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- جایگاه : پژوهشی
- مجله: Women’s Health Bulletin
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Women,Diet,Communicable Disease
- چکیده:
- چکیده انگلیسی: Context: Diet is an important component of life and plays a key role in the prevention or development of non-communicable diseases. The aim of this systematic review was to determine different dietary patterns and their association with non-communicable diseases in Iranian women. Evidence Acquisition: Sources of Information: an electronic literature search was conducted on websites such as Pubmed, Science direct, Google scholar, Sid, and Iranmedex to identify original human studies, published in English and Persian up to August 2013 that included keywords or phrases relevant to the aim of this study. Results: Studies were classified into eight groups according to their objectives and outcomes, including the relationship between dietary patterns and aspects such as bone mineral density, metabolic syndrome, obesity, cardiovascular disease, cancer, markers of inflammation, hypertension, coagulation abnormalities, life style and factor analysis. Compared to healthy dietary patterns, the western and Iranian patterns were positively associated with conditions related to non-communicable diseases. The dietary approach to stop hypertension (DASH) is rich in fruits, vegetables, whole grains, low-fat dairy products, and is low in saturated fat, total fat, cholesterol, refined grains, and sweets. This diet is associated with greater high-density lipoprotein (HDL) cholesterol and lower body weight, waist circumference, fasting blood glucose, low-density lipoprotein (LDL) cholesterol and systolic and diastolic blood pressures. Conclusions: Adherence to a healthy dietary pattern is expected to secure a protective effect against non-communicable disease.
- انتشار مقاله: 11-10-1348
- نویسندگان: Parvin Mirmiran,Arefeh Fallah Ghohroudy,Somayeh Hosseinpour Niazi,Batol Ahmadi,Fatemeh Nayeri,Fereidoun Azizi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iranian population,RET proto-oncogene,medullary thyroid cancer,Exon 10,Germline mutation
- چکیده:
- چکیده انگلیسی: Background & Aims: Thyroid cancer is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) is an aggressive malignant tumor arising from parafollicular cells of the thyroid. MTC occurs in hereditary (25%, hMTC) or sporadic (75%, sMTC) forms. The hMTC form has an autosomal dominant inheritance. RET proto-oncogene mutations, especially the 10, 11, and 16 exones, are associated with MTC. The aim of this study was to determine the type and frequency of RET proto-oncogene exon 10 in patients with MTC. Methods: The study participants included 347 individuals, including 207 patients and 140 of their first degree relatives. Genomic DNA was extracted from peripheral leukocytes using salting out/Proteinase K method. All individuals were tested for RET mutations in exon 10 using polymerase chain reaction (PCR)- DNA sequencing method. Results: A total of 14 germline missense RET mutations were identified in cysteine codons 611, 618, and 620 in 11 patients(10 mutation in males, 4 in females), and 3 of their first-degree relatives (frequency: 3.6%) which were as follows: four C611Y (three FMTC, one relative), one C618R (FMTC), one C618S (sMTC), one C620G (sMTC), four C620R (one FMTC, three sMTC), and three C620F (one FMTC, two relatives). The most predominant mutations in exon 10 in our FMTC and sMTC patients were C611Y and C620R, respectively. We did not find any mutations in cysteine codon 609. Conclusion: In the present study, 6 different types of missense mutations were identified in exon 10 of RET in the nonsyndromic form of MTC. Based on the results of this study, mutation detection using DNA sequencing in exons 10, 11, and 16 of RET in patients with MTC and their relatives is recommended.
- انتشار مقاله: 24-04-1395
- نویسندگان: Marjan Zarif-Yeganeh,Sara Sheikholeslami,Golnoush Dehbashi-Behbahani,Samaneh Farashi,Laleh Hoghooghi-Rad,Fereidoun Azizi,Mehdi Hedayati
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Insulin resistance,hypertension,Metabolic Syndrome,Dyslipidemia,Abdominal obesity,unhealthy snacks
- چکیده:
- چکیده انگلیسی: Background & Aims: Unhealthy snacks contain high amounts of calories, simple sugars, fat, cholesterol, salt, additives, and conservatives. Increased consumption of these unhealthy snacks is one of the underlying factors for the prevalence of overweight, obesity, and metabolic disorders. In this study, we investigated the effects of unhealthy snacks on diet and the risk of metabolic syndrome after 3-years of follow-up in Tehranian adults. Methods: This longitudinal study was conducted within the framework of the Tehran Lipid and Glucose Study, between 2006-2008 and 2009-2011, on men and women in Tehran, Iran. Dietary intakes of participants were measured using a validated semi-quantitative food frequency questionnaire at baseline. Biochemical and anthropometric measurements were assessed at baseline and 3 years later. Multiple logistic regression models with adjustment for confounding factors were used to estimate the occurrence of metabolic syndrome (MetS) in each quartile of unhealthy snacks. Results: The mean age of participants was 37.8 ± 12.3 years, and the mean of body mass index was 26.0 ± 4.5 kg/m2 . Moreover, 39% of the participants were male. Daily energy intake, dietary energy density, and total fat and sodium intake were higher in the fourth quartile of unhealthy snacks consumption. There was a significant decreasing trend in dietary intake of carbohydrate, calcium, zinc, selenium, and fiber parallel to increase in consumption of energy-dense snacks. Participants who were in the highest quartile of energy intake from unhealthy snacks consumed less whole grains, vegetables, and dairy products. After adjustment for potential confounders, the risk of metabolic syndrome had a significant positive association with salty snacks consumption, and a non-significant positive association with consumption of candies, chocolate, and soft drinks. Conclusion:Increased daily energy intake from unhealthy snacks could be a risk factor for the occurrence of metabolic syndrome.
- انتشار مقاله: 25-04-1395
- نویسندگان: Zahra Bahadoran,Parvin Mirmiran,Sahar Mirzaee,Hossein Delshad,Fereidoun Azizi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Thyroid,iodine,Goiter,iodized salt
- چکیده:
- چکیده انگلیسی: Background: The iodine deficiency elimination program that began two decades ago resulted in Iran becoming an iodine deficiency disorders free country in the Middle East region. The present study was performed to evaluate the adequacy of iodine supplementation after 17 years of universal salt iodization in Fars province. Methods: In a cross-sectional study, 1200 schoolchildren (480 girls and 720 boys) aged 8 to10 years, were randomly selected from Fars province and evaluated in 2007. Goiter prevalence, urinary iodine excretion, and iodine content of household salts were measured and the data were compared with those obtained in 1996 and 2001. Results: Total prevalence of goiter was 1.3% (CI: 0.53-2.47) and no grade 2 goiter was found. One-tenth of the children enrolled for goiter assessment, were randomly selected for urinary iodine measurement. The median urinary iodine in these 120 schoolchildren was 159.4 µg/L (85.6-252.3), with 14.8% having urinary iodine excretion less than 50 µg/L. 98% of households were using purified iodized salt. 70% of households had appropriate salt storage and none of the household salts contained less than 15 µg iodide. Conclusion: Goiter prevalence has significantly decreased in the Fars province, 17 years after universal salt iodization. The median urinary iodine of schoolchildren was adequate as that reported in 1996 and 2001, indicating a well established sustainable iodine deficiency elimination program in the province
- انتشار مقاله: 11-12-1393
- نویسندگان: Atieh Amouzegar,Hossein Delshad,Mehran Mehraein,Ladan Mehran,Maryam Safarkhani,Fereidoun Azizi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Stroke,Survival analysis,Coronary Heart Disease,Cholesterol HDL,Cholesterol LDL
- چکیده:
- چکیده انگلیسی: Objective(s): It has been proposed that lipid markers may predict cardiovascular events; however, their effect may vary depending on the type of cardiovascular disease. The purpose of this study was to investigate the effects of lipid markers on death from coronary heart disease (CHD) and stroke in competing risks setting.
Materials and Methods: Participants included 2502 women and 2020 men, age 40 years or older from Tehran Lipid and Glucose Study. The association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) with hazard and cumulative incidence of CHD and stroke was investigated using cause-specific hazard and sub-distribution hazard models. Statistical analyses were performed using “risk regression” and “cmprsk” package in R 3.3.2.
