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- جایگاه : پژوهشی
- مجله: Research Journal of Pharmacognosy
- نوع مقاله: Journal Article
- کلمات کلیدی: essential oil,Herbal Medicine,Giardia lamblia,Cysts,Entamoeba histolytica
- چکیده:
- چکیده انگلیسی: Background and objectives: Giardiasis and amoebiasis are two common diseases in human societies which make increasing problems for the health managing systems. In the present study, the antiparasitic activity of Allium sativum, Artemisia sieberi, Zatraria multiflora, Chenopodium botrys and Eucalyptus globulus essential oils on Giardia lamblia cysts and Entamoeba histolytica trophozoites were investigated in vitro. Methods: Giardia lamblia cysts and E. histolytica trophozoites were isolated from infected sample stools. The parasites were treated by four concentrations (0.2, 0.1, 0.01 and 0.001 µg/mL) of essential oils, separately for 30 min at 37 °C. Results: Theessential oils at the concentration of 0.1 and 0.2 µg/mL indicated appreciate parasiticidal effect (p <0.05). Eucalyptus globulus had maximum efficacy on both G. lamblia and E. histolytica with mortality rates of 79.7% and 87.6% within 30 min. Conclusion: All essential oils showed potent anti-giardiasis and anti-amoebiasis activity. Also, E. globulus with the highest efficiency could be considered as anti-protozoa medication to use an adjunct or primary therapy.
- انتشار مقاله: 26-10-1397
- نویسندگان: Mohammad Azadbakht,Aroona Chabra*,Ali Saeedi Akbarabadi,Mohammad Hossein Motazedian,Taha Monadi,Fatemeh Akbari
- مشاهده
- جایگاه : پژوهشی
- مجله: Quarterly Journal of Applied Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Chromium oxide,Transmittance,Atomic Force Microscopy,Sputtering,Annealing time
- چکیده:
- چکیده انگلیسی: Chromium oxide (α-Cr2O3) thin films were prepared using thermal annealing of chromium (Cr)
films deposited on quartz substrates by direct current (DC) magnetron sputtering. The annealing
process of the films was performed for different times of 60, 120,180 and 240 min. The influence
of annealing time on structural, morphological and optical properties of the prepared films was
investigated by different analysis including X-ray diffraction (XRD), atomic force microscopy
(AFM) and spectrophotometry. The XRD patterns showed that upon thermal annealing the Cr
films transformed to (α-Cr2O3) and the annealing time has a profound effect on crystalline
structure of chromium oxide films. According to AFM results, the films surface morphologies
were strongly dependent on annealing time and an increase in annealing time led to an increase
in the grain size as well as in the surface roughness. The transmittance of the as deposited film
was found very low and it improved after annealing.
- انتشار مقاله: 03-10-1396
- نویسندگان: Fatemeh Hajakbari,Alireza Hojabri
- مشاهده
- جایگاه : پژوهشی
- مجله: Quarterly Journal of Applied Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: layered structure,Thermal oxidation,Thin film,Structural Properties,MoO3
- چکیده:
- چکیده انگلیسی: Molybdenum oxide (α-MoO)thin films were prepared on quartz and silicon substrates by thermal oxidation of Mo thin films deposited using DC magnetron sputtering method.
The influence of thermal oxidation times ranging from 60-240 min on the structural and morphological properties
of the preparedfilms was investigated using X-ray diffraction, Atomic force microscopy and Fourier transform infrared
spectroscopy. The XRD results revealed that the as deposited film was amorphous while those formed at thermal
oxidation times between 60-180 min exhibited polycrystalline orthorhombic molybdenum oxides.
The presence of (0k0) reflections in XRD patterns indicated the layered structure of α-MoO. Also the surface morphology
of the films isdependent on the thermal oxidation times. The FTIR spectrum confirmed the formation of MoO3 and the
peak at 992.53 cm-1 implythelayered structure of α-MoO3.- انتشار مقاله: 07-10-1394
- نویسندگان: Alireza Hojabri,Fatemeh Hajakbari,Yalda Ghodrat
- مشاهده
- جایگاه : پژوهشی
- مجله: Quarterly Journal of Applied Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Annealing,CuO,DC magnetron sputtering,Structural and Morphological properties
- چکیده:
- چکیده انگلیسی: In the present work, cupric oxide (CuO) films were obtained through thermal annealing of the copper (Cu) films deposited on quartz substrates by DC magnetron sputtering method. The annealing was performed in air atmosphere for different times ranging from 60-240 min at temperature of 400 ºC. The influence of annealing times on structural and morphological properties of the films was investigated by different analyses. The XRD results showed that the as-deposited film was Cu, while those annealed at different times were composed of CuO. By increasing annealing times up to 180 min, the intensity of CuO diffraction peaks increased and further enhancement of annealing times led to decrease of the crystallinity. Also, the AFM images of the films conformed the dependence of surface morphology to annealing times.
