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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,Papanicolaou Smear,Anal Neoplasms,Anal Canal Abnormalities,Cervical Intraepithelial Neoplasms
- چکیده:
- چکیده انگلیسی: Background: Anal cancer is uncommon. Although uncommon, the incidence of anal cancer has increased among
the general population of the United States and other countries over the past 30 years. We evaluated anal cytology in
women with the history of abnormal pap smear, cervical intraepithelial neoplasia, cervical cancer and high risk HPV
for anogenital dysplasia. Methods: In this cross-sectional study, 153 patients over the age of 21 years, referred to Imam
Hossein Hospital in 1395-1396 who were being monitored due to abnormal pap smear, cervical cancer, CIN and high
risk HPV, were evaluated with anal cytology for anogenital dysplasia. Results: 153 patients were enrolled in four
main groups. Among those with a history of abnormal pap smear (39 patients), only 25% of the patients with HSIL
had abnormal anal pap smear, and the rest of them had negative anal smear. Among those with a history of CIN (61
patients), patients with CIN III, 30.8% had abnormal anal smear, while the rest had a negative anal smear. Among those
with a high risk of HPV (23 patients), 50% of the patients with concurrent positive HPV 16 and 18 had anal abnormal
smear. Patients with a history of cervical cancer (30 patients) who had radiotherapy with or without surgery showed a
negative anal smear. The ratio of anal SIL positive of individuals with a sexual partner was only 1.9%, while this ratio
was 27.3% for those with more than one partner and this difference was statistically significant (P <0.0001). 15.4%
of smokers had positive anal SIL test result, while, only 2.9% non-smokers had the same result, and this difference
was statistically significant (P = 0.03). 20% of the patients who had anal intercourse showed a positive anal SIL score
result, compared to 1% for those who did not. This difference was statistically significant (P <0.0001). Conclusion:
Among people with a history of abnormal cervical pap smear, CIN, cervical cancer and high-risk HPV during the last
6 months, abnormal anal tests are most commonly seen in patients who had risk factors such as anal sex, cigarette,
multi partner etc. with high grade interepithelial squamous cervix such as HSIL, CIN III, HPV 16 and 18; more studies
in larger sample size are needed to have the better conclusion.- انتشار مقاله: 09-08-1396
- نویسندگان: Maryam Sadat Hosseini,Donya Khosravi,Farah Farzaneh,Abdalali Ebrahimi,Maliheh Arab,Tahereh Ashraf Ganjoie,Farzane Jamdar,Atefeh Moridi,Mohammad Chehrazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Optimal Debulking,Neoadjuant Chemotherapy,CA125,Prediction Model
- چکیده:
- چکیده انگلیسی: Background: Primary cytoreduction surgery followed by chemotherapy is the cornerstone treatment for epithelial
ovarian cancer (EOC). In patients with a low probability of optimal primary surgical debulking, neoadjuvant
chemotherapy (NACT) followed by interval debulking increases the chance of optimal surgery. The aim of this study
was to develop a model to identify preoperative predictors for suboptimal cytoreduction. Methods: Medical records
of patients with EOC who underwent primary cytoreductive surgery in a referral tertiary gyneco-oncology center
were reviewed from 2007 to 2017. Data were collected on a range of characteristics including demographic features,
comorbidities, serum tumor markers, hematologic markers, preoperative imaging, surgical procedures, and pathologic
reports. Univariate and multivariate analyses were performed to clarify the ability of preoperative factors to predict
suboptimal primary surgery. Results: The majority of patients (71.3%) who underwent primary cytoreductive surgery
were optimally debulked. Based on the Youden index, the best cut-off point for the serum CA125 level to distinguish
suboptimal debulking was 420U/ml with 0.730 (95%CI:0.559 to 0.862) sensitivity and 0.783 (0.684 to 0.862) specificity.
Multiple logistic regression results showed that serum CA125 level >420 U/ ml (p value <0.001), the presence of liver
metastasis on preoperative imaging (p value: 0.041) and ascites (p value: 0.032) or massive ascites (p value:0.010)
significantly increased the risk of suboptimal debulking (logit p = 2.36 CA125 level +1.85 Liverinvolvement +1.68
presence of Ascites+ 2.28 Massive Ascites). Conclusion:The present study suggests that a serum CA125 level >420 U/ml,
the presence of ascites or massive ascites and liver metastasis are strong predictors of suboptimal primary surgery in
cases of EOC. Based on the constructed model, with any of these 4 factors, the probability of suboptimal debulking in
EOC is more than 80%.- انتشار مقاله: 05-09-1396
- نویسندگان: Maliheh Arab,Farzane Jamdar,Maryam Sadat Hosseini,Robabe Ghodssi-Ghasemabadi,Farah Farzaneh,Tahereh Ashrafganjoie
- مشاهده