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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,Prognostic factors,Mean platelet volume,change-point analysis,tumor volume
- چکیده:
- چکیده انگلیسی: Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet
volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with
lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33
patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell
carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. The overall
survival was measured from the time of surgery to last observation or death. The tumor’s size was established based
on information from histopathology protocol by using model for the ellipsoid (V=4/3 π r abc). Results: KM median
survival time after surgery was 20 months (95% C.I. = 16–42). The survival time depends significantly on: Tumor
feature, MPV (p=0.03, p=0.04). Patients with normal PLT levels have longer survival time (median: 11 months) than
thrombocytosis group (9.5) (p=0.6). Following both the PLT and MPV, a change-point that is equal to approximately
18.5 cm3 (approx. 3.3 cm in diameter) stands for a segmented relationship between tumor volume and analyzed blood
indicators. Conclusions: After an overstepping of the change-point of tumor volume inflammatory processes start and
they are associated with poor prognosis. MPV may be a valuable biomarker for the diagnosis and follow up of various
types of carcinoma.- انتشار مقاله: 01-08-1396
- نویسندگان: Edyta Wolny-Rokicka,Jerzy Wydmański,Andrzej Tukiendorf,Piotr Mróz,Katarzyna Gramacka,Agnieszka Namysł-Kaletka,Jakub Lipiński,Agniszka Zembroń-Łacny
- مشاهده