muhammad A Memon,Ejaz Alam,Huma Qureshi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,chemotherapy,head and neck cancer,induction chemotherapy,response rate
- چکیده:
- چکیده انگلیسی: Objective: To evaluate the response rate of Cisplatin plus Docetaxel in the treatment of locally advanced head and neck squamous cell carcinomas (HNSCC) at a tertiary care hospital in Karachi, Pakistan. Materials and Methods: It was a longitudinal study, conducted at the Department of Medical Oncology, Jinnah Postgraduate Medical Center, Karachi, Pakistan from December 2018 to June 2019. One hundred patients of age 14-66 years of age of either gender with histologically proven Squamous Cell Carcinoma of Head and Neck, Stage III and IV (locally advanced) with no distant metastases were included in the study. Patients who were declared unresectable by the otolaryngologist and those with delayed appointment for radiation were given 3 cycles of Induction Chemotherapy with Cisplatin and Docetaxel, both at a dose of 75mg/m2 3 weekly. After 3 cycles, CT scan was repeated to assess the clinical response. Those patients who had partial or complete response as per RECIST criteria were re-assessed by the otolaryngologist and were planned for surgery if disease became resectable while other patients were referred for Concurrent Chemo-Radiation Therapy (CCRT). SPSS version 23 was used to analyze data. Results: The partial response was achieved in majority of the patients after Induction Chemotherapy with Docetaxel and Cisplatin (62%) with a complete response in 12 %. However, 22% showed progression of the disease, and 4% showed stable disease. The most frequent side effects observed were diarrhea (62%) and neutropenia (57%). Conclusion: Induction chemotherapy with Cisplatin and Docetaxel is a promising regimen with good response and favorable toxicity profile and can be considered as a potentially effective outpatient regimen for locally advanced squamous cell carcinoma of head and neck.
- انتشار مقاله: 24-09-1398
- نویسندگان: Maryum Nouman,Ghulam Haider,Neelma Bukhari,Aveen Yousuf,Rabeea Nouman,Mehwish Roshan Shaikh,Shahid Hussain,Bhunisha Pavan,Raja Rahool,Paras Memon,Saima Zahoor,Khalil Mehar,Abdus Sami
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,quality,Pathology,Surgical,Reports
- چکیده:
- چکیده انگلیسی: Background: Surgical pathology reporting of breast cancer is needed for appropriate staging and treatment decisions.
We here checked the quality of surgical pathology reports of breast cancer from different laboratories of Karachi,
Pakistan. Methods: One hundred surgical pathology reports from ten different laboratories of Karachi were assessed
for documentation of elements against a checklist adopted from the CAP guideline over a period of six months from
January, 2017 to June, 2017 in the Oncology Department, Jinnah Postgraduate Medical Centre, Karachi. Results: Out
of 100 reports, clinical information was documented in 68%, type of procedure and lymph node sampling in 84%
and 34% respectively. Specimen laterality was mentioned in 90%, tumor site in 44%, tumor size in 92%, focality in
40%, histological type in 96%, grade in 87%, LCIS in 19%, DCIS in 83%, size of DCIS in 19%, architectural pattern
in 26% , nuclear grade in 17%, necrosis in 14%, excision margin status in 91%, invasive component in 83%, DCIS in
16%, lymph node status in 91% with positive nodes in 56%, size of macro met in 54%, extranodal involvement in 48%,
lymph vascular invasion in 86%, treatment effects in 31%, and pathology reporting with TNM in 57%. Conclusion:
This study shows that the quality of surgical pathology reports for breast cancer in Karachi is not satisfactory. Therefore,
there is great need to create awareness among histopathologists regarding the importance of accurate breast cancer
surgical pathology reporting and to introduce a standardized checklist according to international guidelines for better
treatment planning.- انتشار مقاله: 26-08-1396
- نویسندگان: Anita Vallacha,Ghulam Haider,Wiky Raja,Dinesh Kumar
- مشاهده