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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: rosacea,Demodex folliculorum
- چکیده:
- چکیده انگلیسی: Background and Objective: Rosacea is a common and ill-defined disease and Demodex folliculorum has been reported in rosacea in a number of clinical studies. Since demodex mite is present in many healthy individuals, the mite may have a pathogenic role only when it is present in high densities. Therefore, in this study, the possible role of demodex folliculorum and the importance of mite density were investigated using an elliptical incisional skin biopsy technique. Materials and Methods: Thirty-nine patients with rocacea, twenty-five females, 14 males, and 41 age- and sex-matched healthy individuals as control were included in the study. With the incisional skin biopsy of face, we studied six sections of each sample. We also studied the number of follicles, mite density, epidermal changes, solar elastosis, inflammatory cells in the dermis and their pattern, granuloma formation, and vascular changes. Results: Varying degree of vasodilatation, solar elastosis, and inflammatory infiltrate were found in all patients. The infiltrate was lympho-histiocytic in 29 cases, lympho-plasmacytic in 6 cases, neutrophilic, especially around hair follicles in 2 cases, and eosinophilic infiltration mixed with mononuclear cells in 2 cases. The number of D. folliculorum was statistically significant. There was also a significant difference between males and females regarding the number of mite in rosacea in relation to age (p = 0.047). There was also granuloma around appendages in 3 cases and granuloma around hair follicle in 2 cases. One case in the latter group had degenerated demodex cuticle. Conclusion: Rosacea is a multifactorial disease and high densities of demodex are important in the form of hypersensitivity reaction to antigens or granuloma formation in response to its cuticle or destructed hair follicles. The individual properties may modify the severity of inflammatory response to demodex.
- انتشار مقاله: 06-07-1393
- نویسندگان: Alireza Monsef,Fatemeh Eghbalian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: immunohistochemistry,Breast,P53 protein,Nucleolus Organizing Regions
- چکیده:
- چکیده انگلیسی: Objective: Breast cancer comprise approximately one third of malignant cases in women and is considered as the most common invasive condition in women at an age range of 15-54 years and as the second most prevalent cause of mortality at an age range of 55-74 years. Tumor inhibiting factor p53 is a vital homeostatic regulator and its inactivation at the related gene or molecule could lead to tumor growth and development in various tissues. Therefore, in this research study it was tried to evaluate the diagnostic methods Ag-NOR and p53 immunohistochemistry in malignancy of mammary gland using cytochemical staining methods and its relationship with tumor grade. Materials and Methods: In this research study, 50 referred breast specimens to Deaprtment of Pathology (Sina Hospital, Hamedan) were studied. They were processed as usual and 3 micrometer sections were prepared from related blocks. Then, staining methods for nucleolus organizing regions (Ag-NOR) and p53 immunohistochemistry were applied. Out of these specimens, 41 had malignancy (40 cases of invasive ductal carcinoma and 1 case of invasive lobular carcinoma) and 9 cases were normal. The latter cases were compared with malignant ones. Tumor grade in studied individuals was I (3 cases; 7.3%), II (23 cases; 56.1%), and III (15 cases; 36.6%) respectively. Results: Statistical analysis of data showed that there is only a significant difference regarding frequency distribution of cluster shape and there is no such difference for satellite shape, satellite size, and cluster size. In addition, staining intensity for p53+, p53++, and p53+++did not show any significant difference in various grades of the disease. Using Spearman regression analysis, it was found out that there was a relationship between p53 negative and p53+ (r = 0.723) (p<0.01) and between p53+ and p53++ (r = 0.78). Furthermore, it was found out that a higher expression of p53 protein is negatively correlated with darklystained granules using silver nitrate method. Conclusion: These findings showed that higher expression of p53 protein is negatively correlated with darkly-stained granules using Ag-NOR method and this may indicate its antitumor activity. It appears that this method is an essential tool for evaluation of normal and malignant cases of breast tissue regarding its replication pattern and intensity and expression of those chromosomal segments which are involved in encoding of ribosomal RNA.
- انتشار مقاله: 05-07-1393
- نویسندگان: Alireza Monsef1,Fatemeh Eghbalian,S. Mahmoud Hessinipanah,Mohammad Abbasi4,Hossein Mahjoub
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 23-06-1392
- نویسندگان: Fatemeh Eghbalian,Farnaz Monsef,Nazanin Alam Ghomi,Alireza Monsef
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Hyperbilirubinemia,Phototherapy,Neonatal Jaundice,Transcutaneous bilirubin
- چکیده:
- چکیده انگلیسی: Background
Neonatal jaundice is a common condition. Total serum bilirubin (TSB) measuring is standard for bilirubin testing, while transcutaneous bilirubin (TcB) is an alternative method. We aimed to evaluate the correlation between TSB and TcB in term and preterm neonates.
