در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Gene expression,Nanog,SOX2,Oct4
- چکیده:
- چکیده انگلیسی: Objective: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral neoplasms. Finding molecular
markers for predicting prognosis is a high priority. The core transcription factors, OCT4, SOX2, and NANOG that
regulate embryonic stem cell pluripotency have been implicated in progression of various malignancies. The predictive
value of these markers and their role in the development of OSCC is still controversial. In this study, we therefore
evaluated their expression in OSCCs and adjacent non-tumor tissue. Methods: A total of 60 frozen tumor and adjacent
non-tumor tissue samples from 30 patients with OSCC were examined using quantitative reverse transcription polymerase
chain reaction (qRT-PCR). Clinical and pathological data of patients including tumor stage, lymph node metastasis
and tumor grade were also recorded. Results: Expression of SOX2 was significantly higher in adjacent non-tumor as
compared to tumor tissue (P=0.04). No statistically significant differences were found for expression of OCT4 (P=0.50)
and NANOG (P=0.68). Also, there was no significant association between expression of OCT4, SOX2, and NANOG
and clinical or pathological data (P>0.05), although slightly higher values were noted in patients without lymph node
metastasis. Conclusion: Based on the present data, decreased expression of SOX2 is correlated with carcinogenesis
in the oral cavity and development of OSCC.- انتشار مقاله: 06-10-1396
- نویسندگان: Fereshteh Baghai Naini,Pouyan Aminishakib,Alireza Abdollahi,Mahshid Hodjat,Hadiseh Mohammadpour,Neda Kardouni Khoozestani
- مشاهده