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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Research Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Salvia officinalis,Antibacterial activity,silver nanoparticles,Cytotoxicity,Antileishmanial effects
- چکیده:
- چکیده انگلیسی: Objective: This study aimed to investigate the cytotoxicity, antileishmanial and antibacterial potential of silver nanoparticles (AgNPs) synthesized by (Salvia officinalis L. (Sage)) extract.
Methods: The green synthesized nanoparticles were analyzed by using UV–vis spectroscopy, FTIR, and FESEM techniques. Cytotoxicity antileishmanial assay was evaluated by MTT.
Results: The UV–vis spectroscopy study at the band of 430 nm confirmed the formation of nanoparticles. FT-IR confirmed the presence of the ingredients in salvia leaf extract which is responsible for capping and reduction of the silver nanoparticles. FESEM report showed that the AgNPs synthesized were in the size range 30–70 nm. The AgNPs exhibited good cytotoxic activity against Hek-293, the breast cancer cell line (MCF 7) and a human glioblastoma cell line (A 172) with an IC50 value of 240, 50.40 and 58.60 µg/mL, respectively. The present study confirmed good antileishmanial activity against the promastigote and amastigote stages of Leishmania major in a dose-dependent manner. IC50 values of AgNPs were 62.91 and 73.89 μg/mL using promastigote and amastigotes assay respectively. AgNPs showed potent antibacterial activity against three bacteria species S. aureus, B. subtilis, and MRSA (Methicillin-resistant Staphylococcus aureus) at high concentrations. According to disk diffusion results, AgNPs at concentration 1000 µg/mL showed a significant inhibitory zone against S. aureus and B. subtilis. The AgNPs at a concentration higher than 750 µg/mL showed the valuable inhibitory zone against MRSA.
Conclusion: this study confirmed good cytotoxicity, and antileishmanial activity in the nanoparticles synthesized using S. officinal extract, so it can be further investigated for biomedical applications.- انتشار مقاله: 27-05-1399
- نویسندگان: Fatemeh Sharifi,Fariba Sharififar,Sara Soltanian,Mohsen Doostmohammadi,Neda Mohamadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Optimization in Industrial Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: optimization,Genetic Algorithm,Neural network,Solution space,Control variable
- چکیده:
- چکیده انگلیسی: Injection molding is one of the most important and common plastic formation methods. Combination of modeling tools and optimization algorithms can be used in order to determine optimum process conditions for the injection molding of a special part. Because of the complication of the injection molding process and multiplicity of parameters and their interactive effects on one another, analytical modeling of the process is either impossible or difficult. Therefore Artificial Neural Network (ANN) is used for modeling the process. Process conditions data is needed for modeling the process by the neural network. After modeling step, the model is combined with the Genetic Algorithm (GA). Based on the injection molding goals that have been turned into fitness function, the optimized conditions are obtained.
- انتشار مقاله: 06-02-1391
- نویسندگان: MOHAMMAD SALEH MEIABADI,Abbas Vafaei,Fatemeh Sharifi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Dysmenorrhea,Body Mass Index,Female Adolescents
- چکیده:
- چکیده انگلیسی: Background: Primary dysmenorrhea is a common problem among women, resulting in a decline in their performance level and quality of life. Previous studies have not indicated a definite relationship between body mass index (BMI) and dysmenorrhea. Therefore, this study aimed to determine the severity of dysmenorrhea and investigate its relationship with BMI among female adolescents in Hamadan, Iran.
Methods:This cross-sectional study was conducted on 579 single, female adolescents in schools of Hamadan, Iran in 2011. Students with primary dysmenorrhea (without any other conditions) were selected, using random cluster sampling. Demographic characteristics and menstrual cycle information were collected, using two separate questionnaires. BMI was recorded in all participants and visual analogue scale was applied for pain assessment. Chi-square, t-test, Fisher's exact test and logistic regression were used to examine the relationship between variables. Data were analyzed, using SPSS version 16. P-value less than 0.05 was considered statistically significant.
Results: The mean age, BMI and age at menarche in participants were 15.94±1.17 years, 21.16±3.36 kg/m2 and 12.92± 1.05 years, respectively. The frequency of dysmenorrhea was estimated to be 85.31%. The frequency and severity of dysmenorrhea was higher in the normal-weight group than other subjects. No relationship was seen between the severity and duration of dysmenorrhea with BMI. But dysmenorrhea had a significant relationship with age at menarche and premenstrual syndrome (p <0.05).
Conclusion: In this study, dysmenorrhea was highly prevalent among female adolescents. However, there was no significant association between BMI and dysmenorrhea. We recommend that future studies consider the confounding factors. Also, further research is required to find the relationship between the amount of body fat and dysmenorrhea.- انتشار مقاله: 29-04-1394
- نویسندگان: Batool Khodakarami,Seyede Zahra Masoomi,Javad Faradmal,Mojgan Nazari,Maryam Saadati,Fatemeh Sharifi,Maryam Shakhbabaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 18-10-1393
- نویسندگان: Mehrdad Afarid,Mohammad Hossein Nowroozzadeh,Feisal Rahat,Kazem Kamran,Fatemeh Sharifi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Childhood,Amblyopia,Primary vision care,Strabismus
- چکیده:
- چکیده انگلیسی: Primary vision care is recommended for infants and young children .Childhood is critical time to prevent loss of vision and to optimize treatment so some eye disorders in children must be diagnosed at this time.
To detect risk factors and visual abnormalities, the eye screening done by pediatricians and other primary care providers is necessary. The process that should occur at each child visit to identify those patients who require referral to ophthalmologist and can be a preventative health measure. Thus, it is important that pediatricians increased knowledge about the eye conditions that may affect their youngest patients. This article reviews the most important pediatric eye condition that primary care providers may encounter.- انتشار مقاله: 15-03-1394
- نویسندگان: Fatemeh Sharifi,Hamid Reza Rahimi,Arash Omid Tabrizi,Saeid Shahinfar,Alireza Attaei Nakhaie
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Rural,cervical cancer,Pap smear,health belief,counseling
- چکیده:
- چکیده انگلیسی:
Objective: Pap smear test is an appropriate screening method for early diagnosis of cervical cancer and reduction of mortality. This study targeted effects of group counseling based on the Health Belief Model on cervical cancer screening practices of Iranian rural women. Method: This quasi-experimental study was conducted on 80 rural women under coverage of the health care centers in rural areas in the city of Kabudrahang, Iran, in 2015. The data collection tool was a researcher-made questionnaire covering demographic information, Health Belief Model (HBM) constructs and screening performance. Data were collected using a multi-stage sampling method. Group counseling was conducted based on the Health Belief Model and the GATHER steps in three sessions for the intervention group. Counseling included an introduction to cervical cancer, disease symptoms, warning signs and prevention approaches. Pap smear testing in both intervention and control groups was evaluated two months after the group counseling. Results: Before the intervention, there was no significant difference between both groups in the HBM constructs and performance. After the intervention, a significant difference was seen in the perceived susceptibility (P<0.001), severity (P=006), benefits (P=012), barriers (P<0.001), and self-efficacy (P=002). Two months after the intervention, 17 patients (42.5%) in the intervention group, and 4 patients (10%) in the control group had undergone a Pap smear test (P<0.001). Conclusion: Design and implementation of counseling programs based on the HBM can modify the beliefs of rural women regarding cervical cancer screening and increase their performance.- انتشار مقاله: 18-11-1395
- نویسندگان: Parisa Parsa,Fatemeh Sharifi,Fatemeh Shobeiri,Manoocher Karami
- مشاهده