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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: carcinogenesis,cancer biomarkers,Molecular biology
- چکیده:
- چکیده انگلیسی: Background: Protocadherins (PCDHs) have been reported as tumor suppressor genes, implying that these genes may be involved in tumor suppression in a variety of cancers. However, a thorough understanding of the functions and mechanisms of PCDHs remains limited. Our aim was to investigate the methylation profile of PCDHs in human malignant neoplasms. Methods: This systematic review has been recorded in PROSPERO (#42019117844) and conducted according to PRISMA’s checklist; search was conducted in LILACS, PubMed, Science Direct, Scopus, and Web of Science databases, manually, with search queries and without date or language restrictions. Results: We found 91 articles, of which 26 were used for this meta-analysis and categorized according to the origin of the neoplasia. In total, 3,377 cases were compiled, with PCDH10, PCDH17, and PCDH8 being the most studied; males were 2.22 times more affected than females. Studies have shown significant heterogeneity (p <0.001), with the odds ratio varying between cases and controls [2.20 (95% CI = 1.11– 4.35) to 209.05 (95% CI = 12.64– 2,457.18)], and the value of association between methylation and cancers studied was 26.08 (95% CI = 15.42–44.13). Conclusion: In this systematic review, we have demonstrated using meta-analysis that PCDHs could emerge as potential tumor suppressor genes and that a significant increase in methylation may be useful for early detection of different cancers. This work may help in the identification of new prognostic biomarkers in malignant neoplasms.
- انتشار مقاله: 15-05-1399
- نویسندگان: Thaís Torres Barros Dutra,Thâmara Manoela Marinho Bezerra,Ealber Carvalho Macêdo Luna,Francisco Samuel Rodrigues Carvalho,Filipe Nobre Chaves,Paulo Goberlânio De Barros Silva,Fábio Wildson Gurgel Costa,Karuza Maria Alves Pereira
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: immunohistochemistry,oral squamous cell carcinoma,oral epithelial dysplasia,GLUT proteins
- چکیده:
- چکیده انگلیسی: Objectives: To evaluate immunohistochemically the expression of GLUT-3 and GLUT-4 in oral epithelial dysplasia
(OED) and the oral squamous cell carcinoma (OSCC) and assess possible involvement in the malignant transformation of
oral lesions. Methods: Tissue samples of 15 cases of OSCC and 15 of OED were subjected to immunohistochemistry
with anti-GLUT-3 and anti-GLUT-4 antibodies. Five fields of each case were analyzed, to provide percentages of
positive cells at 400X magnification. Result: GLUT-3 and GLUT-4 were positive in 100% of the analyzed samples,
the percentage immunolabeling for GLUT-3 ranging from 19% to 73% in the OED group and 10% to 89% in the OSCC
group. Positive immunolabeling for GLUT-4 ranged from 15.2% to 79.9% in the OSCC group and 27.1% to 92.6% in
the OED group. Statistical analysis with the Mann-Whitney test revealed that there was a higher expression of GLUT-4 in
the OED group than in the OSCC group (p=0.04) without any significant difference in the GLUT-3 expression (p=0.852).
Conclusion: GLUT-4 expression may indicate some role in oncogenic mechanisms which can determine a malignant
phenotype. Thus, it is suggested that further studies on the role of GLUT-3 in oral carcinogenesis be conducted.- انتشار مقاله: 04-04-1396
- نویسندگان: Sthefane Gomes Feitosa,Khalil Fernandes Viana,Ealber Carvalho Macedo Luna,Fábio Wildson Gurgel Costa,Roberta Barroso Cavalcante,Filipe Nobre Chaves,Hellíada Vasconcelos Chaves,Karuza Maria Alves Pereira
- مشاهده