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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,Gastritis,Gastric cancer,peptic ulcer disease,Southeast Asia
- چکیده:
- چکیده انگلیسی: Background: Helicobacter pylori (H. pylori) infection is currently considered as an infectious disease irrespective of
symptoms and stage of disease. This study aimed to survey the impact of H. pylori infection and the current management
approaches in Southeast Asian countries. Materials and methods: This is a survey among 26 experts from 9 Southeast
Asian countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand and Vietnam),
who attended a meeting to develop the ASEAN consensus on H. pylori management in November 2015. Results: The
prevalence of H. pylori varied significantly from 20% to 69% among countries, highest in Myanmar and lowest in
Malaysia. The rate of H. pylori infection in patients with gastritis, peptic ulcer disease and gastric cancer (GC) also
varied significantly, not only among countries but also among regions within the same country. The most common
method for H. pylori diagnosis before treatment was rapid urease test, followed by urea breath test. In multi-ethnic
countries, some ethnic groups including Chinese, Batak and Minahasanese were considered as having higher risk of
GC. There have been no national screening programs for GC in all countries, and a majority of patients with GC were
diagnosed in advanced stages with very poor 5-year survival. Conclusions: The prevalence of H. pylori infection and
its infection rates in related gastrointestinal diseases were significantly different among Southeast Asian countries. The
prognosis of patients with GC in the region was very poor. The result of this survey is a platform for future international
and regional research collaboration.- انتشار مقاله: 08-03-1397
- نویسندگان: Duc Trong Quach,Ratha-korn Vilaichone,Khien Van Vu,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,Vietnam,Gastric cancer,Carcinoma,Early-onset
- چکیده:
- چکیده انگلیسی: Aim: To assess the endoscopic and clinicopathological features of early-onset gastric cancer (EOGC) in Vietnamese,
a population with intermediate risk of gastric cancer. Patients and methods: Consecutive patients diagnosed with
gastric adenocarcinoma were prospectively recruited. The demographic, clinical data in each patient were collected.
The location and macroscopic type of all gastric lesions suspected to be malignant were reported according to the
Japanese classification. The histologic tumor type of gastric cancer (GC) was classified according to the Lauren
classification. Helicobacter pylori (H. pylori) infection were diagnosed by rapid urease test and urinary H. pylori
antibody test. The infection was diagnosed when at least one of the two tests was positive. Results: The rate of EOGC
(i.e. ≤ 40 years of age) was 16.3% (23/141). The median age of patients with EOGC was 35 (range 28 – 40) years and
the male-to-female was 1:1.09. Compared to the older group (i.e. ≥ 50 years of age), the rates of positive family history,
H. pylori infection and alarm features in the EOGC group were not significantly different (0.0% vs. 5.4%, p = 0.581;
73.9% vs. 66.3%, p = 0.620; and 60.8% vs. 79.3%, p = 0.100; respectively). The EOGC group had significantly higher
rate of tumor extending to entire stomach (21.7% vs. 3.4%, p = 0.003); but the rate of diffuse-type GC between the two
groups were not significantly different (87.0% vs. 71.7%, p = 0.181). Conclusions: Vietnamese patients with EOGC had
higher rate of tumor extending to entire stomach compared to the older group. But the family history of GC, H. pylori
infection and the pathological characteristics were not significantly different between the two groups. Environmental
factors which play important roles in the development of EOGC in Vietnam should be investigated in future study.- انتشار مقاله: 20-10-1396
- نویسندگان: Duc Trong Quach,Den Van Ha,Toru Hiyama
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibiotic resistant,Helicobacter pylori,ASEAN
- چکیده:
- چکیده انگلیسی: Objective: Antibiotic resistance has significantly impact on eradication rates for H. pylori infection and remains
important cause of treatment failure worldwide including ASEAN countries. The aim of this study was to survey
the prevalence and antibiotic resistant pattern of H. pylori infection in ASEAN. Methods: This study was a survey among
26 experts from 9 ASEAN countries including Thailand, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines,
Singapore and Vietnam whom attended a meeting to develop the ASEAN consensus on H. pylori management in Bangkok
in November 2015. A questionnaire was sent to each member of the consensus meeting. The detail of the questionnaire
included information about prevalence of H. pylori infection, facilities to perform H. pylori culture, molecular testing
for antibiotic resistance and antibiotic resistance rate in their countries. Results: H. pylori infection remain common
in ASEAN ranging from 20% in Malaysia, 21-54% in Thailand and 69% in Myanmar. Most of ASEAN countries
can perform H. pylori cultures and antibiotic susceptibility tests except Laos and Cambodia. In ASEAN countries,
metronidazole resistant H pylori is quite common whereas amoxicillin resistance remain rare. Clarithromycin resistance
results in a significant decrease in H. pylori eradication rate with clarithromycin-containing regimens. The prevalence of
clarithromycin resistance varies in ASEAN countries being high in Vietnam (30%) and Cambodia (43%), moderate to high
in Singapore (17%) and low in Malaysia (6.8%), Philippine (2%) and Myanmar (0%). In Thailand, clarithromycin
resistance tends to higher in large cities (14%) than in rural areas (~3.7%). Conclusion: ASEAN countries should
develop a standard protocol for regular susceptibility testing of H. pylori so that clinicians would be better able to
choose reliably effective empiric therapies. The wide range of antibiotic resistance in ASEAN countries suggests that
the preferred first line regimen should be depend on the local antibiotic resistance other than single recommendation.- انتشار مقاله: 30-11-1396
- نویسندگان: Ratha-Korn Vilaichone,Duc Trong Quach,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده