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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,circulating prostate cells,neutrohil/lymphocyte ratio
- چکیده:
- چکیده انگلیسی: Introduction: An elevated serum PSA is the only biomarker routinely used in screening for prostate cancer to indicate a prostate biopsy. However, it is not specific for prostate cancer and the neutrophil/lymphocyte ratio has been suggested as an alternative. We present a prospective study of men with an elevated PSA and compare the neutrophil/lymphocyte ratio, free percent PSA, PSA density and the presence of circulating prostate cells to detect clinically significant prostate cancer at first biopsy. Patients and Methods: Prospective study of consecutive men with a PSA 4-10 ng/ml referred for initial prostate biopsy, the results were compared with the neutrophil/lymphocyte ratio, free percent PSA and PSA density. Circulating prostate cells (CPCs) were detected using immunocytochemistry. The blood sample was taken immediately before the prostate biopsy. Results: 1,223 men participated, 38% (467) of whom had prostate cancer detected, of these 322 were clinically significant. The area under the curves were for neutrophil/lymphocyte ratio, free percent PSA, PSA density and CPC detection were 0.570, 0.785, 0,620 and 0.844 respectively. Sensitivity/specificity were 0.388/0.685, 0.419/0.897, 0.598/0.624 and 0.966/0.786 respectively. The neutrophil/lymphocyte ratio did not differentiate between benign and malignant disease. Conclusions: The neutrophil/lymphocyte ratio did not discriminate between benign and malignant prostatic disease in patients with a PSA between 4-10ng/ml.
- انتشار مقاله: 14-01-1398
- نویسندگان: Nigel P Murray,Cynthia Fuentealba,Eduardo Reyes,Marco Antonio Lopez,Anibal Salazar,Simona Minzer,Lorena Munoz,Shenda Orrego,Eghon Guzman,Lucas Arzeno
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,biochemical failure,circulating prostate cells,PRIX score
- چکیده:
- چکیده انگلیسی: Introduction: The use of pre- and post-surgery variables has been used to create nomograms in order to identify
patients at high risk of treatment failure. The PRIX nomogram is one such device; we compare the PRIX nomogram
with the presence of secondary circulating prostate cells to predict those men who will undergo treatment failure.
Methods and Patients: Men who underwent radical prostatectomy for prostate cancer entered the study. The PRIX
score was calculated from the total serum PSA pre-surgery, the biopsy Gleason score and clinical stage. Circulating
prostate cells were detected from venous blood one month after surgery, using differential gel centrifugation and standard
immunocytochemistry with anti-PSA. A test was considered positive when 1 CPC/blood sample was detected. Patients
were followed up for five years and biochemical failure was defined as a serum PSA >0.2ng/ml. Kaplan-Meier and
Cox proportional models were used to calculate survival curves. Results: 321 men participated, of whom 131 (40.8%)
underwent biochemical failure within 5 years. A higher PRIX score was associated with increased failure risk, as was
the presence of CPCs. The predictive power of CPCs was significantly higher than the PRIX score. Combining the
two methods, for equal PRIX scores, scores but CPC positive had a worse biochemical failure free survival than men
with high PRIX scores but CPC negative. For men with PRIX scores of ≥4 the use of CPC detection did not aid in the
clinical decision making process. For those with PRIX scores of 0 and 1, CPC detection identified men with a high risk
of treatment failure. Conclusions: The combined PRIX/CPC score improved the predictive values of men at high risk
of biochemical failure. Both are simple systems that could be incorporated in a general hospital. Further multicenter
studies are warranted to confirm these results.- انتشار مقاله: 18-07-1396
- نویسندگان: Nigel P Murray,Socrates Aedo,Cynthia Fuentealba,Eduardo Reyes,Omar Jacob
