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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: adenoid cystic carcinoma,p63,matrix metalloproteinase,Mucoepidermoid carcinoma,Maspin
- چکیده:
- چکیده انگلیسی: Statement of the Problem: The tumor suppressor role of myoepithelial cells and related mechanisms in breast tumors are well understood. However, the role of these cells in salivary glands tumors is debatable.
Purpose: The present study was designed to determine the expression of p63, Maspin and Matrix metalloproteinase 2 (MMP-2) in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ADCC) of salivary glands due to various cellular differentiation and structure. The association between the expression of these markers and clinicopathologic features and myoepithelial differentiation were also evaluated.
Materials and Method: P63, Maspin and MMP-2 expression were immunohistochemically studied in 67 cases including35 cases of MEC and 32 cases of ADCC. The smooth muscle actin (SMA) staining was also applied to confirm the presence of myoepithelial differentiation. Data was analyzed using Chi-square test, Mann-Whitney U test and t-test.
Results: The expression of p63 (p = 0.009) and Maspin (p = 0.012) significantly differed between the study groups.P63 positive cells in MEC were negative for SMA staining in contrast to ADCC. Furthermore, the expression of P63 (p = 0.045) and Maspin (p = 0.019) significantly and inversely correlated with histologic grade in ADCC. Likewise, positive significant correlation was detected between histologic grade and expression of P63 (p = 0.018) and MMP-2 (p = 0.003) in MEC samples.
Conclusion: Ourfindings showed thatMEC is devoid of myoepithelial cells. The difference in expression of P63 and Maspin in ADCC and MEC highlighted the role and presence of myoepithelial cells in ADCC. Indeed, the high expression of P63 and Maspin in well differentiated ADCCs suggests the tumor suppressor effect of myoepithelial cells. Considering the association between the evaluated markers and histological grade, p63 in both tumors, Maspin in ADCC and MMP-2 in MEC may be efficient predictors of clinical behavior.- انتشار مقاله: 17-09-1397
- نویسندگان: Nasim Taghavi,Farzad Yazdani,Alireza Akbarzadeh Baghban,Soudabeh Sargolzaei,Parisa Kardouni Khozestani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,CD44,Tongue SCC
- چکیده:
- چکیده انگلیسی: Introduction:
90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis.
Materials and Methods:
Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody.
Results:
There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival.
Conclusion:
There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors.- انتشار مقاله: 06-02-1394
- نویسندگان: Reza Kaboodkhani,Ebrahim Karimi,Mohammad Taghi Khorsandi Ashtiani,Safoura Kowkabi,Mohammad Reza Firouzifar,Farzad Yazdani,Nasrin Yazdani
- مشاهده