Results: One standard deviation (SD) increase in TC and LDL-C increased the hazard of CHD death by 1.42 (CI=1.07,1.89) and 1.41 (CI=1.04,1.93), respectively. 1-SD increase in TG increased the cumulative incidence of CHD death increased by 1.94 (CI=1.02,3.75) in women. Other risk factors were not associated with the hazard and cumulative incidence of CHD in women, men and the total sample. In addition, none of lipids had a significant effect on the hazard and cumulative incidence of stroke in men, women and the total sample.
Conclusion: The associations of lipid components on CHD death were modified by gender. TC, LDL-C and TG were independent predictors of CHD mortality in women. Furthermore, death due to stroke changes the association of lipid markers with CHD mortality.- انتشار مقاله: 20-09-1397
- نویسندگان: Bagher Pahlavanzade,Farid Zayeri,Taban Baghfalaki,Omid Mozafari,Davood Khalili,Fereidoun Azizi,Alireza Abadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Stroke,Survival analysis,Coronary Heart Disease,Cholesterol HDL,Cholesterol LDL
- چکیده:
- چکیده انگلیسی: Objective(s): It has been proposed that lipid markers may predict cardiovascular events; however, their effect may vary depending on the type of cardiovascular disease. The purpose of this study was to investigate the effects of lipid markers on death from coronary heart disease (CHD) and stroke in competing risks setting.
Materials and Methods: Participants included 2502 women and 2020 men, age 40 years or older from Tehran Lipid and Glucose Study. The association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) with hazard and cumulative incidence of CHD and stroke was investigated using cause-specific hazard and sub-distribution hazard models. Statistical analyses were performed using “risk regression” and “cmprsk” package in R 3.3.2.
Results: One standard deviation (SD) increase in TC and LDL-C increased the hazard of CHD death by 1.42 (CI=1.07,1.89) and 1.41 (CI=1.04,1.93), respectively. 1-SD increase in TG increased the cumulative incidence of CHD death increased by 1.94 (CI=1.02,3.75) in women. Other risk factors were not associated with the hazard and cumulative incidence of CHD in women, men and the total sample. In addition, none of lipids had a significant effect on the hazard and cumulative incidence of stroke in men, women and the total sample.
Conclusion: The associations of lipid components on CHD death were modified by gender. TC, LDL-C and TG were independent predictors of CHD mortality in women. Furthermore, death due to stroke changes the association of lipid markers with CHD mortality.- انتشار مقاله: 20-09-1397
- نویسندگان: Bagher Pahlavanzade,Farid Zayeri,Taban Baghfalaki,Omid Mozafari,Davood Khalili,Fereidoun Azizi,Alireza Abadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Metabolic Syndrome,Interaction,CETP polymorphism,Dietary fats,Dietary macronutrients
- چکیده:
- چکیده انگلیسی: Objective(s): There are controversial results regarding the effect of the interaction of CETP polymorphisms with dietary fats on the lipid profiles. The aim of this study was to examine the effect of CETP polymorphisms (rs5882 and rs3764261) and macronutrient intakes interaction in relation to metabolic syndrome (MetS) or its components.
Materials and Methods: In this nested case-control study, subjects were selected from among participants of the Tehran Lipid and Glucose Study. Cases (n=441) were individually matched with two controls (844 non-MetS subjects). DNA samples were genotyped with HumanOmniExpress-24-v1-0 bead chips, including 649,932 SNP loci.
Results: The mean ages at baseline were 38.1±10 and 37.0±10 years in women and 36.2±11 and 36.3±11 years in men, respectively in cases and controls. We did not find significant gene-diet interactions between rs5882 and dietary macronutrient intakes in relation to MetS risk. The risk of low HDL-C was lower in the first quartile of MUFA and total fat intake in G allele carriers, compared to AA genotype group. The risk of high BP appeared to increase significantly in higher quartiles of trans-fatty acid intakes (>1.81% of total energy intake) in G allele carriers compared with the AA genotype group. No significant interactions were found between rs3764261 and macronutrient intakes in association with MetS or its components.
