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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Ovary,Endometrium,Clear cell carcinoma,Napsin-A
- چکیده:
- چکیده انگلیسی: Background & Objective:
Clear cell carcinomas (CCC) differ from other types of ovarian and endometrial carcinomas in biology, behavior and response to chemotherapy. Histopathologic diagnosis may be challenging in some situations which necessitates immunohistochemistary (IHC) assessment. In this study we investigated the diagnostic utility of Napsin-A in diagnosis of ovarian and endometrial CCCs.
Methods:
Ovarian and endometrial CCC samples from 2013 to 2018 in 3 general and women’s hospital in Tehran were re-evaluated by 2 expert pathologists. Forty-two samples were included as case and 42 non-clear cell carcinomas (Non-CCC) of ovary and endometrium were selected as control group. Based on IHC study tumors with sum intensity and percentage score ≥2 (at least 1+ staining in more than 1% of tumor cells) were considered positive.
Result:
The prevalence of endometrial and ovarian CCC in the case group were 15 and 27 respectively. The tumors in the control group included 22 cases of endometrioid, 2 high grade papillary serous carcinoma (HGSC) of endometrium, 6 endometrioid and 12 HGSC of ovary. Napsin-A positivity was observed in 35 (83%) of CCCs while 7 (17%) samples including 3 out of 15 endometrial and 4 out of 27 ovarian CCCs were Napsin-A negative. No positive reaction was seen in control group. The overall accuracy, specifity and sensitivity of Napsin-A for diagnosis of ovarian and endometrial CCCs were 83%, 100% and 83%, respectively. Sensitivity for ovarian and endometrial CCCs were 85% and 80%, orderly.
Conclusion:
Napsin-A is an accurate and reliable marker for distinction of CCCs from non-CCCs in ovary and endometrium. A panel of antibodies may yield the highest diagnostic accuracy.- انتشار مقاله: 29-05-1398
- نویسندگان: Fatemeh Nili,Mansoureh Tavakoli,Narges Izadi-Mood,Hana Saffar,Soheila Sarmadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Colon,adenocarcinoma,malakoplakia
- چکیده:
- چکیده انگلیسی: Malakoplakia is a rare granulomatous disease of the genitourinary system. Gastrointestinal tract is the second most common site of involvement. It usually mimics a malignancy but its association with adenocarcinoma has been rarely reported.
A 59-year-old male patient with the history of weight loss and rectal bleeding for two months prior to administration was referred to our hospital. Pre-operative CT scan revealed a large sigmoid colon mass with the extension and invasion to the serosal surface as well as multiple regional metastatic lymph nodes. The patient underwent sigmoidectomy with the primary pathologic diagnosis of adenocarcinoma. Pathologic examination revealed a moderately differentiated adenocarcinoma invading peri-colic adipose tissue and inflammatory reaction compatible with malakoplakia at the invasive borders of the tumor with the extension to the serosal surface.
In the patients with gastrointestinal malakoplakia, the presence of possible adjacent malignancy should be screened. The possibility of over-staging should also be considered for adenocarcinoma cases in association with malakoplakia- انتشار مقاله: 09-09-1378
- نویسندگان: Fatemeh Nili,Nakisa Niknejad,Mohammad Shirkhoda
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Ovary,Neuroectodermal Tumor pPNET
- چکیده:
- چکیده انگلیسی: Peripheral primitive neuroectodermal tumor (pPNET) is a highly aggressive small round cell tumor belonging to PNET/Ewing sarcoma family. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare.
Herein we reported two cases of peripheral primitive neuroectodermal tumors of ovary in two patients with different clinical presentations. Definite diagnoses were made based on the histomorphology and immunohistochemistry
results.