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,biochemical failure,circulating tumor cells,CD82
- چکیده:
- چکیده انگلیسی: Objective: The biological characteristics of circulating prostate cells (CPCs) are probably more important than their
mere presence. CD82 is a tumor suppressor, we present the outcome of radical prostatectomy (RP) in men with CD82
positive CPCs. Methods and Patients: consecutive men treated with RP were studied, age, total PSA, Gleason, stage, the
presence of extra-capsular extension, positive surgical margens and infiltration of the seminal vesicles and lymph nodes
were registered. Biochemical failure was defined as a PSA >0.2ng/ml. Immediately before the RP, 8ml of venous blood
was taken to detect CPCs. Mononuclear cells were separated using differential gel centrifugation and CPCs identified
using immunocytochemistry with anti-PSA and anti-CD82. The men were divided into three groups; 1) CPC (-), 2)
CPC (+) CD82 (+) and 3) CPC (+) CD82 (-). The groups were compared with respect to clinical-pathological findings
and biochemical free survival using Kaplan Meier and Cox regression models. Results: 285 men, mean age 65.9 years
participated, 61 (21%) were CPC (-); 57 (20%) were CPC (+) CD82 (+) and 167 (59%) were CPC (+) CD82 (-). Group
1 had low grade small volume cancer, in Group 2, low grade but a larger volume than Group 1 and Group 3 high grade
cancer. Kaplan Meier biochemical free survival curves at 36, 60 and 120 months were; Group 1 98%, 96% and 90%;
for Group 2 93%, 93% and 69% and for Group 3 62%, 44% and 16% respectively. Conclusions: Kaplan Meier survival
curves for Group 1 and Group 2 were similar, although Group 2 men had higher PSA values, more advanced staging
but a similar Gleason score. Group 3 men had a worse prognosis. The results support that biological characteristics of
CPCs are more important than their mere presence identifying men with a high risk of biochemical failure.- انتشار مقاله: 11-08-1396
- نویسندگان: Nigel P Murray,Socrates Aedo,Cynthia Fuentealba,Eduardo Reyes
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,minimal residual disease,biochemical failure,circulating prostate cells,micro-metastasis
- چکیده:
- چکیده انگلیسی:
Introduction: Minimal residual disease (MRD) remaining after curative therapy for prostate cancer has the potential for growth and can result in metastasis. Circulating prostate cells (CPCs) and bone marrow micro-metastasis (mM) could represent different types of MRD. We here determined; biochemical failure free survival rates; time to BF after 10 years follow-up; and the presence of CPCs and mM in patients treated with radical prostatectomy (RP) for prostate cancer. Methods and Patients: One month after RP, blood and bone marrow were sampled for assessment of CPCs and mM. Cases were classified as: group A, CPC negative and mM negative; group B, CPC negative and mM positive; Group C, CPC positive and mM negative; and Group D, CPC positive and mM positive. Subjects were followed with serial determination of PSA levels, recording the time at which BF occurred defined as a serum PSA >0.2ng/ml. After ten years of follow-up Kaplan-Meier survival curves were generated and the restricted mean survival time (RMST) for each group calculated. Results: A total of 321 men participated, 140 in group A with survival of 92.7% (86.3 to 96.2), 39 in group B with 55.8% (37.2 to 70.9); 54 in group C with 6.41% (1.19 to 18.21) and 88 in group D with 4.96%(1.64 to 11.13%. The RMST (in years) were: group A, 9.47 (9.24 to 9.69); group B, 9.23 (8.87 to 9.58); group C, 4.62 (4.46 to 4.77); and group D, 3.57 (3.52 and 3.63) (p-valueConclusions: CPC positive men have more aggressive disease, with increased early failure; men who are only positive for mM are at greater risk of late failure. These two forms of MRD represent different clinical entities with respect to biochemical failure and could be used to guide clinical treatment decisions.- انتشار مقاله: 24-07-1396
- نویسندگان: Nigel P Murray,Socrates Aedo,Cynthia Fuentealba,Eduardo Reyes,Anibal Salazar
- مشاهده