در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Pregnancy,Granulocyte Colony Stimulating Factor,Intracytoplasmic Sperm Injections
- چکیده:
- چکیده انگلیسی: Background:Expression of granulocyte colony stimulating factor (G-CSF) and its receptors in embryo and endometrium implicates the involvement of this glycoprotein on implantation process. In the present study, we aimed to evaluate the impact of routine use of subcutaneous administration of G-CSF on pregnancy outcomes in intracytoplasmic sperm injection (ICSI) patients. Methods: In this retrospective study, ICSI outcomes were compared between two groups of patients: the first group (n=108) who received subcutaneous G-CSF (300 mcg) two hours before the embryo transfer and the second group (n=110) who did not receive it. Pregnancy outcome was compared between the two groups. P-value<0.05 was considered statistically significant. Results:There was no significant difference between G-CSF and control groups with respect to the rate of implantation (respectively, 23%vs. 23%, p=0.49), chemical (respectively, 43.5%vs. 50%, p=0.34) and clinical (respectively, 40.7% vs. 46.4%, p=0.23) pregnancy. In logistic regression analyses, subcutaneous G-CSF administration was not associated with clinical pregnancy in both crude and adjusted odds ratios (OR) with 95% confidence interval (CI) (crude OR: 0.8, CI: 0.47-1.36, p=0.4, and adjusted OR: 0.99, CI: 0.48-2.07, p=0.99). Conclusion:In the present study, subcutaneous G-CSF did not improve pregnancy outcomes in patients undergoing ICSI; therefore, the routine use of this cytokine is not suggested for all patients.
- انتشار مقاله: 08-04-1398
- نویسندگان: Roya Kabodmehri,Marzieh Mehrafza,Tahereh Zare Yousefi,Sahar Saghati Jalali,Fatemeh Sedaghat,Elmira Hosseinzadeh,Azadeh Raoufi,Sajedeh Samadnia,Zahra Nikpouri
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Factor analysis,Breast cancer,Diet,Food,nutrients
- چکیده:
- چکیده انگلیسی: Objective: To explore the role of nutrient patterns in the etiology of breast cancer (BCa) among Iranian women.
Methods: The study included 134 newly diagnosed cases of BCa and 267 hospitalized controls. A validated
semi-quantitative food frequency questionnaire (FFQ) was used to assess dietary intake. Nutrient patterns were obtained
using principal component analysis using Varimax rotation and logistic regression was performed to estimate breast
cancer risk. Results: We identified 4 major nutrient patterns. First was high in consumption of vitamins B1, B2, B3, B5,
B6, B9, C, magnesium, iron, carbohydrate, fiber, selenium, zinc, protein, potassium, and calcium. The second nutrient
pattern included Vitamins B12, A and cholesterol, while the third featured vitamin D, EPA and DHA. The fourth was
characterized by vitamin E, MUFA and saturated fatty acids. After adjusting for age, patterns 1 and 3 were associated
with a lower risk of BCa (OR=0.51, 95% CI: 0.33- 0.80, P=0.003, OR=0.64, 95% CI: 0.42- 0.98, P= 0.04 respectively).
However, after further adjustment for all confounders in multivariate analysis, the association remained significant only
for pattern 1 (OR=0.52, 95% CI: 0.32- 0.82, P=0.006). Conclusion: Adherence to a nutrient pattern rich in vitamin B,
minerals and fiber is associated with a lower risk of breast cancer.- انتشار مقاله: 10-02-1397
- نویسندگان: Samira Sadat Fereidani,Hasan Eini-Zinab,Zeinab Heidari,Saba Jalali,Fatemeh Sedaghat,Bahram Rashidkhani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Dietary Inflammatory Index,Case-control
- چکیده:
- چکیده انگلیسی: Background: In Iran, colorectal cancer (CRC) is the third and fourth leading cause of cancer incidence among men
and women, respectively. Diet and inflammation have been suggested as important risk factors for CRC. We examined
the association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Iran.
Methods: This study included 71 CRC cases and 142 controls hospitalized for acute non-neoplastic diseases. DII
scores were computed from dietary intake assessed by a previously validated food frequency questionnaire. Logistic
regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) adjusted for age, sex,
education, energy intake, exercise, body mass index (BMI), smoking, family history of cancer, and history of aspirin,
acetaminophen, and multivitamin use. Results: Subjects with higher DII scores (i.e., indicating a more pro-inflammatory
diet) had a higher odds of CRC with the DII being used as both a continuous variable (OR continuous = 2.20, 95% CI:
1.22-3.87) and as a categorical variable (OR tertile 3 vs tertile1 = 2.47, 95%CI: 1.10-5.55). Conclusion: These results
indicate that a pro-inflammatory diet is associated with increased odds of CRC in this Iranian population.- انتشار مقاله: 28-12-1396
- نویسندگان: Nitin Shivappa,James R Hebert,Susan E Steck,Akram Safari,Fatemeh Sedaghat,Bahram Rashidkhani
- مشاهده