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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Middle East Journal of Cancer
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: There has been a rapid increase in cancer among Sudanese citizens from 1999 until this year. At least 80% of all patients who undergo chemotherapy will develop anemia as a complication. This inpatient analytical comparative study aims to examine the possible association between hemotoxicity and various chemotherapy regimens in Sudanese children diagnosed with retinoblastoma. Methods: This study enrolled 30 patients diagnosed with childhood retinoblastoma who were admitted from June 2006 to September 2008 to the Radiation and Isotope Center Khartoum. We collected 90 blood samples to examine for a possible association between anemia and the chemotherapeutic regimen. All patients (n=30) were included in each arm of the chemotherapy regimen.Results: Prior to the onset of chemotherapy, 50% of patients had normal hemoglobin levels, 43.3% had mild anemia, and 6.7% had moderate anemia. Post-cycle I treatment, there were only 6.7% who had normal hemoglobin levels. Mild anemia was observed in 60%, followed by 30% for moderate anemia and 3.3% of patients had severe anemia. Post-cycle II there were no patients with normal hemoglobin levels, however 26.7% had mild anemia and the majority of patients (approximately 73.3%) had moderate anemia.Conclusion:A correlation existed between hemoglobin values after completion of therapy to the overall treatment. We observed a decline of 1 to 2 g/dl in hemoglobin levels.
- انتشار مقاله: 06-07-1392
- نویسندگان: Fathelrahman Mahdi Hassan,Fathelrahman Mahdi Hassan,Fathelrahman Mahdi Hassan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: CML,Polymorphism,OGG1 rs1052133,Sudanese
- چکیده:
- چکیده انگلیسی: Background: In some cancer cells, the OGG1 gene is somatically mutated and highly populated. This study was
conducted to examine whether OGG1 rs1052133 polymorphism is associated with the genetic background of chronic
myelogenous leukaemia (CML) in Sudan. Methods: A total of 332 CML patients and 70 healthy controls were included
in this study. Overall, the genotypes (P=0.0000) and allele (C vs. G, P=0.0007) differed considerably in the frequencies
of OGG1 rs1052133 polymorphism between CML patients and controls. Our study is the first to evaluate the association
of polymorphism with CML risk with OGG1 rs1052133. Results: A statistically significant association was observed
between the genotype distribution of OGG1 rs1052133 polymorphism and CML (P=0.0000) patients. A similar result
was also observed in the allele distribution (C vs. G, P=0.0007) compared with healthy controls when compared
OGG1 rs1052133 genotypes with CML stages. Results: Genotype and allele frequencies of OGG1 rs1052133 among
CML patients. A statistically significant association was observed between the genotype distribution of the OGG1
rs1052133 polymorphism and CML patients (P=0.0000). A similar result was also observed in the allele distribution
(C vs. G, P=0.0007) compared with healthy controls with stages of CML in OGG1 rs1052133 genotypes. Conclusion:
The results suggest that single nucleotide polymorphism in the gene involved in the restoration of DNA base excision
(OGG1 rs1052133) can play a key role in the risk of appearance of CML. To clarify the role of OGG1 in the genetic
basis of CML, further case control with larger sample sizes and fine-mapping is required.- انتشار مقاله: 09-08-1397
- نویسندگان: Fathelrahman M Hassan,Fathelrahman M Hassan,Fathelrahman M Hassan,Fathelrahman M Hassan
- مشاهده