- انتشار مقاله: 19-08-1394
- نویسندگان: Alireza Hojabri,Fatemeh Hajakbari,Masoumeh Najarsadeghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Quarterly Journal of Applied Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Optical properties,Structural Properties,AlN,Ion beam sputtering
- چکیده:
- چکیده انگلیسی: Aluminum nitride (AlN) thin films have potential applications in microelectronic and optoelectronic devices. In this study, AlN thin films with different thicknesses were deposited on silicon substrate by single ion beam sputtering method. The X-ray diffraction (XRD) spectra revealed that the structure of films with thickness of - nm was amorphous, while the polycrystalline hexagonal AlN with a rough surface was observed at a thickness of nm. Also, the formation of AlN in amorphous films is identified by Fourier transform infrared (FTIR) spectroscopy. Atomic force microscopy (AFM) study confirms that the surface roughness and average grain size of films increased with film thickness.
- انتشار مقاله: 20-08-1394
- نویسندگان: Fatemeh Hajakbari,Alireza Hojabri,Majid Mojtahedzadeh Larijani
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: hypertension,Arterial Pressure,Pulmonary Artery
- چکیده:
- چکیده انگلیسی: Pulmonary arterial hypertension (PAH) is characterized by the mean pulmonary artery pressure of more than 25 mmHg and pulmonary artery wedge pressure of less than 15 mmHg evidenced by right-heart catheterization. In the classification of PAH, some subgroups are defined as primary or secondary PAH based on the underlying etiologies of the disease. Early episodes of PAH have been reported to occur at younger ages and in women in idiopathic or familial forms with the survival rate of 1-3 years. According to recent registries, the affected patients are older and have better survival rates. Some of the key elements in the pathophysiology of PAH include intima and media proliferation, vascular remodeling, and blood coagulation, which could increase the defiance of pulmonary vascularity, so that the cellular and molecular pathways would be able to induce PAH through specific mechanisms. Although no pathognomonic signs and symptoms have been reported in the literature, the most prominent manifestations of PAH are associated with disorders such as heart failure. Currently, PAH is known as a severe and occasionally life-threatening multifactorial clinical condition. Considering endothelial dysfunction, vasoconstriction, inflammatory reactions, and platelet aggregation as the main pathophysiological arms of the disease, specific treatment approaches have been proposed to inhibit these manifestations. These methods result in the effective treatment response, as well as the proper early and late outcomes of PAH. Due to the high incidence of cardiovascular diseases and the associated progressive life-threatening conditions, such as heart failure and PAH in the Iranian population, identification of the etiological, pathophysiological, diagnostic, and novel therapeutic approaches for PAH is essential to the proper management of this clinical condition.
- انتشار مقاله: 02-04-1395
- نویسندگان: Samaneh Sajjadi,Sepideh Hejazi,Ghazaleh Azami,Mina Akbari,Fatemeh Akbari
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: hypertension,Arterial Pressure,Pulmonary Artery
- چکیده:
- چکیده انگلیسی: Pulmonary arterial hypertension (PAH) is characterized by the mean pulmonary artery pressure of more than 25 mmHg and pulmonary artery wedge pressure of less than 15 mmHg evidenced by right-heart catheterization. In the classification of PAH, some subgroups are defined as primary or secondary PAH based on the underlying etiologies of the disease. Early episodes of PAH have been reported to occur at younger ages and in women in idiopathic or familial forms with the survival rate of 1-3 years. According to recent registries, the affected patients are older and have better survival rates. Some of the key elements in the pathophysiology of PAH include intima and media proliferation, vascular remodeling, and blood coagulation, which could increase the defiance of pulmonary vascularity, so that the cellular and molecular pathways would be able to induce PAH through specific mechanisms. Although no pathognomonic signs and symptoms have been reported in the literature, the most prominent manifestations of PAH are associated with disorders such as heart failure. Currently, PAH is known as a severe and occasionally life-threatening multifactorial clinical condition. Considering endothelial dysfunction, vasoconstriction, inflammatory reactions, and platelet aggregation as the main pathophysiological arms of the disease, specific treatment approaches have been proposed to inhibit these manifestations. These methods result in the effective treatment response, as well as the proper early and late outcomes of PAH. Due to the high incidence of cardiovascular diseases and the associated progressive life-threatening conditions, such as heart failure and PAH in the Iranian population, identification of the etiological, pathophysiological, diagnostic, and novel therapeutic approaches for PAH is essential to the proper management of this clinical condition.
- انتشار مقاله: 02-04-1395
- نویسندگان: Samaneh Sajjadi,Sepideh Hejazi,Ghazaleh Azami,Mina Akbari,Fatemeh Akbari
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Physical Activity and Hormones
- نوع مقاله: Journal Article
- کلمات کلیدی: Aerobic exercise,Hippocampus,Cognitive function,Alzheimer’s disease,Tau
- چکیده:
- چکیده انگلیسی: Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is characterized by a gradual loss of memory and cognitive function. Tau hyperphosphorylation and aggregation is major proximal causes of neuron loss in AD pathogenesis. Physical exercise may be an important adjunct to pharmacological treatment of AD, but the effects of aerobic exercise on tau gene expression are not well known. Thus, the purpose of present study was to determine the effects of aerobic exercise on tau gene expression in rats with trimethyltin (TMT) model of AD.