Materials and Methods
This prospective cross-sectional study was conducted to on 93 term and preterm neonates in Fatemieh Hospital in 2018, Hamadan, Iran. The samples were categorized into two groups, including term and preterm icteric neonates. Neonates were evaluated to determine the necessity of bilirubin estimation with TSB measurement. After the confirmation of jaundice, the blood samples obtained were sent to the laboratory for bilirubin estimation, and at the same time, the TcB measurement was performed by the bilirubinometer. Selectra X-L was utilized by which the blood samples were analyzed through the dichloroanilin method. The Pearson correlation coefficient was used to evaluate the relationship and stringency of the correlation between the approaches.
Results
In general,61% and 38% of neonates were boys and girls, respectively. Before phototherapy, the TSB values were lower than TcB estimations in term and preterm neonates. The estimated Pearson correlation coefficients were obtained at r=0.729 (p <0.001), and r=0.802 (p <0.001) in term and preterm neonates, respectively. After phototherapy, contrary to the obtained results before phototherapy, the TSB concentration was higher than TcB concentrations. The difference between the measured values of the two approaches was more significant in term neonates. The Pearson correlation coefficient estimations were r=0.804 (p <0.001), and r=0.901 (p <0.001) in term and preterm neonates, respectively.
Conclusion
Based on the results, there was a significant correlation between the values of TSB and TcB in term and preterm neonates.- انتشار مقاله: 05-01-1399
- نویسندگان: Maryam Shokouhi,Behnaz Basiri,Mohammad Kazem Sabzehei,Fatemeh Eghbalian,Abbas Moradi,Hiva Ghadernejad,Fatemeh Haghighat Taleb
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: neonate,Neonatal Intensive Care Unit,Mechanical Ventilation,outcomes
- چکیده:
- چکیده انگلیسی: Background
Many neonates admitted to Neonatal Intensive Care Unit (NICU) need mechanical ventilation for recovery. This study was designed to evaluate the short-term outcome of mechanically ventilated neonates admitted to NICU.
Materials and Methods
In this descriptive cross-sectional study, all the neonates in need of mechanical ventilation in NICU of Besat Hospital, Hamadan, Iran, were enrolled for one year from September 2017 to September 2018. The selected data were of neonatal age at admission time, birth weight, gender, gestational age, indications of mechanical ventilation, lab results, length of hospital stay and the outcome of the disease were extracted from the medical file and analyzed using SPSS software (version 22.0).
Results
Of 141 mechanically ventilated neonates, 55.3% (n=78) were males. The mean of neonatal age, mean gestational age and mean birth weight were, 4.67 ± 6.58 days, 35.51 ± 3.88 weeks, and 2779.37 ± 827.06 g, respectively. RDS (58.9%) was the most common indication for mechanical ventilation. The overall rate of neonatal recovery was 51.8%. The results of unilabiate analysis showed a significant relationship between indications of mechanical ventilation, gestational age, neonatal birth weight, acidosis (pH <7.1), duration of mechanical ventilation, duration of hospitalization and the disease outcomes (P<0.05).
Conclusion
The results of this study showed that respiratory distress syndrome, low gestational age and birth weight, acidosis and duration of mechanical ventilation would lead to increased death in mechanically ventilated neonates.- انتشار مقاله: 14-04-1398
- نویسندگان: Amir Reza Monsef,Fatemeh Eghbalian,Mohammad Kazem Sabzehei,Elham Khanlarzade
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Newborn,Multiple Pregnancies,Perinatal outcome
- چکیده:
- چکیده انگلیسی: Background: Multiple pregnancies are responsible for the increased risk of maternal and neonatal morbidity and mortality. This study aimed to compare the perinatal outcome between multiple and singleton pregnancies.
Materials and Methods: This is a retrospective cohort study. A sample of 50 multiple birth neonates- born in Fatemieh Hospital of Hamadan, Iran in 2015- was selected using simple random sampling. Meanwhile, they were compared with 50 single birth neonates in the same center on gender, gestational age, mean birth weight, Apgar score, the use of Assisted Reproductive Techniques (ART), delivery method, cause of neonatal admission, duration and short outcome of neonatal hospitalization. The data were collected from the medical files of neonates and their mothers. The data were analyses using SPSS version 16.0 software.
