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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Food & Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Superoxide Dismutase,Malondialdehyde,Glutathione peroxidase,Non-Hodgkin lymphoma
- چکیده:
- چکیده انگلیسی: Imbalance in the production of oxidative molecules and antioxidant activity plays an important role in carcinogenesis. This study was performed to evaluate the serum level of malondialdehyde (MDA) as oxidative damage marker, superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) as an antioxidant defense system in non-Hodgkin's lymphoma (NHL). Twenty-five NHL patients and twenty-five healthy individuals were included in the study. The data showed that lower activity of enzymatic antioxidants (GPx, SOD) and higher MDA levels in NHL patients than in the control group. The results suggest that increased serum MDA and decreased SOD and GPx activity may be due to oxidative stress, which may play an important role in NHL formation. the role of oxidative stress in the pathogenesis of the NHL has not been extensively studied. Therefore, the present study aimed to measure the level of MDA as well as GPx and SOD activity in blood tissue collected from NHL patients compared with the control group.
- انتشار مقاله: 03-11-1398
- نویسندگان: Hosnie Hoseini,Parichehreh Yaghmaei,Gholamreza Bahari,Saeed Aminzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Food & Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Superoxide Dismutase,Malondialdehyde,Glutathione peroxidase,Non-Hodgkin lymphoma
- چکیده:
- چکیده انگلیسی: Imbalance in the production of oxidative molecules and antioxidant activity plays an important role in carcinogenesis. This study was performed to evaluate the serum level of malondialdehyde (MDA) as oxidative damage marker, superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) as an antioxidant defense system in non-Hodgkin's lymphoma (NHL). Twenty-five NHL patients and twenty-five healthy individuals were included in the study. The data showed that lower activity of enzymatic antioxidants (GPx, SOD) and higher MDA levels in NHL patients than in the control group. The results suggest that increased serum MDA and decreased SOD and GPx activity may be due to oxidative stress, which may play an important role in NHL formation. the role of oxidative stress in the pathogenesis of the NHL has not been extensively studied. Therefore, the present study aimed to measure the level of MDA as well as GPx and SOD activity in blood tissue collected from NHL patients compared with the control group.
- انتشار مقاله: 03-11-1398
- نویسندگان: Hosnie Hoseini,Parichehreh Yaghmaei,Gholamreza Bahari,Saeed Aminzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: long non-coding RNA,Polymorphism,Acute Lymphoblastic Leukemia,lnc-LAMC2-1:1,CASC8
- چکیده:
- چکیده انگلیسی:
Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are involved in a wide variety of biological processes. There are limited data regarding the impact of lnc-LAMC2-1:1 rs2147578 as well as CASC8 rs10505477 T>C polymorphisms on cancer development. Here we examined for the first time whether rs2147578 and rs10505477 polymorphisms are associated with childhood acute lymphoblastic leukemia (ALL) in a total of 110 cases and 120 healthy controls. Genotyping was achieved by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The rs2147578 variant increased the risk of ALL in codominant (OR=4.33, 95%CI=2.00-9.37, p<0.0001, CG vs CC, and OR=5.81, 95%CI=2.30-14.69, p=0.0002, GG vs CC), dominant (OR=4.63, 95%CI=2.18-9.86, p<0.0001, CG+GG vs CC), overdominant (OR=1.74, 95%CI=1.02-2.97, p=0.0444, CG vs CC+GG) and allele (OR=1.91, 95%CI=1.32-2.77, p=0.0008, G vs C) inheritance models tested. No significant association was found between the CASC8 rs10505477 T>C variant and risk of childhood ALL. In conclusion, the present study revealed that the lnc-LAMC2-1:1 rs2147578 polymorphism may be a risk factor for developing childhood ALL. Further studies with larger sample sizes with different ethnicities are now required to confirm our findings.- انتشار مقاله: 17-07-1395
- نویسندگان: Mohammad Hashemi,Gholamreza Bahari,Majid Naderi,Simin Sadeghi-Bojd,Mohsen Taheri
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Apoptosis,PD-L1,Polymorphism,PD-1
- چکیده:
- چکیده انگلیسی: Introduction: Programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2) play a critical role as a regulator of immune-system cells, including T cell, natural killer T (NKT), monocytes, dendritic cells (DC), and B cells. Objective: This study aimed to find a possible association between PD-1 (rs11568821, rs2227981, rs2227982), and PD-L1 (rs4143815, rs2890658) variants and Breast Cancer (BC) risk in a sample of southeast Iranian women. Method: The case-control study consisted of 520 individuals, including 260 histologically confirmed BC patients and 260 non-cancer age-matching healthy women as the control group. The Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) methods were used for genotyping of PD-1 (rs11568821, rs2227981, rs2227982), and PD-L1 (rs4143815, rs2890658) polymorphisms. Results and Conclusion: Our findings indicated that the PD-L1 rs4143815 (G/C) variant meaningfully reduced the risk of BC. However, the PD-L1 rs2890658 variant increased the BC risk in the AC genotype as well as the A allele. Furthermore, we could not find a meaningful association between PD-1 rs11568821, PD-1 rs2227981, PD-1 rs2227982, and BC. Our team examined the possible association between variants and clinicopathological characteristics, including age, size of tumour, lymph node, histology, grade of tumour, estrogen and progesterone receptors status as well as human growth factor receptor 2 (HER2). Our findings demonstrated that PD-L1 rs4143815, PD-L1 rs2890658, PD-1 rs2227982 had a significant association with age. Additionally, we found a significant relation between PD-1 rs2227982 variant and tumour size. Statistical analyzes of PD-1 rs2227981 and PD-1 rs11568821 variants showed a meaningful relation between tumour grade and tumour stage (p=0.006), respectively.