Material & Methods: In this experiment, Thirty tow mature Sprague-dawley male rats were subjected to Alzheimer’s disease through intraperitoneally injection of 8 mg/kg TMT and then were divided into (1) control, (2) Alzheimer-infected control group, (3) endurance training, and (4) sham to study the impact of the disease on the variables. The rats in the endurance training group ran on a rat treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. To analyze the results of the tests, one-way ANOVA and Tukey post hoc test were run using SPSS.
Results: The results indicated that TMT injection increases the tau gene expression in the Alzheimer-infected control group. No significant differences were observed between sham and control groups. TMT rats had increased levels of tau gene expression that were significantly ameliorated by exercise (P<0.05).
Conclusions: Our results suggest that aerobic exercise is a feasible intervention for delaying disease progression in AD.- انتشار مقاله: 06-01-1399
- نویسندگان: Fatemeh Akbari,Mehrzad Moghadasi,Sirus Farsi,Mohammad Amin Edalatmanesh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Oral Health and Oral Epidemiology
- نوع مقاله: Journal Article
- کلمات کلیدی: Absorption,Radiation,Cone-beam computed Tomography,Radiation Dosimeters,Panoramic Radiography
- چکیده:
- چکیده انگلیسی: BACKGROUND AND AIM: Due to increasing use of X-rays in diagnosis and treatment of diseases, this study aimed to measure and compares the absorbed dose in a number of sensitive organs of head and neck in different radiographic techniques.METHODS: Thermoluminescence dosimeter (TLD) and a male equivalent RANDO phantom were used to measure the absorbed dose in organs. The dosimeters were set in certain sites of phantom related to eye, parotid, thyroid gland, occipital area and temporomandibular joint (TMJ). Panoramic and Caldwell techniques with two different exposure conditions as well as Waters technique with three different exposure conditions were performed. Cone-beam computed tomography (CBCT) was applied in low and normal resolutions with different field of view (FOV), and the mean absorbed dose was calculated and compared by the dosimeters related to each of the organs.RESULTS: The panoramic imaging technique revealed the lowest dose for the eyes, but interestingly higher doses for the parotid gland and the occipital area. In total, Waters and Caldwell imaging techniques indicated that the occipital area and the parotid gland absorbed a higher dose than other organs. In the majority of CBCT scans the parotid region received the highest dose. However, during sinus CBCT (both in low-dose and high-dose modes), the TMJ and eye areas absorbed the highest dose. Investigation of the use of thyroid shield on the absorbed dose in this organ in CBCT showed an average 22% reduction in dose.CONCLUSION: In total, panoramic, Waters and Caldwell imaging techniques indicated that the occipital area and the parotid gland absorbed a higher dose than other organs. In the majority of CBCT scans, the parotid region received the highest dose.
- انتشار مقاله: 27-03-1395
- نویسندگان: Seyed Hosein Hoseini-Zarch,Mohammad Taghi Bahreyni,Fatemeh Akbari,Nasim Khaki,Mona Poorazad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Class Switch Recombination,Hyper IgM Syndrome,Clinical Manifestation
- چکیده:
- چکیده انگلیسی: Background: Defects in B cell class switch recombination (CSR) are a heterogeneous and yet very uncommon group of disorders which all have a genetic basis uniformly leading to hyper IgM (HIgM) syndrome. Due to the rare frequency of these conditions, a very small number of case series have been conducted on the affected patients.
Objective: To shed some light on the morbidity and mortality regarding a relatively large cohort of diagnosed CSR defective Iranian patients.
Methods: This study was performed using demographic information, laboratory findings and clinical data obtained from an observation of 33 Iranian patients of different ethnicities referred from all medical centers of Iran to the Children’s Medical Center Hospital, pediatrics center of excellence, Tehran, Iran; of which 28 were males and 5 were females.
Results: Our patients mean age at the onset of symptoms was 1.8 ± 0.2 years; they were diagnosed with a mean delay of 4.4 ± 3.3 years and followed for a mean time of 5.7 ± 4.8 years. The most prominent clinical features observed were multi-organ infections, affecting mostly the respiratory system, followed by lymphoproliferative and autoimmune disorders, the latter being of much higher frequency (44%) in our study than the reported frequency in previous reports. The three year survival rate for our enrolled patients was 67.9%.
Conclusions: Based on our findings, the most common cause of death in HIgM patients is respiratory failure. The molecular mechanism behind the nature of the CSR defective patients in Iran is more compatible with autosomal recessive mutations rather than X-linked HIgM syndrome which is in contrast with other large cohorts of patients with CSR defect.- انتشار مقاله: 14-05-1395
- نویسندگان: Hassan Abolhassani,Fatemeh Akbari,Babak Mirminachi,Saeed Bazregari,Ehsan Hedayat,Nima Rezaei,Asghar Aghamohammadi
- مشاهده