Results: In this study, 100 neonates (50 single births and 50 multiple births) were compared. The mean gestational age and mean birth weight of multiple births were lower than that of single births (P<0.05). The frequency of low birth weight was 4%, 95.5%, and 100% among the single births, twins, and triplets, respectively. A significant difference was also found between multiple and single births on 1-Minute and 5-Minute mean Apgar scores, neonatal hospitalization after birth, hyperbilirubinemia, respiratory distress syndrome (RDS), the need for mechanical ventilator, antibiotics intake and phototherapy (P<0.05). Frequency of gestational diabetes and preeclampsia were greater in multiple pregnancies than single ones; however, the difference was not significant (P>0.05). A significant difference was found on the frequency of in vitro fertilization (IVF) method, rate of cesarean section and preterm delivery (P<0.05).
Conclusion: In this study, multiple pregnancies were associated with maternal complications including preterm delivery and the increased cesarean section rate, and neonatal complications such as low birth weight, prematurity and increased rate of neonatal hospitalization that increases risk of perinatal morbidity and mortality.- انتشار مقاله: 26-02-1396
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Fatemeh Eghbalian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Restricted fluids volume,Standard fluids volume,Transient tachycardia of the newborn
- چکیده:
- چکیده انگلیسی: Background
Transient tachypnea of the newborn (TTN) is one of the most common neonatal respiratory disease and its symptoms usually begins in the first few hours after birth. The volume of fluid intake according to the neonate's conditions varies. We aimed to compare the restricted fluids volume with standard fluids volume in treatment of neonates with TTN.
Materials and Methods: This clinical trial was performed on 80 neonates with a diagnosis of TTN admitted in the Neonatal intensive care unit (NICU) of Fatemiyeh Hospital and Beasat Hospital of Hamadan Medical University in Iran. Patients were randomly divided to standard fluids volume (control = 40), and restricted fluids volume treatment groups (case = 40). The hospitalization duration, oxygen therapy duration as well as the number of days need for oxygen with hood; Nasal continuous positive airway pressure (NCPAP), and mechanical ventilation therapy was recorded. After data collection, the data were statistically analyzed via SPSS software (version 21.0).
Results: The subjects were 30 (37.5%) females and 50 (62.5%) males (62.5%) with an average gestational age of 38.12(±1.07) weeks.The main aim from this interventional study was effect of restricted fluidtherapy on management of TTN in NICU section. The hospitalization duration, oxygen therapy duration and need for oxygen therapy with hood in the intervention group were significantly lower than the control group (P<0.05), but need for mechanical ventilation and need for NCPAP were not significantly different between the two groups (P>0.05).
Conclusion
TTN treatment with restricted fluids volume, compared with standard volume of fluids, significantly reduces the need for respiratory supports as well as the duration of hospitalization in the NICU section.- انتشار مقاله: 18-12-1396
- نویسندگان: Fatemeh Eghbalian,Mohammad Kazem Sabzehei,Nezamedin Emamzadeh,Maryam Shokouhi,Behnaz Basiri,Javad Faradmal,Jamileh Salavati
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,mortality,Risk Factor,neonates,NICU
- چکیده:
- چکیده انگلیسی: Background
Advances in the perinatal and neonatal cares have brought about considerable reductions in the neonatal mortality. The present study aimedto determine the disease patterns, outcomes and factors influencing the neonatal mortality in single neonatal intensive care unit.
Materials and Methods
This descriptive research was retrospective and cross-sectional in type. The study population enrolled all neonates who had been hospitalized in the neonatal intensive care unit (NICU) of the Besat hospital, Hamadan city, Iran, for a period of one year from October 1, 2015 to September 31, 2016 and the mothers and infants information (such as maternal diseases, delivery mode, neonatal age, birth weight, the causes and duration of hospitalization) were extracted from the Medical records and analyzed using SPSS software version 16.0
Results
The study population included 600 infants and 13% (78) of whom were died. The results of the multivariate logistic regression analysis for the risk factors associated to the neonatal deaths indicated that there was a significant relationship between neonatal deaths and the use of mechanical ventilation, gastrointestinal bleeding, birth weight less than 2500 grams, positive urine cultures, need for surgery, administration of dopamine, anticonvulsant drugs, and surfactant (P<0.05).
Conclusion
The present study indicated that sepsis, surfactant administration and ventilator use significantly influence neonatal death; additionally, to underlying diseases, the occurrence of complications and their number increase the probability of neonatal deaths.- انتشار مقاله: 23-01-1397
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Fatemeh Eghbalian,Mohammad Hossein Eslamian
- مشاهده