در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Medicinal and Chemical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Density functional theory,Phthalocyanine,Photosensitizer,Singlet molecular oxygen
- چکیده:
- چکیده انگلیسی: In this work, phthalocyanine and its OCH3 derivatives were investigated to see their photosensitization characteristics for producing singlet molecular oxygen, which is important in photodynamic therapy type-II. All structures were first optimized to achieve the minimized energy 3D models Subsequently, they were prepared for the photosensitization investigations. All the experiments were conducted based on the density functional theory calculations. The energy absorption and emission observed between the occupied and unoccupied molecular orbitals based on the required energy for excitation and the corresponding energy of emission. The results indicated that the OCH3 models could be expected to be safer than the original phthalocyanin by their required energy at longer wavelengths. The ratio of singlet molecular oxygen generation was found to be 1:1 for each of the OCH3 derivatives.
- انتشار مقاله: 21-02-1398
- نویسندگان: Ali Zare,Mahmoud Mirzaei,Mahboubeh Rostami,Elham Jafari
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Granular cell tumor,Breast granular mass,S100 positive tumors,Breast imaging
- چکیده:
- چکیده انگلیسی: Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of the breast clinically and radiologically, and the definite diagnosis especially in fine needle aspiration cytology (FNAC) is a great challenge. Granular cell tumor almost always has a benign clinical behavior and malignant transformation is seen in less than 1% of cases, which requires additional therapy other than local surgical resection. Here, we report a rare case of benign granular cell tumor of breast that should be differentiated from other breast neoplasms especially invasive carcinomas.
- انتشار مقاله: 21-10-1397
- نویسندگان: Elham Jafari,Hamid Tabrizchi,Forogh Mangeli,Hamid Zeynali Nezhad
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Myelolipoma,adrenal gland,Adrenalectomy
- چکیده:
- چکیده انگلیسی: Adrenal myelolipoma is a rare benign tumor that is composed of hematopoietic cells and mature fat. Mostly, these nonfunctioning tumors are distinguished incidentally during autopsy or radiologic investigations. Here, we report a case of 46-year-old man presented with nonspecific abdominal pain for one year, who had right adrenal mass with fat density detected by radiologic investigation. Histopathological assessment of right adrenalectomy specimen revealed the diagnosis of adrenal myelolipoma.
- انتشار مقاله: 11-02-1398
- نویسندگان: Elham Jafari,Hamid Pakmanesh,Ali Hadipour,Najmeh Sadat Fadaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastric cancer,Gene expression,IHC,Her-2/neu
- چکیده:
- چکیده انگلیسی: Background:In tumoral cells, the HER-2/Neu is an oncogene and overexpression would result in further membranous proteins. The role of this gene is known in ling and breast cancers. This study was undertaken to determine the HER-2/Neu overexpression in gastrectomy samples in patients with gastric cancer and its association with tumor histopathology prognostic factors. Methods: This cross-sectional study was conducted among 48 samples of gastric cancer under gastrectomy. The slides were prepared to assess HER-2/Neu stained by IHC method (Biogenax Kit and DAOK criteria). Statistical analysis was done using SPSS software version 20.0. Results: Out of 48 cases, 79.2% were males. The mean age was 59.93 ± 13.95 years and the mean tumor size was 5.5 ± 2.45 cm. Majority of cases were in anthrum and pylor (43.8%). Lauren class showed a higher frequency of intestinal type (72.9%). In surgery the majority of cases were found to be in T3 stage (87.5%). Her-2/Neu was positive in 10.4% of cases and it was negative in 89.6% of cases. Despite the higher rate of tumors with further expression of HER-2/Neu in those with a size over 5 cm and with vascular invasion, there was no significant association between Her-2/Neu and other variables (P > 0.05). Conclusion: According to the results of this study, overexpression of HER-2/Neu in gastric cancer is low (10.4%) and there is no significant association with other variables. It is suggested that further similar studies with a larger sample size be carried out to definitely determine the association between this marker and prognostic factors.