- انتشار مقاله: 12-04-1399
- نویسندگان: Shima Karami,Hedieh Sattarifard,Mohammad Kiumarsi,Sahel Sarabandi,Mohsen Taheri,Mohammad Hashemi,Gholamreza Bahari,Saeid Ghavami
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,genetic polymorphisms,Smad7,MIR-375
- چکیده:
- چکیده انگلیسی: Background: Today, the role of microRNAs in the pathogenesis of breast cancer has been established. Genetic mutations play a significant role in determining the risk factors of cancer. The polymorphism of these two genes can alter their expression. This study has been performed to investigate the relationship between polymorphisms of rs6715345 of miR-375 gene and rs4939827 of the SMAD7 gene and development of breast cancer in a population in southeastern Iran. Methods: This case-control study was performed on the blood sample of 205 patients with breast cancer and 200 healthy individuals for investigating the rs34917480 and rs4939827 polymorphisms using the PCR-RFLP method. The data were analyzed by t-test, χ2, and logistic regression. The SPSS v18.0 used for data analysis. Results: The findings of this study indicated that the risk of developing breast cancer does not have a significant relationship with rs6715345 polymorphism of miR-375 gene (p<0.1). However, the rs4939827 polymorphism of the SMAD7 gene was significantly linked to the risk of developing breast cancer in the southeastern population in Iran (p>0.01). Conclusion: The results suggest that the rs4939827 polymorphism of the SMAD7 gene can lead to an increased risk of incidence of breast cancer in the southeastern population in Iran.
- انتشار مقاله: 21-04-1399
- نویسندگان: Seyed-Mehdi Hashemi,Mohammad Hashemi,Gholamreza Bahari,Afsaneh Khaledi,Hoseinali Danesh,Abolghasem Allahyari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Telomere Length,TERT genetic polymorphisms, Childhood acute lymphoblastic leukemia
- چکیده:
- چکیده انگلیسی: Background: Telomeres are involved in chromosomal stability, cellular immortality and tumorigenesis. Human
telomerase reverse transcriptase (TERT) is essential for the maintenance of telomere DNA length. Recently, a variable
tandem-repeats polymorphism, MNS16A, located in the downstream region of the TERT gene, was reported to have
an effect on TERT expression and telomerase activity. Previous studies have linked both relative telomere length
(RTL) and TERT variants with cancer. Therefore, we evaluated associations between RTL, TERT gene polymorphisms
(hTERT, rs2735940 C/T and MNS16A Ins/Del) and risk of childhood acute lymphoblastic leukemia (ALL) in an Iranian
population. Methods: RTL was determined by a multiplex quantitative PCR-based method, and variants of the hTERT,
rs2735940 C/T and MNS16A Ins/Del, were genotyped by amplification refractory mutation system PCR (ARMS-PCR),
and PCR, respectively. Results: Our results indicated that RTL was shorter in ALL patients (1.53±0.12) compared to
the control group (2.04±0.19) (P=0.029). However, no associations between hTERT gene variants or haplotypes and
the risk of childhood ALL were observed (P>0.05). Also hTERT polymorphisms were not associated with RTL or
patient clinicopathological characteristics, including age (P=0.304), sex (P=0.061) organomegally (P=0.212) CSF
involvement (P=0.966) or response to treatment (P=0.58). Conclusions: We found that telomere attrition may be
related to the pathogenesis of childhood ALL, irrespective to TERT variants.- انتشار مقاله: 04-05-1396
- نویسندگان: Ebrahim Eskandari,Mohammad Hashemi,Majid Naderi,Gholamreza Bahari,Vahid Safdari,Mohsen Taheri
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Polymorphism,EGLN2,deletion
- چکیده:
- چکیده انگلیسی: It has been shown that a 4-bp insertion/deletion (ins/del) polymorphism of EGLN2 influences the risk of several
cancers. However, to date, no study has inspected the impact of the 4-bp ins/del polymorphism on breast cancer (BC)
risk. A case-control study, including 134 breast cancer patients and 154 healthy women, was here conducted to examine
the possible association between EGLN2 4-bp ins/del polymorphism and BC risk in a southeast Iranian population.
A mismatched polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was designed for
genotyping of the variant. Our findings did not support any association between the 4-bp ins/del polymorphism and
the risk of BC in the codominant, dominant, recessive and allele inheritance models tested. When links between
the EGLN2 4-bp ins/del polymorphism and clinicopathological characteristics of the patients were evaluate the variant
was only associated with HER2 status. More studies with larger sample sizes and diverse ethnicities are warranted to
verify our finding.- انتشار مقاله: 20-03-1396
- نویسندگان: Mohammad Hashemi,Hiva Danesh,Fatemeh Bizhani,Hedieh Sattarifard,Seyed Mehdi Hashemi,Gholamreza Bahari
- مشاهده