Conclusion: Our findings demonstrate that dietary fats modify the association of rs5882 and risk of low HDL-C and high blood pressure.- انتشار مقاله: 17-07-1396
- نویسندگان: Zohre Esfandiar,Firoozeh Hosseini-Esfahani,Maryam Daneshpour,Hamid Zand,Parvin Mirmiran,Fereidoun Azizi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Obesity,IL-6,Inflammatory Markers,Hcy,Hs-CRP,TLGS
- چکیده:
- چکیده انگلیسی: Objective(s):Obesity considered being a low-grade inflammatory disease. The objective of this study was to examine the association between inflammatory markers (IM) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and homocystein (Hcy) and obesity[F1] -related factors (e.g. BMI, waist, hip) in adult participants of Tehran lipid and glucose study (TLGS).
Materials and Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years, were randomly recruited from participants of TLGS population[F2] . The serum levels of hs-CRP, IL-6, Hcy were determined using the enzyme linked immunosorbent assay (ELISA) method[F3] . Variables were compared by sample t-test. Bivariate linear correlation was estimated using Pearson’s correlation coefficient. Linear regression analysis was applied to investigate the association between IMs and anthropometric and biochemical variables.
Results: The mean age of participants was 46.1±16.1 years. abdominal obesity was present in 199(56.5%) individuals. levels of hs-CRP and IL-6 increased in the abdominally obese group (1507±3.3 vs. 577.8±4.3 ng/ml P<0.001) (3.6±3.3 vs. 1.9±3.8 pg/ml P< 0.001), and in the same group, the best predictors for hs-CRP, IL-6 and Hcy were waist (WC), waist to height ratio (WHtR) and wrist respectively; hip and WHtR were the best predictors for Hcy and hs-CRP in the normal group. A linear augmentation in hs-CRP and IL-6 levels was observed in association with obesity categorizes.
Conclusion: This study provides evidence that abdominally obese individuals had higher levels of IMs. Wrist, waist and WHtR were the best predictors for Hcy, hs-CRP and IL-6 respectively in this group.
- انتشار مقاله: 05-06-1393
- نویسندگان: Bita Faam,Maryam Zarkesh,Maryam Sadat Daneshpour,Fereidoun Azizi,Mehdi Hedayati
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Anaplastic thyroid carcinoma,CD133 antigen,Phosphoinositide-3-kinase,Sodium-iodide symporter
- چکیده:
- چکیده انگلیسی:
Background: Thyroidectomy, radioactive iodine therapy, chemotherapy, or their combination are treatments of choice for thyroid cancers. However, cancer stem cells (CSCs) may become resistant to therapy, and mutations in somatic genes affect radioiodine uptake. This study determined the effect of a phosphoinositide-3-kinase (PI3K) inhibitor on anaplastic thyroid CSCs. Materials and Methods: The magnetic-activated cell sorting assay was used for segregating CD133-positive CSCs from three anaplastic thyroid carcinoma (ATC) cell lines (C643, SW1736, and 8305C). After confirming the cells’ purity by flow cytometry, they were treated with 5, 10, 20, or 25 μM LY294002, a PI3K inhibitor, and then evaluated at 24 and 48 h. The sodium-iodide symporter (NIS) mRNA level was determined using the quantitative real-time polymerase chain reaction. NIS protein expression was evaluated using western blotting. Results: The PI3K inhibitor, at different concentrations and times, increased the NIS mRNA level (1.30-6.17-fold, P < 0.0001). If the NIS mRNA level in LY294002-treated CD133-positive CSCs was increased more than 2-fold, the NIS protein content was detectable. Conclusions: CD133-positive CSCs isolated from ATC cell lines expressed NIS mRNA and protein after PI3K inhibition. Our findings suggest that molecularly targeted CSC therapy may improve the treatment efficacy of aggressive cancers like ATC.- انتشار مقاله: 27-03-1396
- نویسندگان: Farzaneh Bozorg-Ghalati,Mehdi Hedayati,Mehdi Dianatpour,Fereidoun Azizi,Nariman Mosaffa,Davood Mehrabani
- مشاهده