در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,HER2,Reproductive,Tumor marker,tumor molecular subtypes
- چکیده:
- چکیده انگلیسی: Background: Due to wide clinical differences in the various pathological types of breast cancer and also close
associations between disease prognosis and molecular subtypes, relationships of the latter with traditional risk factors
have been suggested. Hence, the present study aimed to assess any associations. Methods: This bi-center cross-sectional
study was performed on 800 consecutive women with known breast cancer referred to two Comprehensive Cancer Centers
in Tehran between 2006 and 2016. Baseline information related to reproductive risk profiles as well as pathological
tumor diagnosis and molecular subtypes determined using immunohistochemical analysis by immune-staining for
ER, PR, and HER2 molecules were collected by reviewing hospital records. Results: Of 800 samples included for
immunohistochemical analysis, 314 (39.3%) were diagnosed as of Luminal A subtype, 107 (13.4%) as Luminal B
subtype, 153 (19.1%) as HER-2 over-expressing, and 226 (28.3%) as triple negative. Among all reproductive risk
factors initially assessed, young age was associated with HER-2 over-expression, greater tumor size and a history of
abortion with the luminal B subtype, lower age at pregnancy with the luminal A subtype, and lower gravidity and
a shorter duration of breastfeeding with the triple negative subtype. Conclusion: Each molecular subtype of breast
cancer in our population may be associated with specific reproductive risk factors.- انتشار مقاله: 07-02-1396
- نویسندگان: Nahid Nafissi,Maryam Faraji,Mostafa Hosseini,Leyla Shojaee,Fatane Ziaee,Mohamad Esmaiel Akbari,Seyed Hamzeh Mousavie
- مشاهده