- انتشار مقاله: 01-02-1398
- نویسندگان: Mohammad Mahdi Hayatbakhsh Abbasi,Elham Jafari,Mohamad Javad Zahedi,Sodaif Darvish Moghaddam,Nasrin Naghibzadeh Tahami Zarandi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Benign prostate hyperplasia,Human papilloma virus,Prostate carcinoma
- چکیده:
- چکیده انگلیسی: Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than 100 types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-16 and HPV-18 have shown further association with cancer. Regarding the presence of E6 and E7 in HPV and ability for modification of basal epithelial cells, related role in prostate cancer (as well as cervical and genital malignancies) is hypothesized. The aim of this study was to determine the association of HPV-16 and HPV-18 with prostate cancer and malignancy degree. Methods: A total of 75 consecutive paraffin-embedded blocks including 50 samples with primary prostate cancer and 25 samples with benign prostate hyperplasia (BPH) as control were studied. Amplisense kit was used for replication at real-time polymerase chain reaction (PCR) to determine genotypes of HPV-16 and HPV-18. DNA purity was assessed by Nano Drop. Results: The results of real-time PCR demonstrated that none of the samples of BPH and prostate cancer had amplification of HPV DNA. Conclusion: The results revealed that HPV-16 and HPV-18 are not causes of prostate cancer.
- انتشار مقاله: 29-01-1396
- نویسندگان: Elham Jafari,Shariar Dabiri,Abbas Mortazaeizadeh,Ahmad Reza Sayadi,Sahar Amir Poor Rostami
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Adenoid Differentiation,Chondrosarcomatous Differentiation,Gliosarcoma
- چکیده:
- چکیده انگلیسی: A heterogeneous group of CNS tumors are characterized by mixed neuroepithelial and mesenchymal features. Glial tumors manifesting this phenomenon are referred to as gliosarcoma. These tumors are usually mistaken for cerebral metastases or meningioma at operation. Their histological studies have revealed an admixture of gliomatous and sarcomatous tissues, which leads to a biphasic pattern. The mesenchymal component can present in different forms such as fibrosarcoma, undifferentiated pleomorphic sarcoma, chondro-osteogenic, and myogenic differentiation, as well as angiosarcomatous and liposarcomatous types. Squamous differentiation, adenoid formations and glandular structures may also be displayed.
Herein, we report a rare case who was admitted to the emergency room with decreased consciousness resembling methadone poisoning. Clinical work-up showed a temporoparietal mass on radiological investigation. Histopathological evaluation of the brain mass revealed a gliosarcoma with adenoid formations and a mesenchymal component, which manifested as chondrosarcomatous differentiation. Immunohistochemical studies confirmed the histologic diagnosis through positivity for EMA, GFAP, S100, and vimentin expression in different components.- انتشار مقاله: 14-12-1398
- نویسندگان: Elham Jafari,Shiva Didehban,Shahriar Dabiri,Behshad Mofid
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Neuroendocrine tumor,head and neck neoplasms,Carotid body tumor
- چکیده:
- چکیده انگلیسی: Carotid body paraganglioma is a neuroendocrine neoplasm of the mandibular region. Due to its prominent stromal alternations, carotid body paraganglioma is a great emulator of other neoplasms in the head and neck region especially in metastatic tumors and its definite diagnosis is a great challenge. To the best of our knowledge, the most frequently reported variant is sclerosing and paraganglioma with a prominent lymphoplasmacytic infiltration is extremely rare. We report a rare case of a carotid body lymphoplasmacytic paraganglioma presented as a single asymptomatic mass of the right mandibular region in a 45-year-old woman. In order to exclude other possibilities, the use of immunohistochemistry is essential which shows a strong positive immunoreaction for chromogranin and synaptophysin. Surgical resection is the treatment of choice which is replaced with radiotherapy in contraindications. Overall, the tumor has a favorable clinical outcome.
- انتشار مقاله: 21-03-1398
- نویسندگان: Elham Jafari,Hamid Tabrizchi,Foroogh Mangeli
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognostic factors,Ascites,mast cell leukemia,systemic mastocytosis,multiple organ damage
- چکیده:
- چکیده انگلیسی: Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively.
We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involvement by diffused aggregates of oval- and spindle-shaped atypical mast cells, lacking mature mast cells and other hematopoietic cells. The mast cells were absent in peripheral blood smear. Further assessments showed positive reaction of mast cells metachromatic granules with Tryptase, Giemsa and Toluidine blue stains, the expression of CD117/KIT and CD45 by immunohistochemistery, and elevated level of serum Tryptase.