With respect to different clinical behaviors, treatment modalities and prognosis of peripheral primitive neuroectodermal tumors compared to other known ovarian neoplasms, it is essential to consider this entity as a differential diagnosis in ovarian tumors especially in young patients.- انتشار مقاله: 27-02-1396
- نویسندگان: Fatemeh Nili,Azadeh Sedighi Moghadam Pour,Hedieh Moradi Tabriz,Parisa Sedighi Moghadam Pour,Hana Saffar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Dysgerminoma,Microscopic Growth Pattern,Pseudopapillary,Macrofollicular
- چکیده:
- چکیده انگلیسی: ysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. In microscopic examination, the usual known growth patterns in tumor cells are solid, trabecular, insular and rarely pseudoglandular.
In this paper, we reported an advanced ovarian dysgerminoma with different microscopic patterns of growth, including pseudopapillary and macrofollicular structures, in an 18-year-old woman. The patient underwent staging laparotomy and is currently receiving chemotherapy.- انتشار مقاله: 25-06-1395
- نویسندگان: Fatemeh Nili,Niusha Noubari,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality Control,Real-Time Polymerase Chain Reaction,Hepatitis B,Virus Load
- چکیده:
- چکیده انگلیسی: Background and Objectives: HBV DNA monitoring is important in management of chronic viral hepatitis B infection. HBV DNA measurements are carried out over period of months to years. So the analytical system must be stable and reproducible. The aim of this study was to determine the performance characteristics and to plan a statistical quality control system of a laboratory-developed real-time quantitative PCR assay for HBV DNA quantification. Methods: Values of systematic and random error at two clinical decision points;4.2 Log IU/mL (20000 IU/mL) and 3.2 Log IU/mL (2000 IU/mL) were determined. Candidate quality control procedures were selected and performance of the method by application of normalized operational process specification (OPSpecs) charts was determined. Results: The performance of the assay at level of 4.2 Log IU/mL and 3.2 Log IU/mL were excellent and good respectively. Moreover, a13.5S rule with two measurements offered 90% probability of error detection at level of 4.2 Log IU/mL, while no rule offered 90% probability of error detection at level of 3.2 Log IU/mL. Conclusion: Minimizing the formation of primer-dimer and nonspecific products and concentrating the target DNA during the purification process are proposed for accurate quantitative PCR particularly when CT values are high.
- انتشار مقاله: 24-03-1392
- نویسندگان: Fatemeh Nili,Reza Shahsiah,Farid Azmoudeh Ardalan,Mohsen Nassiri Toosi,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cutaneous melanoma,lymph node ratio,lymph node dissection
- چکیده:
- چکیده انگلیسی: Objective: Lymph node ratio (LNR) is defined as the ratio of the number of metastatic lymph nodes to the dissected
lymph nodes. LNR is a prognostic factor for many tumor types. The present study aimed to evaluate the prognostic
value of LNR in melanoma. Methods: This retrospective cohort study was conducted on 123 patients with stage III
cutaneous melanoma. Multivariate Cox proportional hazards model was used to evaluate the correlations between LNR
and other clinicopathological factors associated with survival. The patients were divided into four groups in terms of
the LNR, including groups A (LNR≤0.18), B (0.180.625). Results:
Initially, LNR was evaluated as a continuous quantity associated with survival. In the univariate analysis, a significant
correlation was observed between LNR, overall survival (OS), and disease free survival (DFS). Meanwhile, the only
association observed in the multivariate analysis was between LNR and OS. Increased LNR from group A to group D
reduced OS from 46 (±44.09) to 22.5 (±16.33) months (P=0.022). According to the multivariate analysis, prognostic
factors in OS were tumor thickness, American joint committee of cancer (AJCC) N stage, interferon administration,
and undergoing chemotherapy. Conclusion: According to the results, LNR could be used as an independent prognostic
factor for estimating the survival of patients with stage III cutaneous melanoma also designing an effective adjuvant
treatment protocol for these patients.- انتشار مقاله: 21-03-1397
- نویسندگان: Abolfazl Salari,Fatemeh Nili,Amir Mohsen Jalaeefar,Mohammad Shirkhoda
- مشاهده