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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Persian Gulf,Cytotoxic activity,Total phenolic content,soft corals,antioxidant DPPH photometric assay,Folin–Ciocalteu method
- چکیده:
- چکیده انگلیسی: Marine soft corals contain a variety of secondary metabolites with diverse, biological activities, including cytotoxic and anti-oxidant. The aim of this study was to evaluate the total phenolic content, antioxidant and cytotoxic activities of some soft corals of Persian Gulf including: Junceella juncea, Cavernularia sp., white Menella sp., brown Menella sp., Virgularia sp., Sinularia compressa, Sinularia variablis and Sinularia polydactyla were collected from Persian Gulf and extracted by maceration with methanol-ethyl acetate (1:1) solvent. The extract was evaporated and the total phenolic content was evaluated by using the Folin-ciocalteu reagent. The antioxidant activity of corals was tested by using DPPH photometric assay and cytotoxic activity of them against MCF-7 and OVCAR-3 cancer cell lines were performed. The cell survivals of MCF-7 and OVCAR-3 cell lines were decreased by increasing the concentration of the extracts. The brown Menella sp. showed the highest cytotoxic activity against MCF-7 with IC50 values of 325.45±2.57 µg/ml and S. polydactyla showed the highest cytotoxic activity against OVCAR-3 cell line with IC50 values of 260.99±7.93 µg/ml. White Menella sp. showed the highest antioxidant activity with IC50 values 0.056 µg/ml. Finally Cavernularia sp. had the most polyphenol content with 186.33 mg/L.
- انتشار مقاله: 23-04-1398
- نویسندگان: Afsaneh Yegdaneh,Elmira Mohammadi,Negin Mehdinezhad,Leila Shabani,Pardis Mohammadi Pour
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: essential oil,Disk diffusion,Chronic disease,Infection
- چکیده:
- چکیده انگلیسی: Background and aims: Tooth decay is one of the most common chronic diseases around the world and this problem is the result of variety of different bacteria. Streptococcus mutants is one of the most important bacteria which is related to this disease. Finding new effective antibacterial agents is an important area in bioscience for fighting and controlling bacterial infections. Essential oils are most important natural sources of antibacterial agents, particularly against drug-resistant bacteria.
Methods: The aim of this study was to evaluate and compare the antibacterial activity of three essential oils Mentha arvensis, Mentha piperita and Foeniculum vulgare Mill against Streptococcus mutants. Disk diffusion method was carried out and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured.
Results: The results showed that all three essential oils have antibacterial activity against S. mutants. With a constant concentration of 100 µg/µl, the efficiency of Mentha piperita and then Foeniculum vulgare Mill was higher than the efficiency of Mentha arvensis at all 3 given time points (24, 48 and 72 hours). The most effective MIC and MBC were related to Streptococcus mutants using Foeniculum vulgare essential oil which were equal to 8.4 and 14.9 µg/ml, respectively. MIC and MBC for Mentha piperita essential oil were measured 10.5 and 16.3 µg/ml, respectively.
Conclusion: The Essential oils used in present study with different components showed antibacterial activity and therefore they can be used as new antibacterial substances.- انتشار مقاله: 29-12-1395
- نویسندگان: Zahra Golestannejad,Shahin Gavanji,Elmira Mohammadi,Amir Motamedi,Mehdi Bahrani,Fatemeh Rezaei,Behrouz Larki,Amin Mojiri,Azizollah Bakhtari
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Dental caries,Streptococcus mutans,Essential oils,Antimicrobial
- چکیده:
- چکیده انگلیسی: Background and aims: One of the most common chronic diseases in the world is tooth decay. A variety of bacteria are involved in this disorder of which Streptococcus mutants is the most common. Essential oils are considered as new natural compounds for use in combating drug-resistant bacteria. This study was aimed to evaluate the antibacterial activity of some essential oils prepared from Eucalyptus caesia Benth, Cuminum cyminum L. and Satureja hortensis L. on S. mutants. Methods: In this study, essential oils were extracted by hydrodistillation method. E. caesia Benth, C. cyminum L. and S. hortensis L. were characterized by using gas chromatography‒mass spectrophotometry (GC‒MS). Antibacterial activity indices including minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and zone of inhibition for the above essential oils against Streptococcus mutans were determined using broth macro-dilution and disk diffusion methods. Data analysis was performed using one-way ANOVA and Tukey test. Results:Results showed that all three extracts had antibacterial activity against S. mutants. S. hortensis L. essential oil with the lowest MIC and MBC value (13.2 and 18.4 µg/ml, respectively) and the biggest inhibition zone showed the strongest antibacterial effect against S. mutants in all exposure times and at all concentrations, compared with two other essential oils. Furthermore, C. cyminum L. essential oil had higher anti-bacterial activity against S. mutant than E. caesia Benth essential oil. Conclusions:The essential oils used in the present study with different components showed antibacterial activity (especially S. hortensis L essential oil), and therefore they can be used as a new antibacterial substance. Keywords: Dental caries, Streptococcus mutans, Essential oils, Antimicrobial.
- انتشار مقاله: 20-02-1394
- نویسندگان: Zahra Golestannejad,Elmira Mohammadi,Amir Motamedi,Shahin Gavanji,Niloofar Fallah,Shervin Bagherie,Golshan Farzane,Milad Safaripour,Asana Vally,Mohsen Doost Mohammadi,Behrouz Larki,Azizollah Bakhtari
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Dental caries,Streptococcus mutans,Essential oils,Antimicrobial
- چکیده:
- چکیده انگلیسی: Background and aims: One of the most common chronic diseases in the world is tooth decay. A variety of bacteria are involved in this disorder of which Streptococcus mutants is the most common. Essential oils are considered as new natural compounds for use in combating drug-resistant bacteria. This study was aimed to evaluate the antibacterial activity of some essential oils prepared from Eucalyptus caesia Benth, Cuminum cyminum L. and Satureja hortensis L. on S. mutants. Methods: In this study, essential oils were extracted by hydrodistillation method. E. caesia Benth, C. cyminum L. and S. hortensis L. were characterized by using gas chromatography‒mass spectrophotometry (GC‒MS). Antibacterial activity indices including minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and zone of inhibition for the above essential oils against Streptococcus mutans were determined using broth macro-dilution and disk diffusion methods. Data analysis was performed using one-way ANOVA and Tukey test. Results:Results showed that all three extracts had antibacterial activity against S. mutants. S. hortensis L. essential oil with the lowest MIC and MBC value (13.2 and 18.4 µg/ml, respectively) and the biggest inhibition zone showed the strongest antibacterial effect against S. mutants in all exposure times and at all concentrations, compared with two other essential oils. Furthermore, C. cyminum L. essential oil had higher anti-bacterial activity against S. mutant than E. caesia Benth essential oil. Conclusions:The essential oils used in the present study with different components showed antibacterial activity (especially S. hortensis L essential oil), and therefore they can be used as a new antibacterial substance. Keywords: Dental caries, Streptococcus mutans, Essential oils, Antimicrobial.
- انتشار مقاله: 20-02-1394
- نویسندگان: Zahra Golestannejad,Elmira Mohammadi,Amir Motamedi,Shahin Gavanji,Niloofar Fallah,Shervin Bagherie,Golshan Farzane,Milad Safaripour,Asana Vally,Mohsen Doost Mohammadi,Behrouz Larki,Azizollah Bakhtari
- مشاهده