Radiologic investigations revealed generalized lymphadenopathy, and massive hepatosplenomegaly, followed by the cervical lymphadenectomy, and liver wedge biopsy. Suspicious peritoneal lesions were identified and underwent excisional biopsy. Microscopic evaluations showed lymph nodes and liver involvement by cancer cells and the same features in peritoneal seeding. Multiple organs damage progressed in few months and the patient died despite surgery and chemotherapy.
In conclusion, we report an extremely rarecase of aleukemic MCL with multiple organs damage such as liver, peritoneum, spleen, gastrointestinal tract and BM, presenting by ascites. According to this case and previous parallel studies, we suggest some clinicopathologic features in favor of poor prognosis, including the presence of multiple organs damage, hepatomegaly, ascites, peritoneal seeding, the absence of mature mast cells and other hematopoietic cells in the BM, and elevated serum Tryptase level.- انتشار مقاله: 07-10-1397
- نویسندگان: Elham Jafari,Ali Hadipour,Behjat Kalantari Khandani,Firoozeh Abolhasani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Prognosis,neoadjuvant therapy,Ki 67
- چکیده:
- چکیده انگلیسی: Background and objective:Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis.
Methods: This retrospective study was carried out on 55 consecutive patients with breast cancer referred to a Training Tertiary Healthcare Center in Kerman, Iran since 2009 to 2014. After diagnostic approval, the tissue samples of patients were examined for estrogen and progesterone receptors, ki67 and HER2-neu markers by using immunohistochemical staining. Then the patients were treated with 6 cycles of Neoadjuvant chemotherapy regimens by Doxorubicin and Taxans or 4 chemotherapy cycles, containing Anthracycline and Cyclophosphamide and 4 cycles of Paclitaxel. After mastectomy, their samples were reexamined for ki67 again and classified into three groups (low: ki67<15%), medium (Ki67 = 16-30%) and high (Ki67> 30%).
Results: Before chemotherapy, 54.5% of the patients had high expression of Ki67. But after chemotherapy, 52.7 of the patients had complete therapeutic response showing that the Ki67 level was reduced significantly (P=0.003).
Conclusion: Before and after Neoadjuvant chemotherapy, Ki67 measurements may be used as a predictive marker of therapeutic response.- انتشار مقاله: 29-06-1395
- نویسندگان: Vahid Moazed,Elham Jafari,Behjat Kalantari Khandani,Ali Nemati,Seyedamir Benrazavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Economic Review
- نوع مقاله: Journal Article
- کلمات کلیدی: Government expenditure,Keywords: Economic Growth,C13,Oil Revenue. JEL Classification: H51,H40
- چکیده:
- چکیده انگلیسی: E conomic growth is one of the goals of development in the economic plans of every country. Achieving self-development in OPEC member takes precise awareness of the amount and cause of the impact of economic variables on each other and it is, determining the policies and efficient, appropriate strategies for each case. Among these variables, oil revenues, total government expenditure, government expenditure for education, government expenditure for health, and economic growth could be mentioned. An examination of the trend of changes in health expenditure in Iran shows up until 2011. After that, there has been a leap in these expenditures. The share of government education expenditure in the total government budget in Iran has been showing a steady decline in these expenditures. panel data, we study the relationship between health expenditure and education expenditure and economic growth in OPEC countries and Iran from 2004 to 2016. Hence, the panel data method has been applied to estimate models and the panel VAR method has been applied to examine the causality relationships between variables. The results show a positive meaningful relationship between oil revenues, total government expenditure, government expenditure for education, government expenditure in health, and economic growth of OPEC countries and Iran. Furthermore, the result of the Granger Causality test suggests that there is a practical, mutual relationship between oil revenues and economic growth, total government expenditure and economic growth, and also a practical one-sided relationship of economic growth with government expenditure for education and also one-sided relationship of economic growth with government expenditure for health in OPEC countries and Iran.
- انتشار مقاله: 14-09-1397
- نویسندگان: Ebrahim Anvari,Abdol Majid Ahangari,Elham Jafari
- مشاهده